Avelox Tablets Uses Dosage Side Effects

Avelox Tablets and Injections contains Moxifloxacin. It is an antibiotic which belongs to third group of fluoroquinolones. Fluoroquinolones are potent bactericidal agents against E.Coli and various other spSalmonella, shigella, enterobacter, campylobacter and neisseeria. However, It has excellent activity against S.pneumoniae. Moxifloxacin used in respiratory tract infections in urinary tract infections and in bones and soft tissue infections.

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Avelox 400MG Uses And Indications

Firstly, Avelox 400 mg tablets used for:

Community Acquired Pneumonia

Firstly, Avelox 400 mg Tablets use indicated in adult patients for community acquired pneumonia caused by susceptible isolates of streptococcus pneumonia (including multi drug resistant streptococcus pneumonia (MDRSP).

• Haemophilus Influenzae
• Moraxella Catarrhalis
• Methicillin Susceptible
• Staphylococcus Aureus
• Klebsiella Pneumoniae
• Mycoplasma Penumoniae
• Chlamydophila Penumoinae

Meanwhile, MDRSP isolates are isolates resistant to two or more of the following antibacterial products:

• Penicillin
• 2nd Generation Cephalosporins
• Cefuroxime
• Macrolides
• Tetracyclines
• Trimethoprim
• Sulfamethoxazole

Uncomplicated Skin And Skin Structure Infections

In Addition, Avelox 400 mg tablets used for adult patients the treatment of uncomplicated skin and skin structure infections caused by susceptible isolated of methicillin susceptible staphylococcus aureus or Streptococcus pyogenes.

Complicated Skin And Structure Infections

Meanwhile, Avelox 400 mg tablets use in adult patients for the treatment of complicated skin and skin structure infection caused by susceptible isolates of methicillin susceptible staphylococcus aureus

• Escherichia Coli
• Klebsiella Pneumoniae
• Enterbacter Cloacae

Complicated Intra Abdominal Infection

Consequently, Avelox 400 mg also indicated in adult patients for the treatment of complicated intra-abdominal infections including polymicrobial infections such as:

• Abscess caused by susceptible isolates of xscherichia coli
• Bacteroides Fragilis
• Streptococcus Anginosus
• Streptococcus Constellatus
• Enterococcus Faecalis
• Proteus
• Mirabilis
• Clostridium Perfringens
• Bacteroides Thetaiataomicron
• Peptosterptococcus Species

Avelox Use For Plague

Meanwhile, Avelox 400mg tablets indicated in adult for the treatment of plague. Including pneumonic and septicemic plague , due to susceptible isolated of yersinia pestis and prophylaxis of plague in adult patients. However, Effects studies of moxifloxacin could not conducted in humans with plague for feasibility reasons. Therefore this indications is based on an efficacy study conducted animals only.

Acute Bacterial Sinusitis

In addition, Avelox Tablets Injection 400 mg/ml indicated in adult patients (18 years of age and older ) for the treatment of acute bacterial sinusitis abs cause by susceptible isolated of streptococcus pneumoniae , haemophilus influenzae , or moraxella catarrhalis. Because fluoroquinolones , including avelox , have been associated with serious reactions. However, For some patients ABS self limiting reserve Avelox for treatment of ABS in patients who have no alternative treatment options.

Acute Bacteria Exacerbation Of Chronic Bronchitis

On the other hand, Avelox 400mg indicated in adult for the treatment of acute bacterial exacerbation of chronic bronchitis (ABECB) cause by:

• Susceptible isolates of Streptococcus Pneumoniae
• Haemophilus Influezae
• Haemophilus Parainfluenzae
• Klesiella Pneumoniae
• Methicilln Susceptible
• Staphylococcus Aureus
• Moraxella Catarrhalis

Because fluoroquinolones , including Avelox , have associated with serious adverse reactions. And for some patients (ABECB) is self limiting, reserve Avelox for treatment of ABECB in patients who have no alternative treatment options .

