Gravibinan (Progesterone) Injections

Gravibinan Injection contains Estradiol and Progesterone in it. Progesterone Injection is a sex hormone which also called as pregnancy hormone. it mainly acts on uterus in sequence with oestrogen, to prepare the endometrium to receive the fertilized ovum. It used for the treatment of abnormal uterine bleeding, breast and uterine cancers, used for contraception and to treat amenorrhea. While Estradiol a naturally occuring sex hormone which used along with progesterone for contraception, menstrual disorders and for the suppression of certain cancers and also for the prevention of oesteoporosis.

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Gravibinan Injection Qualitative And Quantitative Composition

Gravibinan 1 ML Injection contains <———-> 250 mg Hydroxy Progesterone

Caproate and 5 mg estradiol valerate in oily solution.

 

Gravibinan Injection Therapeutic Indications

These Progesterone Injections IVF use and indicated in Prophylaxis of abortion, threatened abortion. However, the expert physician and doctor may use it for several other disorders.

Gravibinan Injection Dosage And Method Of Administration

Like all oily solutions Gravibinan must be injected intramuscularly. Experience shows that the short-lasting reactions like:

• Urge to cough
• Coughing fits
• Respiratory distress

which occur in rare cases during or immediately after the use of Progesterone Injection of oily solutions can be avoided by injecting the solution extremely slowly.

• Prophylaxis of abortion

There days after the risk in basal body temperature on about the 18th day of the cycle, Gravibinan 1ml is injected intramuscularly. When conception has not occurred, the basal body temperature falls again in the premenstrual period. And there will be normal or, occasionally, rather heavier menstrual bleeding. Sometimes the fall in temperature may delayed for 2-3 day.

Where failure of the menstrual bleeding and continued elevation of the basal body temperature indicate an early pregnancy. An intramuscular injection of Progesterone Injection 1ml IVF given immediately. The hormone dose doubled one week later i.e. from the beginning of the sixth week of pregnancy on (the pregnancy is reckoned as starting on the first day of the of the last menstruation): Gravibian 2ML is administered intramuscularly every week during the first months of pregnancy, in isolated cases even longer.

The diagnosis of pregnancy should be confirmed by an immunological pregnancy test about two weeks after the failure of the expected menstruation. Therapy also of an advantage when a patient with a predisposition to habitual abortion does not come for treatment until after the start of the fresh pregnancy. Progesterone Injection 2ML IVF is injected intramuscularly immediately. Followed by 2 ml Gravibinan intramuscularly every week during the first months of pregnancy. In isolated cases, it used even longer.

Threatened Abortion

To institute treatment 2 ml Progesterone injected intramuscularly twice weekly until the bleeding stops. Bed-rest urgently advised during this time. When the bleeding ceases. 2 ml Gravibinan gave intramuscularly weekly for some weeks until the patient remains free from complaints and bleeding despite mobilization. Whether Progesterone therapy is to be continued as a prophylactical measure must be decided individually.

Gravibinan Injection Contraindications

Firstly, the Progesterone Injections contraindicated in a history of herpes of pregnancy, thromboembolic processes.

Gravibinan Progesterone Injection Special Warnings And Precautions

According to the present state of scientific knowledge, medicinal therapy should be given in early pregnancy only if it is absolutely essential. This is also valid for the use of hormone preparations such as Progesterone for the maintenance of pregnancy. Consequently, Gravilbinan should only be prescribed if there is an urgent desire for children-primarily in the presence of corpusluteum insufficiency or a case history of abortion.

Because Gravibinan places the uterus at rest, it is possible for an already dead embryo to be retained. In the case of protracted therapy, it is, therefore, necessary to check the continued existence of pregnancy by means of appropriate examinations and immunological tests.

It has concluded from epidemiological surveys that the use of oral estrogen/progestogen containing ovulation inhibitors attended by an increased incidence of thromboembolic diseases. Although no such associations suspected for injectable steroidal preparations of similar composition. One should keep the possibility of an increased thromboembolic risk in mind. Particularly where there a history of thromboembolic changes or sickle-cell anemia.

Gravibinan Progesterone Injection Possible Teratogenic Side Effects

Like all the other medicines Gravibinan Progesterone Injections IVF minor Side Effects in some patients. A possible association between the administration of female sex hormones in early pregnancy and the occurrence of malformations has the present state of scientific knowledge. The assumption that there may a causal association can regard as unfounded. However, it must clearly understood, that no drug- including sex hormones-can claimed with absolute certainty to free from teratogenic effects.

Gravibinan Injection Dug Interactions

The requirement for oral anti-diabetics or insulin can change.

Gravibinan Progesterone Injection IVF Use During Pregnancy And Lactation

In view of the therapeutic indications, a reference to the Gravibinan Progesterone Injection IVF use during pregnancy and lactation is irrelevant. So most importantly, you must consult your doctor or physician if you planned to get pregnant. Or already have a pregnancy before using progesterone injections.

Gravibinan Progesterone IVF Injection Side Effects

Strict medical supervision is necessary if the patient suffers from diabetes. 8 to 14 days after unsuccessful treatment of threatened abortion and subsequent curettage withdrawal bleeding may occur in isolated cases. Owing to the continuing Gravibian The Progesterone IVF Injection Side Effects which subsides only gradually. However, no further measures are necessary.

Gravibinan Overdose

Acute toxicity studies showed that Gravibinan is to be classified as practically non-toxic. No risk of toxicity is to be expected even after inadvertent single administration of a multiple of the Gravibinan dose required for therapy.

Gravibinan Pharmacological Properties

• Pharmacodynamic Properties

The prophylactic use of Gravibinan in habitual abortion or uterine hypoplasia improves nidation conditions for a fertilized ovum by making good the deficit of hormones. Growth of the uterus stimulated and a state of quiescence subsequently induced. In the therapy of threatened abortion Gravibinan has the effect of placing the uterus in a state of quiescence. The hormone combination also increases the metabolic capacity of the placenta. Thus promoting further development of the conceptus.

Gravibian Storage Instructions

Store the injection below 30 C temperature. Protect from heat and sunlight. Always keep all the medicine out of the reach of the children.

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