Losec Tablets 10MG 20MG 40MG Uses Dosage Side Effects Price

What Are Losec Tablets 10MG 20MG 40MG Uses Dosage Side Effects? Brief Details

Losec Tablets 10mg, 20mg, and 40 mg mainly contain the most famous medicine named Omepra-zole. Omepra-zole is an oral antiulcer agent. It is characterized as a gastric acid pump inhibitor because it blocks the final step of gastric acid production. Meanwhile, it has a long duration of action and is very potent, allowing for once-daily administration. Moreover Barrat Pharma Pvt Ltd are the main manufacturer and marketers of this medicine world wide.

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Formula Ingredients Composition

Each of the tabs contains Omepra-zole 10mg, Omepra-zol 20mg, and Omepra-zole 40mg.

What Are Losec Tablets 10mg 20mg 40mg Uses & Indications?

Losec Tablets are mainly indicated and used for the treatment of symptoms Like

• Duodenal Ulcer
• Gastric Ulcer
• NSAID-associated gastric and duodenal ulcers or erosions
• Helicobacter pylori eradication in peptic ulcer disease
• Reflux oesophagitis
• Symptomatic gastro-oesophageal reflux disease
• Zollinger  Ellison syndrome

What Is Tab Losec Tablet Dosage And Method To Use?

Losec capsules are recommended to use in the morning and swallowed whole with half a glass of water. On the other hand, The capsules should not be chewed or crushed. However, follow your pharmacist or doctor’s instruction to take the medicine.

• Dosage For Patients With Swallowing Difficulties

However, it can be opened and the contents swallowed directly with half a glass of water or after mixing the contents in a slightly acidic fluid e. g . fruit juice or applesauce, or in noncarbonated water. The dispersion should be taken immediately (or within 30 minutes ) always stirring just before drinking. Meanwhile, Rinse it down with half a glass of water. On the other hand, such patients can also suck the tab and swallow the pellets with half a glass of water. However, Ingest without chewing the enteric-coated pellets.

• The Dosage Duodenal Ulcer

Meanwhile, The recommended dosage in patients with an active duodenal ulcer is Losec 20 mg once daily. Therefore, Symptom resolution is rapid and in most patients, healing occurs within 2 weeks. On the other hand, For those patients who may not fully heal after the initial course, healing usually occurs during a further 2-week treatment period. However, In patients with poorly responsive duodenal ulcer loss 40 mg once daily is recommended. And after the treatment, the healing normally gets within 4 weeks. Meanwhile, For the prevention of relapse in patients with duodenal ulcer disease the recommended dose is Losec 10 mg once daily. However, If needed the dose can be increased to 20-40 mg once daily for NSAID-associated duodenal ulcer.

• Dosage Gastric Ulcer

Meanwhile, the recommended 20 MG once daily. However, symptom resolution is rapid, and in most patients, healing occurs within 4 weeks. However, for those patients who may not be fully healed after the initial course healing usually occurs during a further 4 weeks treatment period. Meanwhile, In patients with poorly responsive gastric ulcers, 40 mg once daily is recommended. And healing is usually achieved within 8 weeks.  However For prevention of relapse in patients with poorly responsive gastric ulcers, the recommended dose is 20 mg once daily if needed. The dose van increased to 40 mg once daily.

NSAID Associated Gastric Ulcers Duodenal Ulcers Or Gastroduodenal Erosions In Patients With Or  Without Continued NSAID Treatment

Meanwhile, The recommended dosage is 20 mg once daily. However, Symptom resolution is rapid and in most patients, healing occurs within 4 weeks. Therefore, for those patients who may not be fully healed after the initial course healing usually occurs during a further 4 weeks treatment period. On the other hand, for the prevention of NSAID-associated gastric ulcers duodenal ulcers gastroduodenal erosions. And dyspeptic symptoms the recommended dosage is 20 mg once daily.

• Helicobacter Pylori (Hp) Eradication Regimens In Peptic Ulcer Disease

Triple Therapy Regimens:

20 mg amoxicillin 1 g and clari thro mycin 500 mg. All twice a day for one week. Or 20 mg of metro nida zole 400 mg (or tinidazole 500 ) and clari thro mycin 250 mg all twice a day for once a week. Or  40 mg once daily with amoxicillin 500 mg and metro nida zole 400 mg both three times a day for one week.
Dual Therapy Regimens:
40- 80 mg daily with amoxi llin  1. 5 g daily in divided doses for two weeks. In clinical studies, daily doses of 1.5-3 g of amoxicillin have been used. Or  40 mg once daily and clarit from ycin 500 mg three times a day for two weeks.

To ensure healing in patients with active peptic ulcer disease see further dosage recommendations for duodenal and gastric ulcer. In each regimen, if the patient is still hp positive therapy may be repeated.

• Dosage For Reflux Oesophagitis

Meanwhile, The recommended dosage is 20 mg once daily. Normally the speed of treatment of symptoms is very quick and in most patients, healing just occurs only within 4 weeks. For those patients who may not fully healed after the initial course healing usually occurs during a further 4 weeks of treatment period. In patients with severe reflux oesophagitis, 40 mg once daily is recommended. And healing is usually achieved within 8 weeks. For the long-term management of patients with healed reflux oesophagitis the recommended dose 10 mg once daily. If needed the dose can be increased once daily.

• Dose For Symptomatic Gastro-Oesophageal Reflux Disease

On the other hand, the recommended dosage is 20 mg daily. However, Symptom relief is rapid. Patients may respond adequately to 10 mg daily. And therefore individual dose adjustment should be considered. However, If symptom control has not been achieved after 4 weeks of treatment with 20 mg daily. Most importantly, further investigation is recommended.

