Ceporex Syrup Tablets Capsules Suspension Uses Dosage Details
Ceporex Tablets, Capsules, Syrup Suspension and Injection contains Cephalexin (Monohydrate) a very useful drug. Meanwhile, Cephalexin is a first generation cephalosporin antibiotic Cephalosporins are derivatives of 7-aminocephalosporic acid. On the other hand it related to penicillin in structure. Furthermore, Cephalexin is active against gram positive cocci and used in large variety of bacterial infections Like
- Respiratory Tract Infections
- Skin Infections
- Urinary Tract Infections
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What Is Cephalexin And What It Used For?
Cephalexin is also known with the name of Cefalexin which belongs to the antibiotic drug class of Cephalosporins which generally shows the mechanism of action and side effects like the penicillin. It considered as one of the best and powerful antibiotic which used for the treatment of wide variety of bacterial infections. Moreover, it effectively kills the gram positive and gram negative bacteria in short time to get rid of the symptoms in a quick time. In most parts of the world cephalexin/cefalexin sold under the brand names of Keflex 500mg Tablets and Ceporex Syrup. Most importantly doctors found Cephalexin medication during research in year 1969. But it first approved to use in medicines in the year 1970 in USA and UK.
Ceporex Cephalexin Syrup Tablets Capsules Suspension Injections Uses & Indications
Ceporex (Cephalexin) syrup capsule tablets generally knows as the most effective bactericidal antibiotic medicine. Which is active against a wide range of gram-positive and Gram-negative organisms. Therefore, Ceporex Used for treatment of the following conditions when caused by susceptible bacteria.
- Respiratory tract infections.
- Ear, nose and throat infections.
- Urinary tract infections.
- Gynaecological and obstetric infections.
- Skin, soft tissue and bone infections.
- Dental procedures and treatment of dental infections.
- Bone and Joint Infections
- Otitis media
Ceprox Tablets Syrup Capsules Dosage Administration
Ceporex For Oral Use
Dosage For Adults
The dosage is 1-4 g daily in divided doses. Most infections will respond to 500 mg every 8 yours. For skin and soft tissue infections, streptococcal pharyngitis and mild uncomplicated ut is, the usual dosage is 250 mg every 6 hours or 500 mg every 12 hours. For more severe infections or those caused by less susceptible organisms, larger doses may be needed.
Ciporex Syrup Tablets Dosage For Children
The usual recommended daily ciporex syrup tablet dosage for child is 25-50 mg/kg in divided doses. For skin and soft tissue infections, streptococcal pharyngitis and mild, uncomplicated urinary tract infections, the total daily dose may be divided and administered every 12 hours. For most infections the following schedule is suggested:
Dosage For Infants: (25-60 mg/kg/day)
- Children under 5 years : 125 mg every 8 hours
- Children 5 years and over:250 mg every 8 hours
In severe infections the dosage may be doubled. Meanwhile, In the therapy of otitis media, clinical studies have shown that a dosage of 75-100 mg/day in 4 divided doses is required. In the treatment of beta-hamemolytic streptcococcal infection, a therapeutic doses should be administered for at least 10 days.
Dosage For Elderly
The dosage is as for adults. The ceporex dosage should be reduced if renal function is markedly impaired.
Renal Impairment Ceproex Dose
The ceporex dosage should be reduced if renal function is markedly impaired.
Ceporex Syrup Capsules Tablets Injections Contraindications
Ceporex (Cephalexin) contraindicated in patients known with allergy to the cephalosporin group of antibiotics. Meanwhile, severe systemic infections which require parenteral cephalosporin treatment should not treated orally during the acute stage.
Ceporex (Cephalexin) Warnings & Precautions
Hypersensitivity Reactions
Cephalexin should given cautiously to patients who have shown hypersensitivity to other drugs. Meanwhile, Cephalosporins should be given with with caution to penicillin-sensitive patient. As there is some evidence of partial cross-allergenicity between the penicillin and cephalosporins. But, patients have had severe reactions to both drugs. However, If the patient experience an allergic reaction Cephalexin should discontinued treatment with the appropriate agents initiated.
Renal Impairment
On the other hand, Cephalexin should administered with caution in the presence of markedly impaired renal function as it is excreted mainly by the kidneys. Most importantly, careful clinical and laboratory studies should made. Because the safe dosage may be lower than that usually recommended.
Direct Coombs Test
Positive direct coombs tests have reported during treatment with cephalosporin antibiotics. Further, haematoiogical studies,or in transfusion cross-matching procedures when antiglobulin tests are performed on the minor side. Or in coombs testing of newborns whose mothers have received cephalosporin antibiotics before parturition. It should recognized that a positive coombs test may due to the drug.
