Lamnet Tablets (Lamotrigine) Medicine Uses Dosage Side Effects Price

Lamnet (Lamotrigine) Tablets Uses Details

Lamnet Tablets is the brand name of Lamotrigine. Lamotrigine is a triazine derivarive and chemically Lamotrigine is identified as 6-(2,3-dichlorophenyl)-1,2, 4-triazine-3, 5-diamine, prepared by chemical synthesis. It is oral antiepileptic and anticonvulsant agent developed based on the observation that some antiepileptic drugs possess antifolate reductase. It has relatively little antifolate activity. This blocks voltage dependent sodium channels.

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Lamnet Tablets Presentations And Composition

• Lamnet tablets 5 mg: Pink, oblong  scored chewable/dispersible, each containing Lamotrigine 5 MG
• 25 MG Lamnet Tablets: White rounded scored tablets, each containing Lamotrigine 25 MG
• Lament Tablets 50 mg: Pink rounded scored tablets, each containing Lamotrigine 50 MG
• Lament Tablet 100 mg: Pink rounded scored tablets, each containing Lamotrigine100 MG

Lamnet Tablets Mechanism Of Action

Lament (Lamotringine) Tablets use-dependent blocker of voltage sodium channels. Meanwhile, It produced a use and voltage-dependent block of sustained repetitive firing in cultured neurons. And inhibits the pathological release of glutamate (the amino acid which plays a key role in the generation of epileptic seizures). As well as inhibiting glutamate evoked bursts of action potentials.

Lamnet (Lamotrigine) Uses & Indications

Most importantly, Lament indicated for use as adjunctive or monotherapy in the treatment of epilepsy for partial seizures and generalized seizures. In addition, Including tonic-clonic seizure and the seizures associated with Lennox-Gastaut Syndrome.

Children (2 to 12 years of age)

Lamnet  Drug indicated as adjunctive therapy in the treatment of epilepsy for partial seizures and generalized seizures. Including tonic-clonic seizures and the seizures associated with Lennox-Gastant syndrome initial monotherapy treatment in newly diagnosed pediatric patients not recommended.

Bipolar Disorder: Adult (18 years of age and over);

It indicated for the prevention of mood episodes in patients with bipolar disorder, predominantly by preventing depressive episodes.

Dosage and Administration

(Lament Tablets) dispersible tablets dispersed in a small volume of water (at least enough to cover the whole tablet) or swallowed whole with a little water. Meanwhile, If a calculated Dose e.g. for use in children (epilepsy only ) or patients with hepatic impairment cannot be divided into multiple lower strength tablets. On the other hand, The dose to be administered is equal to the nearest lower of the whole tablet.

Dosage In Epilepsy Add-On Therapy

However, In patients taking valproate with any other AED the initial Dose is Lamotrigine 25 MG every alternate day for two weeks. Followed by 25 MG once a day for two weeks. Thereafter, the Doses should increase by a maximum of 25 MG to 50 MG every one to two weeks until the optimal response achieved. Lamnet Tablets Dosage in Renal Impairment Firstly, Caution should exercised when administering tab to patients with renal failure. Most importantly, For patients with end-stage of renal failure, initiate dosage based on patients AED regime, reduced maintenance doses may be effective for patients with significant renal functional impairment.

Drug Precautions and Warnings

There have been reports of adverse skin reactions, which have generally occurred within the first 8 weeks after initiation of  treatment. Meanwhile, the majority of rashes are mild and self-limiting. However serious, potentially life-threatening skin rashes including Stevens johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) reported, On the other hand, the risk higher in children than in adults. Available data from a number of studies suggest the incidence in children requiring hospitalization ranges from 1 in 300 to 1 in 100 in children, the initial presentation of a rash can be mistaken for an infection. Additionally, the overall risk of rash appears to be strongly associated with;

• High initial doses and exceeding the recommended dose escalation of Lamotrigine therapy.
• Concomitant use of valproate, which increased the mean half-life of the medication nearly two-fold.

Drug Interactions Details

Enzyme inducing agents such as

• Phenytoin
• Carbamazepine
• Phenobarbitone
• Primidone

Firstly, it enhances the metabolism of the capsule leading to increased clearance and subsequent reduction of the elimination half-life of this capsule. Concomitant use of valproic acid increased the half-life and plasma concentrations of valproic acid may decrease slightly when the tab added. Most importantly, no evidence was shown that Lamotrigine the plasma concentration of concomitant antiepileptic drugs. Meanwhile, the dosage does not displace other antiepileptic drugs from protein binding sites. There is no evidence that these Tablets cause clinical significant induction or inhibition of hepatic oxidative drug-metabolizing enzymes. However, it may induce its own metabolism but the effect is modest and unlikely to have significant clinical consequences. On the other hand, the dosage not seem to affect plasma concentrations of Ethinyl estradiol and levonorgestrel following the administration of the oral contraceptive pill. However, as with the introduction of other chronic therapy in patients taking oral contraceptives, any change in the menstrual bleeding pattern reported to the patients to the patient’s physician.

Effects on Ability to Drive and use Machines

The Effects on fine visual-motor coordination, eye movements, body sway, and subjective sedative effects did not differ from placebo. However, individuals with a character such as dizziness and diplopia have been reported. Consequently, As there is individual variation in response to all antiepileptic drug therapy patients should consult their physician on the specific issues of driving and epilepsy.

Lamotrigine (Lamnet Tablets) In Pregnancy and Lactation

Most importantly, It should only be used during pregnancy if expected benefits outweigh the potential risk.

