A Comprehensive Guide Of Tonoflex P Tablets Uses, Dosage, Side Effects Price In Pakistan

What Is Tonoflex P Tablets Uses Side Effects?

Tonoflex P Tablets are a combined formulation of two medicine named Paracetamol. Paracatamol is an analgesic and antipyretic agent. On the other hand, the other is a centrally acting analgesic with a unique dual mechanism of action within the CNS. It also exerts agonistic properties at opiate receptors and interferes with neurotransmitter reuptake. Mainly, it is recommended to use it for the short-term management of acute pain but only for less than 5 days. It also acts as one of the best muscle relaxants to provide several benefits in pain. Moreover, Sami Pharmaceutical Pvt Ltd Pakistan is the manufacturer and marketer of this product worldwide.

 

Tonoflex P Tablets Uses Dosage Side Effects

Tablet Tonoflex P Uses Dosage Side Effects

 

For the treatment of pain and inflammation in the human body, this medication is thus mostly suggested by medical experts such as physicians and pharmacists for only short term management of painful symptoms. Furthermore, the medicine’s active components function as a potent combination to provide quick relief from uncomfortable sensations, inflammations, and pains. Most significantly, this medication is only offered with a physician’s prescription only worldwide. Additionally, before using this medication, you must visit a physician or pharmacist to discuss its benefits and unexpected side effects which you might face. And adhere exactly to your doctor’s or healthcare provider’s dose recommendations to get the desired results.

 

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What Ingredients are Added to its Formula Composition?

Each TonoFlex P Tablet contains     : Traml HCl Ph. Eur<——> 37. 5 mg Paracetamol BP <——> 325 mg

 

What Are Tonoflex P Uses and Indications?

Tablet Tonoflex P is suggested only for short-term (less than five days) therapy of acute discomfort and painful symptoms. Meanwhile, some pharmacists and medical professionals believe it to be one of the greatest treatments for acute pain and symptoms of chronic pain, including pains like

 

  • Knee pain
  • sinus headache pain.

On the other hand, some doctors also find it the Best Pain Medicine for Rheumatoid arthritis.

  • Teething Pain
  • Wrist Pain
  • Back Muscle Pain
  • Neck Pain
  • Postoperative pain
  • Musculoskeletal pain

 

What are TonoFlex P contraindications?

It is important to emphasize that people with a known intolerance to Tramal, paracetamol, or other medications like codeine should not use the first medication in conjunction with paracetamol. Additionally, it should not be used when there is a serious impairment of liver function, along with acute intoxication from alcohol, hypnotics, drugs, or psychotropic medications that act centrally.

Furthermore, this combination should not be given to individuals who are using monoamine oxidase inhibitors at the moment or who have just stopped taking them. The treatment of narcotic withdrawal cannot be done with Tramal and Paracetamol together. Additionally, it should not be taken if a patient has cyanosis or profuse bronchial secretions, and it is contraindicated in cases of respiratory depression.

 

TonoFlex P Best Chronic Pain Medicine Warnings

A dosage in excess of those recommended may cause severe liver damage. So patients suffering from liver or kidney disease should take paracetamol-containing products under medical supervision only and only if required.

 

  • Serious Skin Reactions

Rarely, acetaminophen (paracetamol) may cause serious skin reactions such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal. Meanwhile, patients should be informed about the signs of serious skin reactions. The use of the drug should discontinue at the appearance of skin or any other sign of hypersensitivity

 

  • Seizures

Seizures have been reported in patients receiving Tramal at a dosage within the recommended dosage range. So the risk of seizure is enhanced in patients exceeding the recommended dose. Or in patients taking anti-tricyclic antidepressants or other tricyclic compounds Like.  Promethazine, selective serotonin reuptake inhibitors, MAO inhibitors, and neuroleptics

 

  • Drug Abuse And Dependence

Although it has a low dependence potential, tolerance, psychic and physical dependence of the morphine type may develop with long-term use.

 

Effects on Ability to Drive or Operate Machinery

It may affect reactions to the extent that the driving ability to operate machinery may be impaired. This applies particularly in conjunction with other psychotropic medicines including alcohol.

 

Tonoflex P Dosage Administration

To be used in adults and children over 16 years of age. Do not exceed the recommended Tonoflix P Tablets dose. TonoFlix P Dose For Acute Chronic Pain 2 capsules are needed every 4 to 6 hours for pain relief. Most importantly, do not exceed 8 tabs per day. TonoFlex P Dosage For Renal Impairment In patients with creatinine clearance less than 30 ml/min. So it is recommended that the dosing interval be increased, not to exceed 2 tabs every 12 hours.

