Tonoflex P Tablets Best Medicine For Chronic Pain

Tonoflex P Tablets a combined formulation of two medications named Tramadol HCL and Paracetamol. Paracatamol is an analgesic and antipyretic agent. While on the other hand Tramadol HCL is a centrally acting analgesic with a unique dual mechanism of action within the CNS. It also exerts agonistic properties at opiate receptors and interferes with neurotransmitter reuptake.

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TonoFlex P Tablets Composition

Each TonoFlex P Tablet contains :

Tramadol HCl Ph. Eur<————-> 37. 5 mg

Paracetamol BP <——————-> 325 mg

Tonoflex P Indications

Tablet Tonoflex P indicated for the short term (Less than 5 days ) management of acute pain. Meanwhile, different pharmacists or doctors consider it one of the best medicine for acute pain chronic pain symptoms like Knee pain, sinus headache pain. On the other hand, some doctors also find it the Best Pain Medicine for Rheumatoid Arthritis, For Teething Pain, For Wrist Pain, For Back Muscle Pain, Neck Pain as well as used to relieve pain after the surgery.

TonoFlex P Contraindications

Most importantly, Tramadol + paracetamol combination contraindicated in patients with a known hypersensitivity to Tramadol paracetamol or other opioids such as codeine. On the other hand, It also contraindicated in cases of severe liver function impairment. Also in acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids, or psychotropic medicine. So it should not be administered to patients who are receiving monoamine oxidase inhibitors or within two weeks of their withdrawal.

In Addition, Tramadol + Paracetamol combination must not used for narcotic withdrawal treatment. On the other hand, Tramadol + Paracetamol combination should not given to patients with respiratory depression. Furthermore, it must not use especially in the presence of cyanosis and excessive bronchial secretions. Similarly, Tramadol + paracetamol combination should not use in patients with increased intracranial or central nervous system depression due to head injury or cerebral disease.

TonoFlex P Best Chronic Pain Medicine Warnings

Dosage in excess of those recommended may cause severe liver damage. So Patients suffering from liver or kidney disease should take paracetamol containing products under medical supervision.

Serious Skin Reactions

Rarely, acetaminophen (paracetamol) may cause serious skin reactions such as acute generalized exanthematous Pustulosis, Stevens johnson Syndrome, and toxic epidermal necrolysis which can be fatal. Meanwhile, patients should informed about the signs of serious skin reactions. And use the drug should discontinue at the appearance of skin or any other sign of hypersensitivity

Seizures

Seizures have reported in patients receiving Tramadol at dosage within the recommended dosage range. So the risk of seizure enhanced in patients exceeding the recommended dose. Or in patients taking anti tricyclic antidepressants or other tricyclic compounds Like. Promethazine, selective serotonin reuptake inhibitors, MAO inhibitors, and neuroleptics

Drug Abuse And Dependence

Although Tramadol has a low dependence potential, tolerance, psychic and physical dependence of the morphine type may develop with long term use.

Tonoflix P Tablets Effects on Ability to Drive or Operate Machinery

Tramadol may affects reactions to the extent that driving ability to operate machinery may be impaired. This applies particularly in conjunction with other psychotropic medicines including alcohol.

Tonoflex P Dosage Administration

To be used in adults and children over 16 years of age. Do not exceed the recommended Tonoflix P Tablets dose.

TonoFlix P Dose For Acute Chronic Pain

2 tablets every 4 to 6 hours needed for pain relief. Most importantly do not exceed 8 tablets per day.

TonoFlex P Dosage For Renal Impairment

In patients with creatinine clearance less than 30ml/min. So it recommended that the dosing interval be increased not to exceed 2 tablets every 12 hours.

Tonoflex P Tablets Side Effects

The most frequently reported Tonoflix P Tablets side effects of the gastrointestinal central nervous system. Like

Gastrointestinal

• Nausea
• Abdominal pain
• Constipation
• Flatulence
• Vomiting
• Dry mouth
• Dyspepsia
• Diarrhea

Central Nervous System And Psychiatric

• Dizziness
• Headache
• Nervousness
• Anxiety
• Agitation
• Euphoria
• Emotional liability
• Hallucinations
• Hypertonia
• Tremor
• Somnolence
• Insomnia
• Anorexia
• Anxiety
• Confusion
• Euphoria
• Nervousness

Other reported tonoflix tablets side effects including pruritus, fatigue, upper respiratory tract infection, increased sweating, hot flushes, rashes, and asthenia.

On the other hand side effect reported with the use of Tramadol include; increased liver enzyme values, postural hypotension or cardiovascular collapse, and the potential for Toxic Epidermal Necrolysis and Stevens johnson Syndrome.

Paracetamol may cause an allergic reactions to skin rash. The rash usually appears as red areas or allergic wheals. And may accompanied by fever and involvement of the mucous membranes. The use of paracetamol has associated with the occurrence of neutropenia, pancytopenia, and leucopenia. Lastly, you must stop further use of the product and must immediately contact your doctor for further help if you notice any of the above said medication side effects.

Tonoflix P Special Precautions

Do not co-administer Tonflex P with other Tramadol or paracetamol containing products. On the other hand, Tramadol +combination should not take with alcohol-containing beverages. The administration of Tramadol + paracetamol combination concurrently with central nervous system depressants such as alcohol, opioids, anesthetic agents, phenothiazines, tranquilizers, or sedative hypnotics is likely to intensify and prolong CNS effects.

So, Tramadol + Paracetamol combination should use with caution in patients with impaired renal functions. And in patient’s renal functions or in patients with impaired hepatic functions. Moreover in patients prone to convulsive disorder or in shock

Tonoflix P Use During Pregnancy

Safety during pregnancy and lactation has not been established. However, Tramadol has shown to cross the placentas. So you must discuss with your doctor before using this medication product if you are pregnant or planned to get pregnant.

Children

Safety and efficacy have not established for Tonoflex Tablets Use in children. So you must consult your doctor or physician for the product use in your children.

Elderly

Use with caution, reflecting the greater frequency of decreased hepatic, renal or cardiac functions. Moreover of concomitant disease and multiple drug therapy.

Tonoflix P Drug Contraindications

Concomitant administration of Tramadol + paracetamol combination and carbamazepine may cause significantly decreased Tramadol and M1 concentration. So patients receiving carbamazepine may have significantly reduced analgesic effect from the Tramadol component of Tramadol + paracetamol combination. Therefore, Concomitant administration with inhibitors of CYP206 such as fluoxetine, paroxetine, quinidine, and amitriptyline could result in some inhibitors of the metabolism of Tramadol.

On the other hand Simultaneous administration with cimetidine associate with clinically insignificant changes in serum concentrations of Tramadol. Therefore, no alteration of the Tramadol +paracetamol dosage regimen recommended for patients receiving chronic cimetidine therapy. On the other hand, Tramadol +Paracetamol combination must not combine with an MAO inhibitor. Or within 14 days of discontinuation of it as potentiation of serotonergic and noradrenergic effects may result.

In conclusion, Tramadol +paracetamol combination should used cautiously and patients should monitored carefully.

Tonoflix P Medicine Storage Instructions

Firstly, Avoid exposure to heat and direct sunlight. Store the medicine between 15 C to 30 C temperature. Most importantly always keep all the medicine out of the reach of the children. Lastly, you must read the pack for its expiry dates before using any medicines.

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Tonoflex P Tablets Price