Lamnet (Lamotrigine) Tablets Uses Details
Lamnet Tablets is the brand name of Lamotrigine. Lamotrigine is a triazine derivarive and chemically Lamotrigine is identified as 6-(2,3-dichlorophenyl)-1,2, 4-triazine-3, 5-diamine, prepared by chemical synthesis. It is oral antiepileptic and anticonvulsant agent developed based on the observation that some antiepileptic drugs possess antifolate reductase. It has relatively little antifolate activity. This blocks voltage dependent sodium channels.More Useful Links: Pregnacare Vitabiotics, Conception, Max, Omega 3, Tablets And Creams
Lamnet Tablets Presentations And Composition
- Lamnet tablets 5 mg: Pink, oblong scored chewable/dispersible, each containing Lamotrigine 5 MG
- 25 MG Lamnet Tablets: White rounded scored tablets, each containing Lamotrigine 25 MG
- Lament Tablets 50 mg: Pink rounded scored tablets, each containing Lamotrigine 50 MG
- Lament Tablet 100 mg: Pink rounded scored tablets, each containing Lamotrigine100 MG
Lamnet Tablets Mechanism Of Action
Lament (Lamotringine) Tablets use-dependent blocker of voltage sodium channels. Meanwhile, It produced a use and voltage-dependent block of sustained repetitive firing in cultured neurons. And inhibits the pathological release of glutamate (the amino acid which plays a key role in the generation of epileptic seizures). As well as inhibiting glutamate evoked bursts of action potentials.Lamnet (Lamotrigine) Uses & Indications
Most importantly, Lament indicated for use as adjunctive or monotherapy in the treatment of epilepsy for partial seizures and generalized seizures. In addition, Including tonic-clonic seizure and the seizures associated with Lennox-Gastaut Syndrome.Children (2 to 12 years of age)
Lamnet Drug indicated as adjunctive therapy in the treatment of epilepsy for partial seizures and generalized seizures. Including tonic-clonic seizures and the seizures associated with Lennox-Gastant syndrome initial monotherapy treatment in newly diagnosed pediatric patients not recommended.Bipolar Disorder: Adult (18 years of age and over);
It indicated for the prevention of mood episodes in patients with bipolar disorder, predominantly by preventing depressive episodes.Dosage and Administration
(Lament Tablets) dispersible tablets dispersed in a small volume of water (at least enough to cover the whole tablet) or swallowed whole with a little water. Meanwhile, If a calculated Dose e.g. for use in children (epilepsy only ) or patients with hepatic impairment cannot be divided into multiple lower strength tablets. On the other hand, The dose to be administered is equal to the nearest lower of the whole tablet.Dosage In Epilepsy Add-On Therapy
However, In patients taking valproate with any other AED the initial Dose is Lamotrigine 25 MG every alternate day for two weeks. Followed by 25 MG once a day for two weeks. Thereafter, the Doses should increase by a maximum of 25 MG to 50 MG every one to two weeks until the optimal response achieved. Lamnet Tablets Dosage in Renal Impairment Firstly, Caution should exercised when administering tab to patients with renal failure. Most importantly, For patients with end-stage of renal failure, initiate dosage based on patients AED regime, reduced maintenance doses may be effective for patients with significant renal functional impairment.Drug Precautions and Warnings
There have been reports of adverse skin reactions, which have generally occurred within the first 8 weeks after initiation of treatment. Meanwhile, the majority of rashes are mild and self-limiting. However serious, potentially life-threatening skin rashes including Stevens johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) reported, On the other hand, the risk higher in children than in adults. Available data from a number of studies suggest the incidence in children requiring hospitalization ranges from 1 in 300 to 1 in 100 in children, the initial presentation of a rash can be mistaken for an infection. Additionally, the overall risk of rash appears to be strongly associated with;- High initial doses and exceeding the recommended dose escalation of Lamotrigine therapy.
- Concomitant use of valproate, which increased the mean half-life of the medication nearly two-fold.