Lamnet Tablets Side Effects

Skin And Subcutaneous Tissue Disorders

Very common     :     Skin rash During other clinical experience Very common     :     Skin rash Rare                         :     Stevens johnson Very Rare             :     Toxic epidermal necrolysis. Rarely serious potentially life-threatening skin rashes, including stevens-johnson syndrome and toxic epidermal necrolysis (Lyell syndrome ) have been reported. Although the majority recover on drug withdrawal some patients experience irreversible scarring and there have been rare cases of associated death.

• Firstly, High initial doses of this medication and exceeding the recommended dose escalation of Lamotrigine therapy.
• Concomitant use of valproate. Rash has also been reported as part of hypersensitivity syndrome associated with a variable pattern of systemic symptoms.

Blood and Iymphatic system disorders

Very Rare     :     Hematological abnormalities including

• Neutropenia
• Leucopenia
• Anaemia Thrombocytopenia
• Pancytopenia aplastic anemia
• Agranulocytosis

On the other hand, Hematological abnormalities may not be associated with hypersensitivity syndrome.

Immune System Disorders

Very Rare     :      Hypersensitivity syndrome including such symptoms as:

• Fever
• Lymphadenopathy
• Facial Oedema
• Abnormalities of the blood and liver
• Disseminated intravascular coagulation (DIC).

Meanwhile, Rash has also been reported as part of a hypersensitivity syndrome associated with a variable pattern of symptoms including fever. On the other hand,  lymphadenopathy, facial edema, and abnormalities of the blood and liver. However, the syndrome showed a wide spectrum of clinical severity and may rarely lead to disseminated intravascular coagulation (DIC) and multiorgan failure. Therefore, It is important to note that early manifestations of hypersensitivity (eg. fever lymphadenopathy) may present even though rash is not evident. However, If such signs and symptoms present the patients evaluated immediately and lamotrigine discontinued if an alternate etiology cannot be established.

Psychiatric Disorders

Common          :          Irritability. Uncommon     :         Aggression. Very Rare          :           Tics, hallucinations, confusion. Nervous System Disorders During Monotherapy Clinical Trials Very common     :      Headache Common                :       Drowsiness , insomnia, dizziness , tremor . Uncommon           :        Ataxia. During other clinical experience. Very common       :        Headache, dizziness . Common                   :        Nystagmus, trenmor, ataxia, drowsiness, insomnia. Very Rare                  :         Agitation unsteadiness, movement disprders, worsening of parkinson disease, extrapyramidal effects.  choreoathetosis, increase in seizure frequency. Therefore reported that Lamoptrigine may worsen Parkinson’s symptoms in patients with pre-existing Parkinson, s disease. On the other hand,  isolated reported of extrapyramidal effects and choreoathetosis in patients without this underlying condition.

Eye Disorders

Very Common       :      Diplopia blurred vision Rare                            :       Conjunctivitis

Gastrointestinal Disorders

Common                  :         Nausea. During other clinical experience Common                  :          Gastrointestinal disturbance (including vomiting and diarrhea).

Hepato-biliary Disorders

Very Rare                 :           Increased liver function tests, hepatic dysfunction, and hepatic failure. Meanwhile, Hepatic dysfunction usually occurs in association with hypersensitivity reactions. But isolated cases have been reported without overt signs of hypersensitivity.

Musculoskeletal And Connective Tissue Disorders

Very Rare                :            Lupus like reactions. General   disorders and administration site conditions Common                  :          Tiredness. Biospar Disorder The undesirable Lamotrigine Side effects below should considered alongside those seen in epilepsy for an overall safety profile.

Skin And Subcutaneous Tissue Disorders

During bipolar disorder clinical trials Very common           :               Skin rash Rare                                :               Stevens johnson syndrome.

Nervous System Disorders

During bipolar disorder clinical trials Very Common           :            Headache. Common                       :            Agitation, somnolence, dizziness.

Musculoskeletal and connective tissue disorders

During bipolar disorder clinical trials Common                        :          Arthralgia General disorders and administration site conditions During bipolar disorders clinical trials Like. Common                        :         Pain, back pain

Lamnet (Lamotrigine) Tablets Overdose Symptoms And Effects

Symptoms And Signs Firstly the Ingestion of Lamotrigine between 1.35 and 4 g has been reported in a few patients. However, Clinical consequences were not severe, signs and symptoms include

• Nystagmus
• Ataxia
• Dizziness
• Somnolence
• Headache
• Vomiting

Lamotrigine Overdose Treatment

Most importantly, In the event of Lamotrigine Overdose, the patients should admit to the hospital and given appropriate supportive therapy. Meanwhile, Gastric lavage should be performed if indicated.

Lament Tablets Storage Instructions

Most importantly, protect the drug from moisture, freezing, and also protect it from heat and sunlight. On the other hand, always keep your medicines out of the reach of the children.

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Lamnet (Lamotrigine) Price (Rs. 240 PKR)

 

Disclaimer

All the details of the medicine provided on this website Pharmacy Online Here are only for informational purposes and there is no intent to substitute for professional medical advice, diagnostic, and treatment purposes. Therefore, always get medical advice from any qualified healthcare provider doctor, or pharmacist for any questions about your medical conditions, symptoms, or disorder. So do not disregard the medical advice of your professional healthcare provider or delay it simply because of the information your read here on this website.  Note:– Always Use Any Type Of Medicines Only Under The Supervision Of A Professional Healthcare Provider, Doctor, Or Pharmacist.