Onset Tablets Injection Uses Dosage Administration Side Effects Benefits Price

What Are Onset 8 Ondansetron Tablets Injections & Its Uses?

Onset 8 Tablets Injections contains Ondansetron Hydrochloride in it. It mainly used to prevent vomiting and nausea which caused in several patients after any type of surgery.

More Medications:  Vastarel MR 35 MG Tablets Uses Dosage Side Effects Benefits Ingredients Formula Price

What Is Ondansetron And What It Used For?

Ondansetron Hydrochloride is a selective antagonist of the serotonin receptor subtype, -HT3. On the other hand its precise mode of action in the control of nausea and vomiting caused by cancer chemotherapy, the radiation therapy or because of any surgery. Cytotoxic chemotherapy and radiotherapy  associated with the release of serotonin (5-HT). From enterochromaffin cells of the small intestine, presumably initiating a vomiting reflex through stimulation of 5-HT3, Receptors located on vagal afferents . Furthermore, Ondansetron also can block the initiation of this reflex. Furthermore, activation of vagal afferents may also cause a central release of serotonin from the chemoreceptor trigger zone of the fourth ventricle. Thus, the antiemetic effect of ondansetron of 5-HT3 receptors on neurons systems or both. However the mechanisms of ondansetron’s antiemetic action in postoperative nausea and vomiting are not known. In most parts of the world it sold under the brand name of Onset 8 Tablet and Zofran. Ondansetron first found during studies in USA while it first approved to use in medicines in year 1990.

Uses In Urdu Hindi

Onset 8 Tablets Injections Uses & Indications

It used for the prevention of nausea and vomiting associated with emetogenic chemotherapy, including high dose cisplatin and radiotherapy. On the other hand it also indicated for the prevention and treatment of post-operative nausea and vomiting.

Onset Ondansetron Tablets Injections Contraindications

In patients with a history of hypersensitivity to the products or any components of Onset Tablets And Injection formulations contraindicated.

All Warnings & Precautions Details

It is not effective in preventing motion-induced nausea and vomiting. However no experience available in patients who clinically jaundiced. On the other hand the clearance of an 8 mg intravenous dose of Ondansetron significantly reduced. And the serum half-life significantly prolonged in subjects with severe impairment of hepatic function. On the other hand In patients with moderate to severe hepatic function, reductions in dosage therefore recommended. And a total daily dose of 8 mg should not exceeded. This may given as a single i.v. or oral dose.

Onset 8 Tablets Injections Use In Pregnancy And Lactation

The safety of Ondansetron during pregnancy has not been pregnancy has not been established. Most importantly it should not be used if out weigh the possible risk to the fetus. On the other hand it excreted in the milk of lactating rats. It is not known if it is excreted in human milk. However, nursing is not recommended during treatment with this drug.

Onset 8 Use In Children

Insufficient information available to provide dosage recommendations for children 3 years of age or younger.

Onset Ondansteron 8 Injection Tablets Side Effects

Onset Injection Tablet has been administered to over 2500 patients worldwide in controlled clinical trials and has been well tolerated. However The most frequent adverse events reported in controlled clinical trials noticed headache (11 % ) and constipation (4 %). Meanwhile Other adverse events include sensations of flushing or warmth (1 %).

Metabolic :

Transient increases of AST and ALT of over twice the upper limit of normal in approximately 5 % of patient’s. On the other hand this increase did not appear to be related to dose or during of therapy. There have been reported of liver failure and death in patients with cancer receiving concurrent medications including potentially hepatotoxic cytotoxic chemotherapy and antibiotics.

CNS:

There have been rare reported of seizures.

Hypersensitivity:

Rare cases of immediate hypersensitivity reaction sometime severe, including anaphylactic, bronchospasm, urticaria and angioedema  reported.

Cardiovascular:

Rare cases reported of tachycardia angina. Bradycardia, hypotension, Syncope and electro cardio graphic alteration.

Dermatological:

Rash has occurred in approximately 1 % patients receiving Ondansetron.

Special Senses:

Rare cases of transient visual disturbances reported during or shortly after i. v. administration of Ondansetron. Particularly at rates equal to or greater then 30 mg in 15 minutes. Local Reactions: Pain redness and burning at the site of injection have been reported.

Other:

Some cases reported of abdominal pain weakness and xerostomia.

Onset 8 Ondansetron Tablet Injections Dosage Administration

Chemotherapy Induced Nausea And Vomiting:

Onset should given as an initial dose prior to chemotherapy. Followed by a dosage regimen to the anticipated severity of emetic response caused by different cancer treatments. However the route of administration and dosage of Ondansetron should flexible in the range of 8 to 32 mg a day.

Onset Dose For Adults

Chemotherapy (e.g., Regimens Containing Cisplatin): Ondansetron has shown to be effective in the following dosage schedules for the prevention of emesis during the first 24 hours following chemotherapy Initial Dosage : 8 mg infused I.v. over 15 minutes, given 30 minutes prior to chemotherapy. Or 8 mg infused I.V. Over 15 minutes, given 30 minutes prior to chemotherapy. In addition followed by 1 mg/h by continuous infusion for to 24 hours. Or 32 mg diluted in 50 minutes given 30 minutes prior to chemotherapy.

