Cordarone Tablets Uses Dosage Side Effects Price

Cordarone Tablets (100 MG, 200 MG) Uses Dosage Details

Cordarone Tablets 100 MG and 200 MG contains Amiodarone HCL which is a potassium channel blocking agent. Meanwhile it is iodinated benzofuran derivative. It has widely used as antiarrhythmic and anti angianl drug. On the other hand it is very effective against a wide variety of arrhythmias. It has prominent adverse effects and unusual pharmakokinetic properties that have limited its use.

Cordarone Tablets Uses Dosage Administration Side Effects Benefits Formula Ingredients Price Details
Amiodarone HCL 100 MG Tablets

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Formula Ingredients Composition

  • 100 MG Tablets Contains     :     Amiodarone Hydrochloride Ph- Eur 100 MG
  • 200 MG Tablets Contains     :     Amiodarone Hydrochloride Ph- Eur 200 MG

Cordarone Tablets Uses & Indications

Cordarone tab generally used and indicated only for the treatment of severe rhythm disorder, not responding to other therapy or when other treatment cannot be used:

  • Atrial rhythm disorders (conversion of fibrillation or flutter, and maintenance of sinus rhythm following conversion)
  • Nodal rhythm disorders,
  • Ventricular rhythm disorders (life-threatening ventricular premature contractions, ventricular tachycardia salves, prevention of ventricular tachycardia attacks or ventricular fibrillation episodes,
  • Rhythm disorders associated with wolff-parkinson-white syndrome,

In view of its  pharmaceutical   properties, it is indicated in above rhythm disorders. Especially when they are associated with an underlying heart disease (coronary insufficiency, heart failure).

Cordarone Tablets Uses Dosage Administration Side Effects Benefits Formula Ingredients Price Details
Amiodarone HCL 200 MG Tablets

Cordarone Dosage Administration

Initial stabilization: usual Cordarone Dosage is 600 mg daily and may be continued for 8 to 10 days. Maintenance: The minimum effective dose should used, according to individual response. Meanwhile, it may range between Cordarone 100 mg daily to Cordarone 400mg daily. On the other hand, it may be given on alternate day (Cordarone 200mg may be given every day where Cordarone100mg are recommended daily). Therapeutic windows have also recommended (2 days a week). Meanwhile they are possible due to the prolonged therapeutic action of the medicine.

Contraindication Details For Its Use

  • Sinus bradycardia and sino-atrial heart block.
  • Sick sinus syndrome, except used in conjunction with a pacemaker (risk of sinus arrest).
  • High grade conduction disorders, except when used in conjunction with a pacemaker.
  • Thyroid dysfunction
  • Known hypersensitivity to iodine,
  • Combined therapy with drugs which may induce Torsades de pointes.
  • Pregnancy, unless exceptional circumstances
  • Lactation

Special Warning And Precautions

Special Warning:

In the elderly, heart rate may be more markedly decreased. Generally it induces ECG changes, QT prolongation (in relation with prolonged repolarization) with the possible development of U-waves. Meanwhile these changes evidence of its pharmacological action and do not reflect toxicity.

Precautions:

Most importantly, Undesirable effects are related in most cases with drug overloading. Therefore careful attention should paid in determining the minimum effective maintenance in order to avoid or to minimize undesirable effects. On the other hand, patients should instructed to avoid sun exposure or to use protective measures during therapy. Meanwhile, in patients with personal or family history of thyroid disorders, caution should be exercised when administering the medicine if it is necessary, to minimum effective dosage should be used and careful clinical and biological monitoring should be undertaken.

All Drug Interactions Details

  • Combined therapy with drug that may induce torsades de pointes contraindicated.
  • Antiarrhythic agents including bepridil, class1a – quinidine type-agents, sotalol.
  • Non-antiarrhythmic agents vincamine, sultopride, Erythromycin iv, Pentamidine in case of parenteral  administration as there is an increased risk of potentially lethal torsades de pointes.
  • Combined therapy with the following drugs is not recommended:
  • Beta-blockers and certain calcium channel inhibitors (verapamil, diltiazem) as disturbances of automaticity (excessive bradycardia) and conduction may occur.
  • Stimulating laxative agents as their use may cause hypokalemia and therefore increase the risk of Torsades de pointes; another tyoe of laxative agents should be used.

