Wymox Tablet Capsules Uses Dosage Side Effects

Wymox Tablet is a brand name of Aamoxicillin 500 MG Capsules. It is a semisynthetic antibiotic an analog of ampicillin. Furthermore, it is populated with a broad spectrum kind of bactericidal activity against many gram-positive and gram negative micro-organisms. Meanwhile, Chemically, it is D-(-)-a- amino-p- hydroxy-benzyl penicillin.

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Wymox Tablet (Amoxicillin) Indications

Wymox (Amoxicillin 500 MG Capsules) used for in the treatment of infections due to susceptible only B-lactamase-negative strains of the designated microorganisms in the conditions mentioned.

• Infections of the ear, nose, and throat-due to Streptococcus spp. (a-and B-hemolytic strains only), S.pneumoniae, Staphylococcus spp. or H.influenzae.
• Infection of the genitourinary tract due to E Coli, P.mirabilis, or E faecalis.
• In the Infection of the skin and skin structure due to Streptococcus spp. (a-and B-hemolytic strains only), Staphylococcus spp., or E coil.
• Infections of the lower respiratory tract due to Streptococcus spp. (a-and B-hemolytic strains only), S-pneumoniae Staphylococcus spp, or H. influenzae.
• Gonorrhea, acute uncomplicated (anogenital and urethral infection) due to N. gonorrhoeae (males and females ). H.pylori eradication to reduce the risk of duodenal ulcer recurrence.

Furthermore, Wymox Use may institute prior to obtaining results from bacteriological and susceptibility studies to determine the causative organisms and their susceptibility to amoxicillin.

(Wymox Tablet Capsules ) Amoxicillin Contraindications

Wymox (Amoxicillin) is contraindicated in patients with a history of previous hypersensitivity reaction to any of the penicillins or any component of the formulation.

Wymox Tablet Uses Warnings

Serious and occasionally fatal anaphylactic reactions reported in patients receiving penicillins. Although anaphylaxis is more frequent following parenteral therapy, it has occurred in more in patients on oral penicillins. Hypersensitivity reactions are more apt to occur in individuals with a history of penicillin hypersensitivity and hypersensitivity to multiple allergens. SERIOUS ANAPHYLACTIC REACTIONS REQUIRE IMMEDIATE EMERGENCY TREA WITH EPINEPHRINE. INTRAVENOUS FLUIDS AND STEROIDS, OXYGEN AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED.

Before therapy with a penicillin, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, and other allergens. Clinical and laboratory evidence of cross allergenicity among the penicillins and partial cross allergenicity among bicyclic lactam antibiotics including penicillins, cephalosporins. cephamycins, 1 oxa B lactams, and carbapenems. If an allergic reaction occurs Wymox Tablet (Amoxicillin 500 MG Capsules) should discontinue and appropriate measures taken.

Wymox (Amoxicillin 500 MG) Capsules Precautions

Pseudomembranous colitis has been reported with nearly all antibacterial agents and may range from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antimicrobial agents. After the diagnosis of colitis has been established, therapeutic measures should be initiated. The possibility of superinfections with fungal or bacterial pathogens should be kept in mind during therapy and appropriate measure is taken.

Generalized, erythematous, maculopapular rashes following the use of amoxicillin. And ampicillin in patients with mononucleosis has frequently reported. These drugs probably should not be used in patients with the disease.

Laboratory Tests

As with any potent drugs, periodic assessment of organ system function, including renal, hepatic. And hematopoietic should be made during prolonged therapy with Wymox (Amoxicillin 500 MG Capsules).

All patients with gonorrhea should have a serologic test for syphilis at the time of diagnosis. Patients treated with Amoxicillin 500 MG should have a follow up serologic test for syphilis after 3 months.

Amoxicillin (Wymox Tablet Capsules) Use In Pregnancy

Safety for use in pregnancy has not been established. Amoxicillin readily crosses the placenta. Concentrations in cord blood have been reported to be 25 to 33 of concurrent maternal serum concentrations.

Nursing Women

Although Amoxicillin Capsules excreted in human milk in very small amounts, cautions. Caution should be exercised when Wymox Tablets administered to a nursing woman.

Amoxicillin (Wymox Tablet Capsules) Use For Children

Because of incompletely developed renal function in neonates and young children, the elimination of amoxicillin may be delayed. Dosing of Amoxicillin should be modified for children patients 12 weeks or younger (3 months ).

Geriatric Use

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function.

Carcinogenesis, Mutagenesis, And Impairment Of Fertility

Long term studies in animals have not been performed with these drugs.