False-Positive Glycosuria Reaction
A false positive reaction for glucose in the urine may occur with Benedict’s or Fehling’s solution or with copper sulphate test tablets. However, Tests based on glucognised oxidation reactions may be safely used.
- Cephalexin, 125 mg/5 ml. granules for suspension
- And Cephalexin, 250 mg/5 ml. granules for suspension
- Cephalexin, 125 mg/1.25 ml. granules for paediatric drops
Sucrose
Meanwhile, These products contain sucrose. So, most importantly, patients with rare hereditary problems of fructose intolerance glucosegalactose malabsorption or sucrase-isomaltases insufficiency should not take this product.
Ceporex (Cephalexin) Drug Interactions
- Bacteriostatic Antibiotics
As cephalosporins like cephalexin or only active against proliferating microorganisms. They should not be combined with bacteriostatic antibioltics.
- Uricosuric Drugs
Concomitant use of ericosuric drugs suppresses renal drug elimination. As a result cefalexin plasma levels are increased are increased and sustained for longer periods.
- Metformin
A potential interaction between cephalexin may result in an accumulation of metformin and could result in fatal lactic acidosis.
- Increased Risk Of Nephrotoxicity
If associated with highly potent diuretics or other potentially nephrotoxic antibiotics, polymyxin, cephalosporins may show higher nephrotoxicity.
- Oral Anticoagulants
Combined use of cephalosporins and oral anticoagulants may prolong prothrombin time.
- Typhoid Vaccine
Cephalexexin like other antibiotics with antibitoics with antibacterial activity against salmonella typhoi organisms, may interfere with the immunological response to the liver typhoid vaccine. So the approprate period of time should elapse between the administration of the last dose of the antibiotic and the live typhoid vaccine.
- Oral Contraceptives
On the other hand, Cephalexin may reduce the effects of oral contraceptives.
- Pregnancy And Lactation
Most importantly, Ceprox should administered with caution during pregnancy. Meanwhile, there is no experimental or clinical evidence of teratogenic effects attributable to cephalexin. On the other hand, Cephalexin also excreted in human milk in low concentrations. Therefore it should used with caution in nursing mothers.
Ceporex Syrup Tablet Capsules Injections Side Effects Details
Cephalexin Side Effects include Gastro intestinal disturbances such as
- Nausea
- Vomiting
- Diarrhoea
- Abdominal discomfort
However, the most common of these effects is diarrhoea. But this is rarely severe enough to warrant cessation of therapy. On the other hand, Transient hepatitis and cholestatic jaundice have rarely been reported.
Furthermore, Cephalexin Side Effects also shown Allergic reactions. These includes reaction such as
- Rash
- Urticaria
- Angioedema
- Erythema multiforme
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis.
- Genetal and Anal Pruritus
- Genital candidiasis
- Vaginitis and Vaginal discharge
- Dizziness
- Fatigue
- Headache
- Agitation
- Confusion
- Hallucinations
- Arthralgia
- Arthritis
- Joint Disorders
Meanwhile, as with other cephalosporins interstital nephritis has rarely reported. However, Eosinophilia, neutropenia, thrombocytopenia and slight elevations in AST and ALT have reported. However, as with other broad spectrum antibiotics prolonged use may result in the overgrowth of non-susceptible organisms like candida. Meanwhile, this may present as vulvo-vaginitis.
On the other hand, there is a possibility of development of pseudomembranous colitis. Therefore it is important to consider its diagnosis in patients who develop diarrhea while taking cefalexin. However, It may range in severity from mild to life threatening with mild case usually responding to cessation of therapy. In addition, appropriate measures should taken with moderate to severe cases.
Ceporex Tablets Syrup Capsules 500 MG Suspension Injections Overdosage Symptoms And Treatment
Symptoms
Furthermore, Ceporex (Cephalexin) Overdosage Symptoms may include
- Nausea
- Vomiting
- Epigastric distress
- Diarrhoea
- Haematuria
Treatment
Firstly, general management consists of close clinical and laboratory monitoring of haematological renal and hepatic functions. And coagulation status until the patients is stable. Meanwhile, Serum levels of cephalexin can reduced by haemodialysis or by peritoneal dialysis.
Ceprorex (Cephalexin) Tablets 250 MG, Syrup, Injection Storage Instructions
Most importantly, always keep ceporex tablets, syrup, tablets, injections out of the reach of your children. On the other hand, store the product in a cool but dry place. Meanwhile, avoid from direct sun light and heat.
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Ceporex (Cephalexin) Tablets 250mg, Capsules 500mg, Injection 1G, Syrup 125ML, Suspension 250ML Price In Pakistan India USA