 

What Are Tonoflex P Tablets Side Effects?

The most frequently reported Tonoflix P Tablets side effects of the gastrointestinal central nervous system. Like

 

Gastrointestinal

  • Nausea
  • Abdominal pain
  • Constipation
  • Flatulence
  • Vomiting
  • Dry mouth
  • Dyspepsia
  • Diarrhea

 

Central Nervous System And Psychiatric

  • Dizziness
  • Headache
  • Nervousness
  • Anxiety
  • Agitation
  • Euphoria
  • Emotional liability
  • Hallucinations
  • Hypertonia
  • Tremor
  • Somnolence
  • Insomnia
  • Anorexia
  • Anxiety
  • Confusion
  • Euphoria
  • Nervousness

 

Other reported tonoflix tablets side effects include pruritus, fatigue, upper respiratory tract infection, increased sweating, hot flushes, rashes, and asthenia. On the other hand, side effects reported with the use of Tramal include; increased liver enzyme values, postural hypotension or cardiovascular collapse, and the potential for toxic epidermal necrosis and Stevens-Johnson syndrome. Paracetamol may cause allergic reactions to skin rash.

The rash usually appears in red areas or allergic wheals. And may be accompanied by fever and involvement of the mucous membranes. The use of paracetamol is associated with the occurrence of neutropenia, pancytopenia, and leucopenia. Lastly, you must stop further use of the product and immediately contact your doctor for further help if you notice any of the above-mentioned medicine side effects.

 

What Are the Special Warnings and Precautions for the Use of TonoFlexP Medicine?

It is essential not to take Tonflex P with other medicines that contain paracetamol, and it should not be taken with alcohol. When taken with central nervous system depressants such as phenothiazines, or sedatives, the effects of Traml and paracetamol can be intensified and prolonged, so caution should be taken in patients with impaired renal or hepatic functions.

Tonflex P should used with caution in patients with impaired renal or hepatic functions, as well as those prone to convulsive disorder or in shock. Safety during pregnancy and lactation has not been established, and Tramal has been shown to cross the placenta, so pregnant women should discuss its use with their doctor. Tonoflex Tablets’ safety and efficacy have not been established for use in children, and older patients should also use them with caution due to decreased hepatic, renal, or cardiac functions, as well as concomitant diseases and multiple drug therapy.

 

What Are the Drug Contraindications for Its Use?

Firstly, when the combination formulation is administered concurrently with carbamazepine. Meanwhile, it can lead to a significant decrease in the concentrations of Traml and M1. So, as a result, patients receiving carbamazepine may experience reduced analgesic effects from the Tramal component of the combination. Additionally, the concomitant use of inhibitors of CYP206. Likewise, fluoxetine, paroxetine, quinidine, and amitriptyline may inhibit the metabolism of Tramal.

In contrast, co-administration with cime tidine is associated with clinically insignificant changes in serum Tra – mal concentrations. Therefore, no dosage regimen alterations are recommended for patients on chronic cimetidine therapy. However, the combination should not be used with an MAO inhibitor or within 14 days of discontinuation. As this may potentiate serotonergic and noradrenergic effects. As a precaution, its combination should be used with care, and patients should closely monitored.

 

Tonoflix P Medicine Storage Instructions

Firstly, avoid exposure to heat and direct sunlight. Store the medicine between 15 C to 30 C temperature. Most importantly, always keep all the medicine out of the reach of children. Lastly, you must read the pack for its expiration dates before using any medicines.

 

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What Is Tonoflex P Tablets Price Worldwide?

  • Price In Rs. 312 PKR
  • Price In INR. 299 INR
  • Price In USA: $ 3 USD

 

References:

  • https://drive.google.com/file/d/0B2HYzbfSalFqakhtZVVIY1BDSTQ/view?resourcekey=0-syQ6tHA7ICnzaatawZ9ybA
  • https://oladoc.com/pharmacy/medicine/tonoflex-p-tablet-375mg-325mg
  • https://www.marham.pk/healthblog/tonoflex-p-uses-side-effects-and-dosage/
  • https://www.dvago.pk/p/tonoflex-p-tablets

 

Disclaimer

All the information about product uses, dosage side effects, formula, ingredients, indications, contraindications, drug interactions, warnings & precautions as well as it’s safe to use during pregnancy and lactation is purely based on the information available on the internet. And it is only provided here for general education and information purposes only. So do not take action about any of the information you found here because we do not guarantee the authenticity of each and every piece of information available on this website. All the information we produced is purely based on FDA-approved literature and does not substitute professional medical advice. This information is not intended to substitute medical advice, diagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical condition.

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