Avelox Tablets 400 MG Usage

However, To reduce the development of Avelox resistant bacteria and maintain the effectiveness of Avelox and other antibacterial products. Therefore, Avelox should used for only to treat or prevent infections that proven or strongly suspected to be cause by susceptible bacteria. However, when culture and susceptibility are available. Meanwhile, they should considered in selecting or modifying antibacterial. Therefore, in the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Avelox Dosage And Administration

Dosage In Adult Patients

Generally, Avelox Dosage is 400 mg (orally or as an intravenous infusion ) once every 24 hours. Meanwhile, The duration of therapy depends on the type of the infection as described below:

Types Of Infections Dosage/24 Hour Duration/Day

• Community Acquired Pneumonia 400 mg 7 - 14
• Uncomplicated Skin and Skin Structure Infections 400 mg 7
• Complicated SSSI 400 mg 7 - 21
• Complicated Intra Abdominal Infections 400 mg 5 - 14
• Plague 400 mg 10 - 14
• Acute Bacterial Sinusitis 400 mg 10
• Acute Bacterial Exacerbation of Chronic Bronchitis 400 mg 5

Conversion Of Intravenous To Oral Dosing In Adult

Intravenous formulation is indicated when it offers a of administration advantageous to the patients. Therefore, when switching from intravenous to oral formulation, no dosage adjustment necessary. Furthermore, the patient whose therapy is started with Avelox injection may switched to Avelox 400mg tablets when clinically indicated at the discretion of the physician.

Important Administration Instructions

Avelox Tablets

With Multivalent Cations

Administer Avelox 400 mg tablets at least 4 hours before or 8 hours after products containing magnesium, aluminum, iron or zinc, including antacids, sucralfate, multivitamins and didanosine buffered tablets for oral suspension or the pediatric for powder for oral solution.

With Food

Meanwhile, Avelox tablets can be taken with or without food , drink fluids liberally.

Avelox Injection

Most importantly, administer intravenous infusion only. It is not intended for

• Intra arterial
• Intramuscular
• Intrathecal
• Intraperitoneal
• Subcutaneous administration.

Meanwhile, Administer by intravenous infusion a period of 60 minutes by direct infusion or through a Y-type intravenous infusion set which may already be in place. On the other hand, Avoid rapid or bolus intravenous infusion. Therefore, Parenteral products should inspected visually for particulate matter. And discoloration prior to administration, whenever solution and container permit. However, Discard any unused portion because the premix containers are for single use only.

Drug and Diluent Compatibilities

Because only limited data are available on the compatibility of Avelox intravenous injection with other intravenous substance additives. Therefore, other medicine should not added to Avelox injection or infused simultaneously though the same intravenous line. However, If the same intravenous line or a Y-type line used for sequential infusion of other drug. Meanwhile, if the “piggyback” method of administration used the line should flushed before and after the infusion of Avelox injection. However, With an infusion solution compatible with Avelox injection as well as other products administered via this common line.

Compatible Intravenous Solutions.

Most importantly, Avelox injection is compatible with the following intravenous solutions at ratios from 1:10 to 10.1

• 0.9% sodium chloride injection USP
• Molar sodium chloride injection
• 5% dextrose injection
• Streile water for injection USP
• 10/ dextrose for injection USP
• Lactated ringer’s for injection

Avelox Dosage And Strengths

 

Avelox Tablets:

Dull red coated tablet with an oblong convex shape with facet , a dimension of 17×7 mm, M-400 on the side .

Avelox injection

250 ml glass bottle with clear, yellow solution filled with minimum 250 ml.

Avelox Contraindications

Furthermore, Avelox is contraindicated in persons with a history of hypersensitivity to moxifloxacin. In addition it also contraindicate for patients with any of the quinolone class of antibacterials.

Avelox Side Effects

However, the following Avelox serious and otherwise important side effects are discussed in greater detail.

• Disabling and potentially irreversible serious adverse reactions including and tendinitis tendon rupture , peripheral neuropathy and central nervous system effects.
• Tendinitis and tendon rupture
• Peripheral neuropathy
• Central nervous system effects
• Exacerbtion of myasthenia gravis
• QT prolongation
• Other serious and sometimes fatal adverse reactions
• Hypersensitivity reactions
• Clostridium difficile, associated diarrhea
• blood Glucose disturbances
• Photosensitivity, phototoxicity
• Development of drug resistant bacteria

Avelox Tablets Injection Storage Guide

Most importantly, Do not store Avelox 400 mg Tablets over 25C also store it in the original pack to fully protect the Tablets. While keep Avelox injection over 15 C temperature. Most importantly keep all the medical products out of the reach of the children. Therefore it is recommended not to store the Avelox Infusion solution in the refrigerator. On the other hand, always read the packing for the expiry date and do not use any product after the expiry date.

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Avelox 400 MG Tablets Injection