Movax Tablets Uses Dosage Side Effects Price Details
Movax tablets contains a useful life saving medicine used for several pain treatments named Tizanidine Hydrochloride. Meanwhile tizanidine is a centrally action alpha-2 adrenergic agonist which is a skeletal muscle relaxant. Its chemical name is 5-chloro -4 (-imidazoline- 2-ylamino ) -2,1,3 benzothiadiazole hydrochloride.
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Pharmacological Properties Of Movex Tablets
Absorption And Bioavailability
Tizanidine is rapidly and almost completely absorbed, reaching peak plasma concertation in approx. 1 hours Although Tizanidine is well absorbed, the absolute oral bioavailability of Tizanidine is about 30-40% due to extensive first pass metabolism
Distribution
Tizanidine is only about 30% bound to plasma proteins
Metabolism
Tizanidine undergoes rapid and extensive metabolism in the liver. Tizanidine metabolism are not know to be active.
Elimination
Excretion primarily is via renal route (approx. 70% of the administered dose). the elimination half - life of Tizanidine for plasma is 2-4 hours in patients Concomitant food intake has no influence on the pharmacokinetic profile of Tizanidine tablets
Movax Tablets Tizanidine Uses & Indications
Movax Used For Painful Muscle Spasms
- Associated with static and function disorders of the spine (cervical and lumber syndromes) Following surgery e.g. for hesitated intervertebral disc or osteoarthritis of the hip
- Musca spasms associated with accidental trauma
Spasticity Due To Neuroglial Disorders
Like multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebrovascular accidents and cerebral palsy
Tab Movax Tablets Tizanidine Dosage
- Dose For Oral Administration
The effect of Movax (Tizanidine ) on spasticity is maximum within 2-3 hours of dosing and it has a relatively short duration of action. The timing and frequency of dosing should therefore be tailored to the individual and Tab Movax (Tizanidine ) should be given in divided doses, up to 3-4 times daily, depending on the patients need. There is considerable variation in response between patients so careful titration in necessary. Care should be taken not to exceed the dose producing the desired therapeutic effect. It is usual to start with a single dose of 2 mg increasing by 2 mg increment at not less than half - weekly intervals. The total daily dose should not exceed 36 mg, although it is usually not necessary to exceed 24 mg daily
Movax Tablets Dose Used For Elderly Patients
Experience in the elderly is limited and use to Tizanidine is not recommended unless the benefit of treatment clearly outweighs the risk. Pharmacokinetic data suggest that renal clearance in the elderly may be decreased by up to three folds
Movax Tablets Dose Uses For Children Patients
Experience with Tizanidine in patient under the age of 18 years is limited. Movax (Tizanidine ) is not recommended for use in children
Movas Used For Patients With Renal Impairment
In patients with renal insufficiency (creatinine clearance <25 ml/min)treatment should be start with 2 mg once daily with slow titration achieve the effective dose. dosage increases should be in increment of no more than 2 mg according to tolerability and effectiveness. It is advisable to slowly increase the once daily dose before increasing the frequency of administration. Renal function should be monitored as appropriate in these patients
Dose For Patients with Hepatic Impairment
Movax (Tizanidine ) is contraindicated in patients with significantly impaired hepatic function. Meanwhile such patients can only use the medicine after your pharmacist or doctor has suggest you with a specific dose.
Movax Tablets Contraindications
Movax tablets use contraindicated in patients with hypersensitivity to tizanidine or any other ingredient used in the formula of the medicine. In addition, the use of movax tablet tizanidine in patients with significantly impaired hepatic functions also contraindicated. Because tizanidine extensively metabolized by the liver in human.
Movax Tablet Precautions & Warnings
Tizanidine Movax Tablet Use In Renal Impairment
Firstly the patients with renal impairment may require lower doses. Therefore, caution should excised when using tab Movax the tizanidine in such patients
Movax Tablet Used For Liver Functions
Hepatic dysfunction has reported in association with tizanidine. Therefore, it recommended that liver function tests should monitored for the first four months in all patients. And also in those who develop symptoms suggestive of liver dysfunctions such as. Unexplained nausea, anorexia, or tiredness. So, the treatment with Tizanidine should discontinued if serum levels of SGPT and SGOT persistently above three times the upper limit of normal range.
Movax Tablet Drug Interactions
As Movax (Tizanidine) may induce hypotension may potentiate the effect of antihypertensive drugs, including diuretics, and caution should therefore be exercised in patients receiving blood pressure lowering drugs. Caution should be also exercise when Movax (Tizanidine) is used concurrently with B-blocking drugs or digoxinas the combination may potentiate hypotension or bradycardia. Most importantly, the caution should be exercised when Movax (Tizanidine ) is prescribed with drugs know to increase the QT interval
Use In Pregnancy & Lactation
Pregnancy Category C. The safety of Movax (Tizanidine ) in pregnancy has not been established and its safety in breast-fed infants of mothers receiving Movax (Tizandine) is not know. Therefore Movax (Tizanidine ) should not be used in pregnant or nursing mothers unless the likely benefit clearly outweighs the risk
Movax Tablets Tizanidine Side Effects
The most frequently reported adverse events occurring in association with Movax (Tizanidine ) include drowsiness, fatigue, dizziness, somnolence, dry mouth, nausea, gastrointestinal disturbance, muscle weakness, insomnia, sleep disorder, hypotension and a reduced in blood pressure. With slow upward titration of the dose of Movax (Tizanidine ) these effect are usually not severe enough to require with discontinuation of treatment. Increase in hepatic serum transaminases. Which are reversible on stopping treatment, have occurred, Infrequent cause of acute hepatitis have been reported. Muscle weakness has been reported infrequently, although in controlling clinical trials it was clearly demonstrated that Movax (Tizanidine ) dose not adversely effect muscle strength. Allergic reactions (e.g. pruritus and rash ) have rarely been reported
Movax Tablet Tizanidine Overdosage Symptoms & Treatment
Symptoms:
Nausea, vomiting, hypotension, dizziness, somnolence, miosis, restlessness, respiratory distress, coma
Treatment:
General supportive measures are indicated and an attempt should be made to remove undigested drug from the gastro-intestinal tract using gastric lavage or activated charcoal. The patients should be well hydrated. Further treatment should be symptomatic.
Movax Tizanidine Medicine Storage Instructions
First of all always keep your tizanidine medications out of the reach of your child to protect their life from any type of severe side effects. On the other hand, Store the tablets below 30 C temperature. Similarly protect it from direct sun light and heat exposure.
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