Diclofenac Potassium(M.S) Antiflam Tablets Uses Dosage Side Effects Benefits Formula Ingredients Price Details

Diclofenac Potassium (MS) (Antiflam Tablets) Uses Details

Diclofenac Potassium (Antiflam Tablets) is knows as a benzeneacetic acid derivative. Meanwhile it is a non inflammatory drug.  The chemical name is 2(2,6 – dichloropheny) amino benzeneacetic acid, monopotassium salt. On the other hand, molecular weight is 334 25. Its molecular formula is  CC14 H10 Cl2 NKO2. Meanwhile, it resembles both flurbiprofen and meclofenamate. It reduced fever and inflammation and relieves pains.

More Useful Medicine:  Ceporex Tablets Capsules Syrup Suspension Uses Dosage Side Effects Benefits Formula Price

Diclofenac Potassium (MS) Antiflam Tablets Uses

Diclofenac Potassium (Antiflam Tablets) uses for the treatment of the symptoms like.

• For treatment of primary dysmenorrhea
• For relief of mild to moderate pain
• Relief of the signs and symptoms of osteoarthitis
• For relief of the signs and symptoms of rheumatoid arthritis

Diclofenac Potassium (Andtiflam Tablets) Dosage

Use the lowest effective dose for the shortest duration consistent with individual patients treatment goals. Meanwhile, after observing the response to initial therapy with it, the dose and frequency should  adjusted to suit an individual patients needs. On the other hand, for treatment of pain or primary dysmenorrhea; The recommended dosage is 50 mg t.i.d. With experience physicians may find that in some patients an initial dose of 100 MG tab, following by 50 mg doses, will provide better relief . However, for the relief of rheumatoid arthritis; The recommended dosage is 150  200 mg/day in divided doses, 50 mg t.i.d.or q.id.

Diclofenac Potassium (Antiflam Tablets ) Contraindications

Most importantly, the medications is contraindicated in patients with known hypersensitivity to Diclofenac. On the other hand, It should given to patients who have experienced asthma, urticaria or allergic type reactions after taking Aspirin or other NSAIDs. However, Severe, rarely fatal, anaphylactic like reactions to NSAID have reported in such patients. In addition, it also contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Diclofenac Potassium (Antiflam Tablets) Precautions

General

Firstly, Diclofenac Potassium (Antiflam) cannot expected to substitute for corticosteroids or to treat corticsteroid insufficiency. Meanwhile, Abrupt discontinuation of corticosteroids may lead to disease exacerbation. Meanwhile, Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids. The pharmacological active of the medication in reducing fever and inflammation may diminish the utility of these diagnostic signs in detecting complication of presumed noninfectious , painful conditions.

Hematological Effects

Similarly, Anemia is sometimes seen in patients receiving NSAID, including this medicine. However, this may due to fluid retention, occult or group GI blood loss or an incompletely described effect upon erythropoiesis. Meanwhile, patients on long term treatment with NSAID, including it should have their hemoglobin or hematocrit checked if they exhibit any signs of anemia. NASID inhibit platelet aggregation and have shown to prolong bleeding time in some patients. Unlike Aspin, their effect on platelet function quantitatively less, of shorter duration and reversible. Meanwhile, Patients receiving this product who may be adversely affected by alterations in platelet function, such as those with coagulation disorders or patients receiving anticoagulants, should carefully monitored .

Preexisting Asthma

Furthermore, patients with asthma may have Aspirin sensitive asthma. Meanwhile, the use of Aspirin in patients with Aspirin sensitive asthma has associated with severe bronchospasm which can fatal. Since cross reactive, including bronchospasm, between Aspirin and other Non steroidal noninflammatory  drugs has reported in  such Aspirin sensitive patients. On the other hand, Diclofenac Potassium Aspirin should not administered to patients with this from of Aspirin sensitivity. And should used with caution in all patients with preexisting asthma.

Diclofenac Potassium (Antiflam) Use In Pregnancy

Pregnancy Category C; That is to say, Reproductive studies conducted in rats and rabbits have not demonstrated evidence of developmental abnormalities; However, animal reproduction studies not always predictive of human response. Therefore no adequate and well controlled studies in pregnancy women available yet. Non-teratogenic Effects; Because of the known effects of Non steroidal anti in inflammatory drugs on the fetal cardiovascular system (closure of ductus arteriosus) use during pregnancy (particularly late pregnancy ) should avoided .

Use During Lactation

Further it is not known whether this drug  excreted in human milk. Because many drugs are excreted in human milk because of the potential for serious adverse reactions in nursing infants from this medication. So, a decision should  made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Diclofenac Potassium (Antiflam) Tablets Drug Interactions

Aspirin;

Firstly,  When Diclofenac Potassium (Atniflam) is administered with Aspirin. As a result its protein binding is reduced. The clinical significance of this interaction is not known; however , as with other NSAID , concomitant administration of the medicine and Aspirin is not generally recommended because of the potential of increased adverse effects.

Methotrexate;

After that, NSAID have been reported to competitively inhibit Methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of Methotrexate .  Caution should be used when NASID are administered concomitantly with Methotrexate.

Cyclosporine;

Similarly it , like any other NSAID, may affect renal prostaglandins and increase the toxicity of certain drugs. Therefore, concomitant therapy with its use there may increase Cyclosporine nephrotoxicity. Caution should be used when it is administered concomitant with Cyclosporine.

