Atarax Tablets Syrup
Atarax Tablets and syrup contains Hydroxyzine which is a synthetic drug with central nervous system depressant, antispasmodic, antihistaminic and antifibrillatory actions. It administered orally or intramuscularly.
Atarax Tablets Syrup Indications
Hydroxyzine is indicated for the symptomatic relief of anxiety in adults, the symptomatic relief of pruritus and as premedication before surgery.
Atarax Tablets Dosage And Administration
Atarax (Hydroxyzine) should be used at the lowest effective dose and for the shortest possible duration.
Dosage For Adults
In adults and children over 40 KG in weight the maximum daily dose is 100 mg per day.
For Symptomatic Treatment Of Anxiety:
Atarax 50 MG/day in 3 separate administrations of 12.5 - 12.5-25 mg. In more severe cases doses of up to 100MG/day can be used.
For Symptomatic Treatment Of Pruritus:
Starting dose of 25 mg at night increasing as necessary to 25 mg three or four times daily.
For Premedication Before Surgery
50 to 200 mg/day in 1 to 2 administrations. Meanwhile, Single administration 1 hour before surgery which may preceded by 1 administration the night before anaesthesia
Children (Over 12 Months)
On the other hand, For symptomatic treatment of pruritus, from 12 months 1 mg/kg/day up to 2 mg/kg/day in divided doses. Meanwhile, In children upto 40 kg in weight the maximum daily dose is 2 mg/kg/day in divided doses. However, In children over 40 kg in weight, the maximum daily dose 100 mg/day.
For Prededication Before Surgery
Meanwhile, Single administration of 1 mg/kg 1 hour before surgery which may be preceded by 1 mg/kg the night before anaesthesia.
More Useful Drugs Info: Ventolin Tablets, Solution, Syrup Use, Dosage And Side Effects
Atarax Tablets Populations
Atarax For Elderly
Meanwhile, Use of Atarax in the elderly is not recommended. However, In the elderly the maximum daily dose is Atarax 50 MG per day.
Renal Impairment
Most importantly, Atarax Dosage should be reduced in patients which moderate or severe renal function impairment due to decreased excretion of its metabolite cetrizine.
Hepatic Impairment
However, In patients with hepatic dysfunction it is recommended to reduce the daily atarax dose by 33%.
Atarax Contraindications
Meanwhile it Contraindicated in patients with a history of hypersensitivity to hydroxyzine or any of the excipients to cetirizine to other piperazine derivatives to aminophylline or to ethylenediamine. On the other hand, Atarax also contraindicated in pregnancy and lactation, patients with known risk factor to QT interval prolongation including a known cardiovascular disease. Further, Significant electrolytes imbalance (hypokalaemia, hypomagnesaemia) family history of sudden cardiac death, significant bradycardia, concomitant use with drugs known to prolong the QT interval and induce Torsade de Pointes.
Atarax Warnings And Precautions
Hydroxyzine has associated with prolongation for the QT interval on the electrocardiogram. However, during post marketing surveillance there have cases of QT interval prolongation and torsade de pointes in patients taking hydroxyzine. Meanwhile, Most of these patients had other risk factors, electrolyte abnormalities or concomitant treatment that may have contributory. Hydroxyzine should used at the lowest effective dose and for the shortest possible duration. Further, Treatment with hydroxyzine should stopped if signs or symptoms occur that may associated with cardiac arrhythmia. And the patients should seek immediate medical attention. In addition, patients should advised to promptly report any cardiac symptoms. On the other hand, Hydroxyzine should administered cautiously in patients with increased potential for convulsions. Furthermore, In children convulsions have more frequently reported than in adults.
Meanwhile, Atarax also not recommended in elderly patients because of a decrease of hydroxyzine elimination in this population as compared to adults. And greater risk of adverse reaction like, anticholinergic effects. Because of its potential anticholinergic effects, hydroxyzine should used cautiously in patients suffering from glaucoma, bladder outflow obstruction, decreased gastointestinal motility, myasthenia gravis or dementia. On the other hand, Atarax dosage should be reduced in patients with hepatic dysfunction and in patients with moderate or severe renal impairment. However, In the elderly it advised to start with half the recommended dose due to a prolonged action. Most importantly, avoid operation vehicles or machinery and concomitant use of alcohol or CNS depressants.
Atarax Tablets Drug Interactions
Associations contraindicated, Associations requiring precaution of use, Alcohol, CNS depressants, MAOI, Betahistine, anticholinesterase drugs.
Pregnancy And Lactation
Meanwhile, Atarax uses Contraindicated for pregnant women and lactating.
Effects On Ability To Drive And Control Equipment
In addition, Atarax may impair the ability to react and to concentrate. So, Patients should be warned of this possibility and cautioned against driving a car or operating machinery. On the other hand, avoid concurrent use of hydroxyzine with alcohol or tranquilizers.
Atarax Side Effects
Meanwhile, the following Atarax Side Effects reported in placebo controlled clinical trials for hydroxyzine and including 735 subjects exposed to hydroxyzine up to Atarax 50 MG daily.
Very Common: Somnolence
Common: Headache, Dry mouth
Uncommon: Dizziness, Insomnia, Disturbance in attention, Constipation, Nausea, Asthenia
Other Side Effects
- Hypersensitivity
- Anaphylactic shock
- Agitation
- Confusion
- Disorientation
- Hallucination
- Sedation
- Tremor
- Convulsions
- Dyskinesia
- Accommodation disorder
- Vision blurred
- Tachycardia
- QT interval prolongation
- Venticular arrhythmias
- Hypotension
- Bronchospasm
- Vomiting
- Liver function tests abnormal
- Pruritus
- Erythematous rash
- Maculo papular rash
- Urticaria
- Dermatitis
- Angioneurotic oedema
- Hyperhidrosis
- Fixed drug eruption
- Acute generalized exanthematous pustulosis
- Erythema multiforme
- Stevens Johnson Syndrome
- Urinary retention
- Malaise
- Pyrexia
The following Side Effects have also found with Cetirizine the principal metabolite of hydroxyzine
- Thrombocytopenia
- Aggression
- Depression
- Tic
- Dystonia
- Paraesthesia
- Oculogyric crisis
- Diarrhoea
- Dysuria
- Enuresis
- Asthenia
- Oedema
- Weight Increase
Atarax Overdosage Effects
However, Symptoms observed after an important overdose mainly associated with excessive anticholinergic load. However, Central nervous system (CNS) depression or CNS paradoxical stimulation. Meanwhile, The symptoms include nausea, vomiting, tachycardia, pyrexia, somnolence, impaired pupillary reflex, tremor, confusion and hallucination. However, This may followed by depressed level of consciousness, respiratory depression, convulsions, hypotension, or cardiac arrhythmia. Deepening coma and cardiorespiratory collapse may enuse.
Atarax Storage Instructions
Meanwhile, Store the Atarax Tablets below 30 C temperature. On the other hand, Protect from sun light, moisture and excessive heat.
Most importantly, Keep Atarax Syrup below 30 C temperature, Also Protect from heat, moisture and sunlight.
However, always keep your medical products out of the reach of your children because it may risk their life.
More Drug Information: Avsar Tablet 80 MG, 160 MG Use, Dosage Administration And Side Effects
Atarax 25 MG, 10 MG Tablets, Syrup