On the other hand, Caution should exercised when using the following drugs in combination with this product

1- Agents which may induce hypokalemia.
  • Diuretics inducing hypokalemia, either alone or combined.
  • Systemic corticosteroids (gluco- mineralo-) tetrasactide
  • Amphotericin B (iv)

It is necessary to prevent occurrence of hypokalemia (and to correct hypokalemia when required); QT interval should be monitored and in case of Torsades de pontes, antiarrhythmic agents should not be given (electrosystolic pacing should be instituted; IV magnesium may be used).

2- Oral anticoagulant agents:

Due to the potentiation of oral anticoagulant therapy and the increased risk of bleeding, more frequent monitoring of prothrombin level and dosage adjustment of oral anticoagulant during treatment with and after discontinuation of amiodarone therapy is necessary.

3- Digitalis:

Disturbances of automaticity (excessive bradycardia) and atrioventricular conduction (synergistic action) may occur. In addition with digoxin there is a possible increases in the plasma digoxin concentration (due to the decrease of diggoxin clearance). Meanwhile clinical, ECG and bilogical monitoring (including digoxin plasma levels if relevant) should be undertaken. On the other hand dosage adjustment of digitalis treatment my necessary.

4- Phenytion:

Possible increase of plasma phenytion levels with signs of over dosage (particularly neurological signs. Meanwhile clinical monitoring should undertaken and phenytion dosage should reduced as soon as over dosage signs appear, phenytoin plasma levels may determined.

5- General Anesthesia, Oxygenotherapy

Potentially severe complication have reported in patients undergoing general anesthesia. Bardycardia unresponsive to atropine, hypotension, disturbances of conduction, decreased cardiac output. Mean while a few cases of severe respiratory complications resulting sometimes in fatalities have observed most often in the period immediately after surgery (adult acute respiratory distress syndrome). On the other hand a possible interaction with a high oxygen concentration may be implicated. However before surgery the anesthetist should informed that the patient is taking amiodarone.

6- Cyclosporine:

Possible increase of cyslosporine plasma levels related to a decrease of the clearance of this drug. Mean while the dose should be adjusted.

Cordarone Capsules Use In Pregnancy And Lactation

In view of its effects on the foetal thyroid gland, amiodarone is contra-indicated during pregnancy, except in exceptional cases. Mean while Amiodarone is excreted in breast milk in significant quantities. Therefore amiodarone contra-indicated in nursing mothers.

Cordarone Tablets Side Effects

Ophthalmological

Corneal micro deposits, almost always present in adults usually limited to the area under the pupil and they do not require treatment discontinuation. They rarely associated with coloured halos in dazzling light or sensation of fog. Corneal micro deposit consists of complex lipidic deposits and  reversible following treatment discontinuation. Otherwise, a few cases of optic neuritis have reported. At present the relationship with amiodarone has not formally established. If blurred or decreased vision occurs, ophthalmo-logical examination recommended.

Dermatological

Photosensitization: patients should instructed to avoid sun exposure (and as a rule UV rays exposure) during therapy. Cases of erythema have also reported during the course of radiotherapy. Skin Rashes: Usually of little specificity including exceptional cases of exfoliative dermatitis have been reported. The relationship with the drug has not established. State grey or bluish pigmentations of the skin may occur in case of prolonged treatment with high daily dosages. Such pigmentations slowly disappear following treatment discontinuation.