ACE Inhibitors;

Similarly, Reports suggest that NSAID may diminish the antithypertensive effect of ACE inhibitors. However, This interaction should be given consideration in patients taking NSAID concomitantly with ACE inhibitors.

Furose – mide;

Clinical studies, as well as post marketing observations , have shown that it can reduce the natriuretic effect of Furose – mide and Thiazides in some patients. Meanwhile, This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAID, the patients should be observed closely for signs of renal failure as well as to assure diuretic efficacy.

Lithium;

Furthermore, NSAID have produced an elevation of plasma Lithium levels and a reduction in renal Lithium clearance. Meanwhile, The mean minium Lithium concentration increased 15 and the renal clearance was decreased by approximate 20. However, these effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAID and Lithium are administered concurrently, subjects should be observed carefully for signs of lithium tooxicity.

Warfarin;

Similarly, The effects of Warfarin and NSAID  on GI bleeding are synergistic. Such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alon.

CYP2C9 Inhibitors or Inducers;

Firstly, Diclofenac is metabolized by cytochrome P450 enzymes, predominantly by CYP2C9.  So, Co administration of the medicine with  CYP2C9 inhibitors (e.g Voriconazole) may enhance , the exposure and toxicity of Diclofenac Potassium (Antiflam). However, co administration with  CYP2C9 inducers (e.g Rifampin) may lead to compromised efficacy of Diclofenac. Therefore, Use caution when dosing of the product with CYP2C9 inhibition or inducers, a dosage adjustment may be warranted.

Diclofenac Potassium (Antiflam Tablets) Side Effects

Side Effects On Whole Body:

• Fever
• Infection
• Sepsis
• Abnormal renal function
• Anemia
• Dizziness
• Edema
• Elevated liver enzymes
• Headaches
• Increased bleeding time
• Pruritus
• Rashes
• Tinnitus

Cardiovascular System Disorders:

• Congestive heart failure
• Hypertension
• Tachycardia
• Syncope

Digestive System Disorders:

• Abdominal pain
• Constipation
• Diarrhea
• Dyspepsia
• Flatulence
• Heartburn
• Nausea
• Vomiting
• Dry mouth
• Esophagitis
• Gastric ulcers
• Peptic ulcers
• Gastrointestinal bleeding
• Glossitis
• Hematemesis
• Hepatitis
• Jaundice

Hemic And Lymphatic System Side Effects:

• Ecchymosis
• Eosinophilia
• Leukopenia
• Melena
• Purpura
• Rectal bleeding
• Stomatilis
• Thrombocytoprnia

Metabolic And Nutritional:

• Weight Changes

Nervous System Disorders:

• Anxiety
• Asthenia
• Confusion
• Depression
• Dream abnormalities
• Drowsiness
• Insomnia
• Malaise
• Nervousness
• Paresthesia
• Somnolence
• Tremors
• Vertigo

Respiratory System Side Effects:

• Asthma
• Dyspnea

Skin And Appendages Disorders

• Alopecia
• Photo sensitivity
• Sweating increased

Special Senses Disorders

• Blurred vision

Urogenital System Disorders

• Cystitis
• Dysuria
• Hematuria
• Interstitial nephritiis
• Oilguria /polyuria
• Proteinuria
• Renal failure

 Overdosage Symptoms & Treatment Guide

In addition, Symptoms following acute NSAID overdosage are usually limited to lethargy

• Drowsiness
• Nausea
• Vomiting
• Epigastric pain,

But, these are generally reversible with supportive care. In addition in some patients Gastrointestinal bleeding can occur. On the other hand, Hypertension, acute renal failure, respiratory depression and coma may also occur. But are Anaphylactoid reactions have reported  with therapeutic ingestion of NSAID and may occur following an overdosage . Meanwhile, Patients should managed by symptomatic and supportive care following an NSAID overdose. However, there are no specific antidotes. Meanwhile, Emesis and activated charcoal (60 to 100 g in adult, 1 to 2g /kg in children ) and osmotic cathartic may indicated in patients seen within 4 hours of ingestion with symptoms or following a large overdose ( 5 to 10 time the usual dose). Forced diuresis , alkalinization of urine , hemodialysis or hemoperfusion may not be useful due to high protein binding.

Antiflam Tab Storage Instructions

Most importantly protect the medicine from direct sun light and heat. On the other hand, store it on a cool and dry place under 30 C temperature. And most importantly, always remember to keep your all medical products out of the reach of your children because it may become a risk to their life.

More Medicine Information:  Cipralex Tablets 10 MG, 15 MG, 20 MG Uses, Dosage, Side Effects Benefits Formula Ingredients Price

Diclofenac Sodium (Antiflam) 50 MG, 75 MG Tablets Price (Rs. 166 PKR)

 

Disclaimer

All the details of the medicine provided on this website Pharmacy Online Here are only for informational purposes and there is no intent to substitute for professional medical advice, diagnostic, and treatment purposes. Therefore, always get medical advice from any qualified healthcare provider doctor, or pharmacist for any questions about your medical conditions, symptoms, or disorder. So do not disregard the medical advice of your professional healthcare provider or delay it simply because of the information your read here on this website.  Note:– Always Use Any Type Of Medicines Only Under The Supervision Of A Professional Healthcare Provider, Doctor, Or Pharmacist.