Atarax Tablets Syrup (Hydroxyzine) Uses Dosage Side Effects Benefits Formula Ingredients Price Details

Atarax Tablets Syrup Uses Dosage Details

Atarax Tablets and syrup contains Hydroxyzine which is a synthetic drug with central nervous system depressant, antispasmodic, antihistaminic and antifibrillatory actions. It administered orally or intramuscularly.

Atarax Tablets Syrup Uses & Indications

Hydroxyzine is indicated for the symptomatic relief of anxiety in adults, the symptomatic relief of pruritus and as premedication before surgery.

Atarax Tablets Dosage And Administration

Atarax (Hydroxyzine) should be used at the lowest effective dose and for the shortest possible duration.

Dosage For Adults

In adults and children over 40 KG in weight the maximum daily dose is 100 mg per day. For Symptomatic Treatment Of Anxiety: 50 MG/day in 3 separate administrations of 12.5 – 12.5-25 mg. In more severe cases doses of up to 100MG/day can be used. For Symptomatic Treatment Of Pruritus: Starting dose of 25 mg at night increasing as necessary to 25 mg three or four times daily. For Premedication Before Surgery 50 to 200 mg/day in 1 to 2 administrations. Meanwhile, Single administration 1 hour before surgery which may preceded by 1 administration the night before anaesthesia

Children (Over 12 Months)

On the other hand, For symptomatic treatment of pruritus, from 12 months 1 mg/kg/day up to 2 mg/kg/day in divided doses. Meanwhile, In children upto 40 kg in weight the maximum daily dose is 2 mg/kg/day in divided doses. However, In children over 40 kg in weight, the maximum daily dose 100 mg/day. For Prededication Before Surgery Meanwhile, Single administration of 1 mg/kg 1 hour before surgery which may be preceded by 1 mg/kg the night before anaesthesia.

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Atarax Tablets Dosage & Administration

Dosage For Elderly

Meanwhile, Use of Atarax in the elderly is not recommended. However, In the elderly the maximum daily dose is 50 MG per day.

Renal Impairment

Most importantly, Atarax Dosage should be reduced in patients which moderate or severe renal function impairment due to decreased excretion of its metabolite cetrizine.

Hepatic Impairment

However, In patients with hepatic dysfunction it is recommended to reduce the daily dose by 33%.

Medicine’s Contraindications Details

Meanwhile it Contraindicated in patients with a history of hypersensitivity to hydroxyzine or any of the excipients to cetirizine to other piperazine derivatives to aminophylline or to ethylenediamine. On the other hand, it also contraindicated in pregnancy and lactation, patients with known risk factor to QT interval prolongation including a known cardiovascular disease. Further, Significant electrolytes imbalance (hypokalaemia, hypomagnesaemia) family history of sudden cardiac death, significant bradycardia, concomitant use with drugs known to prolong the QT interval and induce Torsade de Pointes.

Warnings And Precautions

Hydroxyzine has associated with prolongation for the QT interval on the electrocardiogram. However, during post marketing surveillance there have cases of QT interval prolongation and torsade de pointes in patients taking it. Meanwhile, Most of these patients had other risk factors, electrolyte abnormalities or concomitant treatment that may have contributory. Hydroxyzine should used at the lowest effective dose and for the shortest possible duration. Further, Treatment with it should stopped if signs or symptoms occur that may associated with cardiac arrhythmia. And the patients should seek immediate medical attention. In addition, patients should  advised to promptly report any cardiac symptoms. On the other hand, it should administered cautiously in patients with increased potential for convulsions. Furthermore, In children convulsions have more frequently reported than in adults. Meanwhile, Atarax also not recommended in elderly patients because of a decrease of hydroxyzine elimination in this population as compared to adults. And greater risk of adverse reaction like, anticholinergic effects. Because of its potential anticholinergic effects, it should used cautiously in patients suffering from glaucoma, bladder outflow obstruction, decreased gastointestinal motility, myasthenia gravis or dementia. On the other hand, dosage should be reduced in patients with hepatic dysfunction and in patients with moderate or severe renal impairment. However, In the elderly it  advised to start with half the recommended dose due to a prolonged action. Most importantly, avoid operation vehicles or machinery and concomitant use of alcohol or CNS depressants.