• Dosage For Zollinger – Ellison Syndrome

Most importantly, In patients with zollinger-Ellison syndrome, the dosage should be individually adjusted. And treatment continued as long as clinically indicated. Meanwhile, The recommended initial dosage is  60 mg daily. On the other hand, All patients with severe disease and inadequate response to other therapies have been effectively controlled. And more than 90% of the patients maintained. And doses of 20-120 mg daily when doses exceed 80 mg daily the dose should be divided and given twice daily.

•  Uses For Impaired Renal Function

The Losec Capsules Dose adjustment is not needed in patients with impaired renal function

•  Dosage In Impaired Hepatic Function

In patients with impaired hepatic function, a daily dose of 10-20 mg may be sufficient.

•  Dosage For Adults(>65 years old)

Generally Dosage adjustment mainly not needed in the treatment for adults.

• Dosage For Child

10 mg 20 mg and 40 mg capsules not approved for use in children.

What Are The Contraindications For The Use Of This Medicine?

Most importantly, Losec Medicine is contraindicated in patients who are Hpersensitivily to ome pra zole substituted benzi mda zoles or to any of the excipients. Meanwhile, Omep ra zole like other proton pump inhibitors (PPIs) must not use concomitantly with nelfinavir.

Is It Safe To Use (Losec) During Pregnancy And Lactation?

Pregnancy well-conducted epidemiological studies indicate no adverse effects of omep ra zole on pregnancy. On the other hand, on the health of the fetus and newborn child. Meanwhile, the drug can use during pregnancy. However, it may be excreted in breast milk influence if any on the child is unknown.

• Effects On Ability To Drive And Use Machines

Meanwhile, Tab Losec is not likely to affect the ability to drive or use machines.

What Are Losec Tablets Side Effects?

However, the medicine is well tolerated but the most common Losec Tablet side effects 1-10 of patients are:

• Headache
• Abdominal pain
• Constipation
• Diarrhea
• Flatulence and
• Nausea
• Vomiting

Most importantly, The following adverse reactions have been identified or suspected in the clinical trials program for Omep ra zole and post-marketing. However, None were found to have dose-related adverse reactions listed below classified according to frequency and system organ class Soc. Most importantly, If you observe any of the side effects after using the medicine you must immediately contact your doctor or pharmacist.

Losec Tablets Capsules Side Effects

 

• Blood And Lymphatic System Disorders

Rare:                    Leukopenia, Thrombocytopenia

Very Rare:        Agranulocytosis, Pancytopenia

• Immune System Disorders

Rare:                  Hypersensitivity Reactions Like Fever, Angioedema, Anaphylactic Reaction or Shock

• Metabolism And Nutrition Disorders

Rare:                  Hyponatraemia

Very Rare:      Hypomagnesaemia

• Psychiatric Disorders

Uncommon:   Insomnia

Rare:                   Agitation, Confusion, Depression

• Nervous System Disorders

Common:          Headache

Uncommon:    Dizziness, Paraesthesia, Somnolence

Rare:                    Taste Disturbance

• Eye Disorders

Rare:                      Blurred Vision

• Ear & Labyrinth Disorders

Uncommon:       Bronchospasm

• Respiratory, Thoracic & Mediastinal Disorders

Rare:                        Bronchospasm

• Gastrointestinal Disorders

Common:               Abdominal Pain, Constipation, Diarrhoea, Flatulence, Nausea, Vomiting

Rare:                         Dry Mouth, Stomatitis, Gastrointestinal Candidiasis

• Hepatobiliary Disorders

Uncommon:           Increased Liver Enzymes

Rare:                           Hepatitis With or Without Jaundice.

Very Rare:                Hepatic Failure, Encephalopathy in Patients with pre-existing liver disease.

• Skin And Subcutaneous Tissue Disorders

Uncommon:             Dermatitis, Pruritus, Rash, Urticaria

Rare:                             Alopecia, Photosensitivity

Very Rare:                  Erythema Multiforme, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis

• Musculoskeletal And Connective Tissue Disorders

Rare:                             Arthralgia, Myalgia

Very Rare:                  Muscular Weakness

• Renal And Urinary Disorders

Rare:                              Interstitial Nephritis

• Reproductive System And Breast Disorders

Very Rare:                   Gynaecomastia

• General Disorders And Administration Site Conditions

Uncommon:                 Malaise, Peripheral Oedema

Rare:                                 Increased Sweating

What Are The Losec Overdose Symptoms & Treatment?

Limited information is available about the Losec Omep ra zole tablet’s overdose side effects and symptoms in humans. Furthermore, it reported that doses of up to 560 mg have been described. And occasional reports were received when single oral doses reached up to 2,400 mg drug. Nausea vomiting dizziness abdominal pain diarrhea and headache have been reported. On the other hand, apathy, depression, and confusion side effects have also reported the overdosage symptoms in single cases.

The symptoms described have transient and no serious outcome has been reported. The rate of elimination unchanged first order kinetics with increased doses treatment if needed is symptomatic.

Storage Instructions

Most importantly keep all the tablets, injections, and syrups out of the reach of the children. On the other hand, Do not store Losec Tablets (Omep ra zole Capsules) over 30 C temperature. Meanwhile, protect medical products from direct sunlight and heat.

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Losec 10MG, 20MG, 40MG Tablets Price

• Price In Pakistan: Rs. 733 PKR
• Price In India: 599 INR
• Price In USA: $ 6 USD

References: 

• https://www.medicines.org.uk/emc/product/1509/smpc
• https://dawaai.pk/medicine/Loseccap-Capsule20-138.html
• https://xediton.com/product/losec-20mg-bottle-100tabs/
• https://www.drugs.com/cdi/losec.html
• https://www.dvago.pk/p/losec-capsules-20-mg-14s