Post-Chemotherapy;

After the first 25 hours 8 mg orally every 8 hours for up to 5 days. No significant differences in terms of emesis control or grade of nausea have demonstrated between the 32 mg single dosage. On the other hand the 8 mg single dosage or the 8 mg dose followed by the 24 hour 1 mg/hour continuous infusion. However, in some studies conducted in patients receiving medium or high doses of cisplatin chemotherapy, the 32 mg single dosage has demonstrated a statistically significant superiority over the 8 mg single dose with regard to control or emesis. The efficacy of Ondansetron in highly emetogenic chemotherapy may enhanced by the addition of a single i.v. dose of dexamethasone sodium phosphate, 20 mg administered prior to chemotherapy.

Post- Chemotherapy:

8 mg tablet orally twice daily for up to 5 days.

Onset Dose For Children:

Clinical experience of Ondansetron in children currently limited. However, Ondansetron seem effective and well tolerated when given to children 4 to 12  years of age. On the other hand Ondansetron injection should given i.v. at a dose of 3 to chemotherapy. However after therapy, one Ondansetron 4 mg tablet should given orally every 8 hours for up to days.

Geriatrics:

Efficacy and tolerance in patients aged over 65 years were similar to that seen in younger adults indicating no need to alter dosage schedules in this population.

Radiotherapy Induced Nausea And Vomiting:

Onset Dosage For Adults:

Initial- Radiotherapy: Onset 8 mg tablet orally every 8 hours before radiotherapy. Post-Radiotherapy: Onset 8 mg tablet orally every 8 mg hours for up to 5 days after a course of treatment.

Post Operative Nausea And vomiting:

Onset Dose For Adults

For prevention of post operative nausea and vomiting it may administered as at 16 mg given orally 1 hour prior to anesthesia. On the other hand Approximately a single dosage of 4 mg may be given by slow i.v. injection at induction of anesthesia.

Onset Dose For Children:

No experience in the use of Ondansetron in the prevention and treatment of post operative nausea and vomiting in children.

Geriatrics:

Limited experience in the use of this medicine in the prevention and treatment of post operative nausea and vomiting in the elderly.

Impaired Renal Function:

No alteration of daily dosage frequency of dosage or route of administration required.

Impair Hepatic Function:

The clearance of an 8 mg i.v. dose was significantly reduced and the serum half life significantly prolonged in subjects with moderate to severe hepatic function. Reductions in dosage therefore recommended and a total daily dosage of 8 mg should not exceeded. However this may given as single i.v. or oral dose.

Onset 8 Ondenstron Tablet Injection Overdosage Symptoms And Treatment

Symptoms and Treatment:

At present a little Onset 8 MG Over dosage information available yet. And total daily doses as large as 252 mg have administered with only mild side effects. However there is no specific antidote for this medication. Therefore in cases of suspected over dosage symptomatic and supportive therapy should given as appropriate. Sudden blindness of 2 to 3 minutes duration plus severe constipation occurred in patients that administered 72 mg of Ondansetron i.v. single dose. Hypotension and faintness occurred in another patient that took 48 mg of oral Ondansetron. Following infusion of 32 MG over only a 4 minute period of time. A vasovagal episode with transient second degree heart block observed. In all instances the events resolved completely.

Stability

Onset Injection is stable at room temperature under normal lighting conditions for 48 hours after dilution with the following i.v. fluids 0.9 % sodium chloride injection, 5 % Dextrose injection, 5 % Dextrose and 0.45 % sodium chloride injection, and 3 % sodium chloride injection. Although onset injection is chemically and physically stable when diluted as recommended. Sterile precautions should observed because diluents generally do not contain preservative. After dilution, do not use beyond 24 hours.

Onset 4 MG Ondansetron HCL Medicine Storage Instructions

Store the Injection below 2 C to 30 C temperature. On the other hand the Tabs storage temperature within  15 C to 25 C. The injection must be protect from frozen. On the other hand protect the tablets from sun light and heat. Most importantly always keep all the medical products out of the reach of the children.

More Medical Information:  Leozin Tablet 5 MG Uses, Dosage Administration, Side Effects Benefits Formula Ingredients Price

Onset Ondansetron 8 MG 4 MG Injection, Tablet Price

• Price In USA= 4 USD
• Price In India= 128 INR
• Price In Pakistan= 155 PKR

 

Disclaimer

All the details of the medicine provided on this website Pharmacy Online Here are only for informational purposes and there is no intent to substitute for professional medical advice, diagnostic, and treatment purposes. Therefore, always get medical advice from any qualified healthcare provider doctor, or pharmacist for any questions about your medical conditions, symptoms, or disorder. So do not disregard the medical advice of your professional healthcare provider or delay it simply because of the information your read here on this website.  Note:– Always Use Any Type Of Medicines Only Under The Supervision Of A Professional Healthcare Provider, Doctor, Or Pharmacist.