Drug Interactions Details

Associations contraindicated, Associations requiring precaution of use, Alcohol, CNS depressants, MAOI, Betahistine, anticholinesterase drugs.

Pregnancy And Lactation

Meanwhile, the use of this medicine generally Contraindicated for pregnant women and lactating.

Effects On Ability To Drive And Control Equipment

In addition, it may impair the ability to react and to concentrate. So, Patients should be warned of this possibility and cautioned against driving a car or operating machinery. On the other hand, avoid concurrent use of hydroxyzine with alcohol or tranquilizers.

Atarax Side Effects

Meanwhile, the following Atarax Side Effects reported in placebo controlled clinical trials for hydroxyzine and including 735 subjects exposed to the medicine up to 50 MG daily. Very Common:          Somnolence Common:                      Headache, Dry mouth Uncommon:                Dizziness, Insomnia, Disturbance in attention, Constipation, Nausea, Asthenia Other Side Effects

• Hypersensitivity
• Anaphylactic shock
• Agitation
• Confusion
• Disorientation
• Hallucination
• Sedation
• Tremor
• Convulsions
• Dyskinesia
• Accommodation disorder
• Vision blurred
• Tachycardia
• QT interval prolongation
• Venticular arrhythmias
• Hypotension
• Bronchospasm
• Vomiting
• Liver function tests abnormal
• Pruritus
• Erythematous rash
• Maculo papular rash
• Urticaria
• Dermatitis
• Angioneurotic oedema
• Hyperhidrosis
• Fixed drug eruption
• Acute generalized exanthematous pustulosis
• Erythema multiforme
• Stevens Johnson Syndrome
• Urinary retention
• Malaise
• Pyrexia

The following Side Effects have also found with Cetirizine the principal metabolite of this medication

• Thrombocytopenia
• Aggression
• Depression
• Tic
• Dystonia
• Paraesthesia
• Oculogyric crisis
• Diarrhoea
• Dysuria
• Enuresis
• Asthenia
• Oedema
• Weight Increase

Overdosage Effects And Treatment Guide

However, Symptoms observed after an important overdose mainly associated with excessive anticholinergic load. However, Central nervous system (CNS) depression or CNS paradoxical stimulation. Meanwhile, The symptoms include nausea, vomiting, tachycardia, pyrexia, somnolence, impaired pupillary reflex, tremor, confusion and hallucination. However, This may followed by depressed level of consciousness, respiratory depression, convulsions, hypotension, or cardiac arrhythmia. Deepening coma and cardiorespiratory collapse may ensure.

Storage Instructions For This Medicine

Meanwhile, Store the Atarax Tablets below 30 C temperature. On the other hand, Protect from sun light, moisture and excessive heat. Most importantly, Keep Atarax Syrup below 30 C temperature, Also Protect from heat, moisture and sunlight. However, always keep your medical products out of the reach of your children because it may risk their life.

More Drug Information:  

Atarax 25 MG, 10 MG Tablets, Syrup Price In Pakistan (Rs. 109 PKR)

 

Disclaimer

All the details of the medicine provided on this website Pharmacy Online Here are only for informational purposes and there is no intent to substitute for professional medical advice, diagnostic, and treatment purposes. Therefore, always get medical advice from any qualified healthcare provider doctor, or pharmacist for any questions about your medical conditions, symptoms, or disorder. So do not disregard the medical advice of your professional healthcare provider or delay it simply because of the information your read here on this website.  Note:– Always Use Any Type Of Medicines Only Under The Supervision Of A Professional Healthcare Provider, Doctor, Or Pharmacist.