Wymox (Amoxicillin) Tablets Drug Interactions

Probenecid:

Oral probenecid administered concomitantly with amoxicillin slows the rate of renal tubular secretion of amoxicillin. While peak serum concentration and half-life of amoxicillin generally increased by 30 to 60. The area under the serum concentration-time curve may be increased by 60. Aminoglycosides and penicillins are physically and chemically incompatible and can mutually inactivate each other in vitro. Penicillins can inactive aminoglycoside in vitro in serum samples from patients receiving both drugs. Which could produce falsely decreased results in serum aminoglycoside assays of the serum samples. The following adverse events have reported in association with the use of penicillin and semisynthetic penicillin derivatives.

Gastrointestinal:

Glossitis, black hairy tongue stomatitis, nausea vomiting, and diarrhea. However, these events usually associated with Wymox Tablet (Amoxicillin 500 MG) Dosage forms. Pseudomembranous colitis has reported rarely.

Hypersensitivity:

However, Two types of an allergic reaction to penicillin noted clinically, immediate, and delayed. The immediate reaction usually occur within 20 minutes of administration and ranges in severity from urticaria and pruritus to angioedema, laryngospasm, bronchospasm, hypotension, vascular collapse, and death such reaction are very rare. They usually occur after oral therapy. Another type of immediate reaction, an accelerated reaction, may occur 20 minutes to 48 hours after administration and include urticaria, pruritus, wheezing, sneezing, and fever. Although laryngeal edema, laryngospasm, and hypotension occur, fatality is uncommon.

Liver

A moderate rise in AST (SGOT), lactic dehydrogenase and alkaline phosphatase has been noted but the significance of this finding is unknown.

Hemic And Lymphatic Systems

Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have reported during therapy with the penicillins. Meanwhile, these reactions usually reversible on discontinuation of therapy and believed to hypersensitivity phenomena.

Wymox (Amoxicillin) Medication Overdose

Most importantly, in the case of Amoxicillin Overdosage discontinue Wymox Tablets. On the other hand, treat the patients symptomatically and use supportive measures as needed. Meanwhile, Amoxicillin can be removed from the circulation by hemodialysis but no by peritoneal dialysis.

Wymox (Amoxicillin) Dosage

 

Amoxicillin Dosage For Adults

• Usual dosage: Wymox (Amoxicillin) 250 mg every 8 hours.
• Severe infections or infection caused by less susceptible organisms; (Wymox Tablets) Amoxicillin 500 mg every 8 hours.
• Infection of the lower respiratory tract; Amoxicillin 500 mg Dose every 8 hours.
• Larger Amoxicillin doses may be required for persistent or severe infection Maximum recommended oral is Amoxicillin 6 g daily in divided doses.
• Gonorrhea, acute uncomplicated anogenital and urethral infection due to nonpenicillins producing Neisseria gonorrhea; Amoxicillin Capsule 3 g as a single dose plus probenecid 1 g in a single dose.

Children (<20 kg)

• The calculated Amoxicillin Dosage For Children should not exceed the recommended adult dosage. Meanwhile, Children weighing <20 kg should be dosed according to adult recommendations.
• Usual dosage For Children Is; 20 mg/kg/day in divided doses every 8 hours.
• Severe infections or infection caused by less susceptible organisms; 40 mg/kg day in divided doses every 8 hours.
• Infections of the lower respiratory tract; 50 mg/kg (maximum 3 g) plus probenecid 25 mg /kg (maximum 1 g) in a single dose. Probenecid is not recommended for use in children <2 years of age. Children weighing >45 kg should receive the adult dosing.
• Cases of gonorrhea with a suspected concomitant lesion of syphilis should have darkfield examinations before receiving amoxicillin, and monthly serological tests for a minimum of 4 months.

Meanwhile, If recognized that in the treatment of chronic urinary tract infection, frequent bacteriological and those recommended above should not use. However, higher doses than recommended may need at times. In Addition, persistent infection, therapy may be required for several weeks or longer. It may necessary to continue clinical and bacteriological follow up for severe months after cessation of therapy.

Except for gonorrhea, treatment should continue for a minimum of 48 to 72 hours beyond the time. Therefore, the patients become asymptomatic or evidence of bacterial eradication has obtained. However, It recommended that at least 10 days of treatment for any infection caused by Group A beta-hemolytic streptococcus to prevent the occurrence of acute rheumatic fever or glomerulonephritis.

Wymox (Amoxicillin) Medication Storage Instructions

Firstly, protect the drug from sunlight and heat. And Most importantly always remember to store your medicines out of the reach of children. On the other hand, store the medicine below 30 C temperature and do not let it freeze. Finally, you must first look at the packing of Wymox Medicine for its expiry date and if the product is expired you must not use it to avoid any kind of threat to your life.

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Wymox (Amoxicillin) 250 MG, 500 MG