Drug Interactions Details
Enzyme inducing agents such as- Phenytoin
- Carbamazepine
- Phenobarbitone
- Primidone
Effects on Ability to Drive and use Machines
The Effects on fine visual-motor coordination, eye movements, body sway, and subjective sedative effects did not differ from placebo. However, individuals with a character such as dizziness and diplopia have been reported. Consequently, As there is individual variation in response to all antiepileptic drug therapy patients should consult their physician on the specific issues of driving and epilepsy.Lamotrigine (Lamnet Tablets) In Pregnancy and Lactation
Most importantly, It should only be used during pregnancy if expected benefits outweigh the potential risk.Lamnet Tablets Side Effects
Skin And Subcutaneous Tissue Disorders
Very common : Skin rash During other clinical experience Very common : Skin rash Rare : Stevens johnson Very Rare : Toxic epidermal necrolysis. Rarely serious potentially life-threatening skin rashes, including stevens-johnson syndrome and toxic epidermal necrolysis (Lyell syndrome ) have been reported. Although the majority recover on drug withdrawal some patients experience irreversible scarring and there have been rare cases of associated death.- Firstly, High initial doses of this medication and exceeding the recommended dose escalation of Lamotrigine therapy.
- Concomitant use of valproate. Rash has also been reported as part of hypersensitivity syndrome associated with a variable pattern of systemic symptoms.
Blood and Iymphatic system disorders
Very Rare : Hematological abnormalities including- Neutropenia
- Leucopenia
- Anaemia Thrombocytopenia
- Pancytopenia aplastic anemia
- Agranulocytosis
Immune System Disorders
Very Rare : Hypersensitivity syndrome including such symptoms as:- Fever
- Lymphadenopathy
- Facial Oedema
- Abnormalities of the blood and liver
- Disseminated intravascular coagulation (DIC).
Psychiatric Disorders
Common : Irritability. Uncommon : Aggression. Very Rare : Tics, hallucinations, confusion. Nervous System Disorders During Monotherapy Clinical Trials Very common : Headache Common : Drowsiness , insomnia, dizziness , tremor . Uncommon : Ataxia. During other clinical experience. Very common : Headache, dizziness . Common : Nystagmus, trenmor, ataxia, drowsiness, insomnia. Very Rare : Agitation unsteadiness, movement disprders, worsening of parkinson disease, extrapyramidal effects. choreoathetosis, increase in seizure frequency. Therefore reported that Lamoptrigine may worsen Parkinson’s symptoms in patients with pre-existing Parkinson, s disease. On the other hand, isolated reported of extrapyramidal effects and choreoathetosis in patients without this underlying condition.Eye Disorders
Very Common : Diplopia blurred vision Rare : ConjunctivitisGastrointestinal Disorders
Common : Nausea. During other clinical experience Common : Gastrointestinal disturbance (including vomiting and diarrhea).Hepato-biliary Disorders
Very Rare : Increased liver function tests, hepatic dysfunction, and hepatic failure. Meanwhile, Hepatic dysfunction usually occurs in association with hypersensitivity reactions. But isolated cases have been reported without overt signs of hypersensitivity.Musculoskeletal And Connective Tissue Disorders
Very Rare : Lupus like reactions. General disorders and administration site conditions Common : Tiredness. Biospar Disorder The undesirable Lamotrigine Side effects below should considered alongside those seen in epilepsy for an overall safety profile.Skin And Subcutaneous Tissue Disorders
During bipolar disorder clinical trials Very common : Skin rash Rare : Stevens johnson syndrome.Nervous System Disorders
During bipolar disorder clinical trials Very Common : Headache. Common : Agitation, somnolence, dizziness.Musculoskeletal and connective tissue disorders
During bipolar disorder clinical trials Common : Arthralgia General disorders and administration site conditions During bipolar disorders clinical trials Like. Common : Pain, back painLamnet (Lamotrigine) Tablets Overdose Symptoms And Effects
Symptoms And Signs Firstly the Ingestion of Lamotrigine between 1.35 and 4 g has been reported in a few patients. However, Clinical consequences were not severe, signs and symptoms include- Nystagmus
- Ataxia
- Dizziness
- Somnolence
- Headache
- Vomiting
Lamotrigine Overdose Treatment
Most importantly, In the event of Lamotrigine Overdose, the patients should admit to the hospital and given appropriate supportive therapy. Meanwhile, Gastric lavage should be performed if indicated.Lament Tablets Storage Instructions
Most importantly, protect the drug from moisture, freezing, and also protect it from heat and sunlight. On the other hand, always keep your medicines out of the reach of the children.More Medications Information: Venofer Infusion For Iron Deficiency Anemia Uses Dosage side Effects Price
Lamnet (Lamotrigine) Price (Rs. 240 PKR)
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