Pulmonary:

Cases of pulmonary toxicity (hypersensitivity pneumonitis, alveolar / interstitial pneumonitis or fibrosis, pleuritis, bronchiolitis obliterans organizing pneumonia / Boop),resulting sometimes in fatalities, have  reported. So Chest X-ray should  performed in patients developing dyspnea (at effort) whether in isolation or associated with deterioration of general health status (fatigue, weigh loss, fever). the pulonary disorder generally reversible following early withdrawal of amiodarone therapy. Meanwhile Corticosteriod therapy may also considered. Clinical signs usually resolve within 3 to 4 weeks, followed by slower radiological and lung function improvement (several months). A few cases of adult of acute respiratory after surgery (a possible interaction with a high oxygen concentration may implicated).

Neurological:

Sensitive motor peripheral neuropathy and / or myopathy, usually reversible on withdrawal of drug. Other: Extrapyramidal tremor, cerebeller ataxia, exceptional benign intrecranial hypertension.(pseudo-tumor cerebri) and nightmares.

Hepatic:

Regular monitoring of liver function tests (transaminases)  recommended during treatment. Isolated elevation of serum transaminases, which are usually moderate (1.5 to 3 times normal) have been reported at the beginning of therapy; they are regress with dose reduction or even spontaneous.

  • A few cases of acute liver disorder with elevated serum transaminases and / or jaundice, which included some fatalities have also reported; in such cases treatment should  discontinued .
  • There have also reports of chronic liver disease (possible hepatomegaly, transaminases elevated 1.5 to 5 times normal). Therefore regular monitoring of liver function test recommended during therapy. Clinic and biological abnormalities usually regress upon cessation of treatment; nevertheless, fatal case have reported.

Cardiac

  • Bradycardia which  generally moderate and dose related. In some cases (sinus node dysfunction, elderly patients), marked baradycardia or more exceptionally sinus arrest have reported.
  • There have been rare instances of conduction disturbances (sinoatrial block, AV block of various degrees).
  • Occurance of new arrhythmia or aggravation of the pre-existing trouble. Followed in some cases by cardiac arrest have reported in view of current knowledge. It is not possible to differentiate what may be due the drug and what may be related to the underlying cardiac condition or may be the result of a lack of efficacy of therapy. Meanwhile these effects more rarely reported than with most of the other anti-arrhythmic agents. And they occur in general in case of certain product interactions or electrolytic disorders.

Others

Benign digestive disorders (nausea, vomiting, dysgeusia) which usually occur with loading dosage and which regress with dose reduction.

  • Alopecia
  • A few cases of epididymitis have reported. The relationship with the tablet has not established.
  • There have been rare cases of various clinical features. Which may suggest a hypersensitivity reactions. Vasculitis, renal involvement with elevation of creatinine levels, thrombocytopenia.
  • Few exceptional cases of haemolytic anemia or aplastic anemia have also reported.
Cordarone Tablets Overdosage

Little information is available regarding acute overdosage with amiodarone. Sinus bradycardia of spontaneously resolving attacks of ventiricular tachycardia may occur. Most often the patient does not demonstrate clinical sign. Nevertheless due to the pharmacokinetics of amiodarone, the patient should monitored long enough. Particularly with regard to cardiac status. Neither amiodarone nor its metabolites can dialyzed.

Medications  Storage Instructions

Most importantly keep cordarone Tablets away from the children. On the other hand protect from moisture and direct sun light exposure. Lastly, you must read the medicine packing for the expiry date printed on the pack and if the medicine is expired you must not use it.

 

Cordarone (100 MG, 200 MG) Tablets (Rs.  PKR) And $  USD in USA

Disclaimer

All the information about product uses, dosage side effects, formula, ingredients, indications, contraindications, drug interactions, warnings & precautions as well as it’s safe to use during pregnancy and lactation is purely based on the information available on the internet. And it is only provided here for general education and information purposes only. So do not take action about any of the information you found here because we do not guarantee the authenticity of each and every piece of information available on this website. All the information we produced is purely based on FDA-approved literature and does not substitute professional medical advice. This information is not intended to substitute medical advice, diagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical condition.

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