Tamsolin 0.4 MG Tablets Capsules (Tamsulosin HCL) Medicine Uses Dosage Side Effects Price

Tamsolin 0.4 MG Tablets Capsules Uses Dosage Details

Tamsolin Capsules contains Tamsulosin HCL which is a useful antagonist medicine of alpha 1A adrenoceptors in the prostate. Here are all the details about the Tamsuloin Capsules.
Tamsolin 0.4 MG Tablets Capsules (Tamsulosin HCL) Medicine Uses Dosage Administration Side Effects Benefits Formula Ingredients Price Details
Tamsulosina 0.4mg Capsules
 

Formula Ingredients Composition

Tamoslin (Tamsulosin HCL) capsules available for oral administration as:
  • Tamsolin (Tamsulosin) 0.4 mg Capsules
  • Each Capsule contains > 0.4 mg Tamsulosin Hydrochloride

All Pharmacology Details

Mechanism of Action:
Tamsulosin bind selectively and competitively to postysnaptic x1-adrenoceptors. In particular to subtypes alpha/1A and alpha/1D. It brings the relaxation of prostatic and urethral smooth muscle resulting in an increase in urinary flow rate. And it bring a reduction in symptoms of benign prostatic hyperplasia (BPH). It also improves the irritative symptoms in which bladder instability plays an important role
Pharmacokinetics:
Absorption Tamsulosin HCL absorption is essentially complete (>90%) following oral administration under fasting conditions. The time to maximum concentration (T max) reached by four to five hours under fasting conditions. And by six to seven hours when tamsulosin HCL capsules administered with food. Taking this medicine under fasted conditions results in a 30% increase in bioavailability (AUC). And 40 % to 70 % increase in peak concentrations (C max) compared to fed conditions. Distribution However, the product extensively bound to human plasma proteins 94% to 99%. Primarily alpha-1 acid glycoprotein (AAG) with linear binding over a wide concentration range. A minimum distribution to the brain spinal cord and testes. Metabolism However, it shows low pass effect, being metabolized slowly. It extensively metabolized by cytochrome P-450 enzymes in the liver. Most importantly, present in the plasma in the form of unchanged medicine. Excretion Tamsulosin HCL Capsules and its metabolites mainly excreted in the urine with less than 10 % of a dose being present in the form of unchanged medicine. Meanwhile, After a single dose of the medication in the fed state. And in the steady state in patients, elimination half-lives of about 10 and 13 hours.
Special Populations:
Geriatrics However, Intrinsic clearance independent of the tablets binding to AAG. But diminishes with age result in 40% overall higher exposure in Elderly Age between 55 to 75. Compared to the subjects of age in 20 to 32 years.
Tamsolin 0.4MG Capsules (Tamsulosin Hydrochloride) Tablets Uses & Indications
What is Tamsolin Capsules, Tamsulosin HCl Used for or indicated for? So it used to the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). Here are the conditions in which recommended the use of this medicine.
Tamsolin 0.4 Tablets Capsules Dosage And Administration
Tamsolin, Tamsulosin HCL Capsules 0.4 mg once daily recommended as the dose for the treatment of the signs and symptoms of BPH. Meanwhile, The dosage should administered approximately one half hour following the same meal each day. The dose for those patients who use the tab for four weeks but still not respond. Meanwhile, The dose for those can increased to 0.8 mg once daily. Therefore If the administration discontinued. Or interrupted for several days at either the 0.4 mg or 0.8 mg dosage. Therefore, Therapy should started again with the 0.4 mg once daily dose.
Tamsolin (Tamsulosin) Side Effects in Elderly And Other Patients
The following Tamsolina Capsules tablets Side Effects reported in elderly age and other patients during the use of the capsules.
Whole Body Side Effects
  • Headache
  • Infection
  • Asthenia
  • Back Pain
  • Chest Pain
Nervous System Side Effects
  • Dizziness
  • Somnolence
  • Insomnia
  • Decreased Libido
Respiratory System Side Effects
  • Rhinitis
  • Pharyngitis
  • Increased Cough
  • Sinusitis
Digestive System Disorders
  • Dierrhea
  • Nausea
  • Tooth Disorder
Urinogenital System Side Effects
Abnormal Ejaculation

Medicine Contraindications Information

Most importantly, The contraindication details are here for the patients.
  • With known hypersensitivity to this medication or to any excipient of the product
  • With a history of orthostatic hypotension
  • Taking other alpha-adrenergic blocking agents
  • With severe hepatic insufficiency

Warnings & Precautions

  • As with other alpha 1-blockers reduction in blood pressure can occur in individual cases during treatment with its use. As a result of which very rarely syncope can occur. At the first signs of orthostatic hypotension (dizziness, weakness). The patient should sit or lay down until the symptoms disappeared.
  • Before the therapy initiated the patient should examined. To exclude the presence of other conditions which can cause the same symptoms as benign prostatic hyperplasia. Digital rectal examination and when necessary determination of prostate specific antigen should perform before treatment. And at regular intervals afterwards too.
  • The patients at end stage of renal disease (creatinine clearance <10mL/min/1.73m.2). Such patients should approached with caution as these patients have not studied.
  • Patient should advised about the possibility of priapism as a result of the treatment. And other similar medications. Patients should informed that this reaction is extremely rare. But if not brought to immediate medical attention can lead to permanent dysfunction.
  • Intra operative Floppy Iris Syndrome (IFIS) has observed during cataract surgery in some patients taking. Or who have previously treated with alpha 1 adrenoceptor antagonists.

 Drug Interactions Details

  • The pharmacokinetic interaction between cimetidine and it investigated. The results indicate significant changes in its clearance (26% decrease) and AUC (44%) increase. Therefore, tablets should use with caution in combination with cimetidine. Particularly at doses higher than Tamulosin Capsules 0.4 mg Dose.
  • Caution should exercised with concomitant administration of warfarin and tamsulosin HCL.
  • It should used with caution in combination with moderate or strong inhibitors of CYP2D like Fluoxetine. And CYP3A4 like Ketoconazole, particularly at doses higher than Tamulosin 0.4 mg.
Over Dose Symptoms & Treatment Guide
Acute Tamsulosin HCL 0.5 MG overdose has been reported. Meanwhile, The acute hypotension (systolic blood pressure 70mmHg), vomiting and diarrhea observed. Which treated with fluid replacement and the patient could discharged the same day. On the other hand, If acute hypotension occurs after the over dose the cardiovascular support should given and maintained. Therefore, Blood pressure can restored and heart rate brought back to normal by lying the patient down. Meanwhile, If this insufficient then volume expanders and when necessary vasopressors could administered. on the other hand, Renal function should monitored and general supportive measures applied. Dialysis is unlikely to be of help as it is very highly bound to plasma proteins. Most importantly, the measures to impede absorption like emesis can taken. Meanwhile, When large quantities of the medicine involved, gastric lavage can applied. And activated charcoal and an osmotic laxative such as sodium sulphate can be administered. However, in case of any medications overdosage you must visit the nearby hospital and immediately contact your doctor.
Tab  Cap Storage Instructions
Most importantly, Tamsolin (Tamsulosin HCL) Capsules should store below 30 C. Also protect from sunlight and moisture. On the other hand, The expiration date refers to the product correctly stored at the required conditions. Lastly, you must always read the medications packing to know the expiry date of that medicine. And if the medicine expired you must not use the medicine.  

Tamsolin (Tamsulosin HCL) Capsules Tablets Price (Rs.  PKR) and $ 9 USD in USA

 

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Disclaimer

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