Maxolon Tablets, Syrup, Injection

Maxolon Tablets, Injection, Syrup is the formulation of a useful drug named Metoclopramide HCL. Which is antiemetic with dopamine antagonist action in brain and peripheral effect on gastro intestinal tract. Where it stimulates motility to improve gastric emptying and intestinal transit. Meanwhile, Metoclopramide HCL used to treat nausea and vomiting of most causes and as an adjunct to X-ray examination of the gut. It used both orally and parentrally.

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Maxolon Tablets, Syrup, Injection Pharmacology

The action of Maxolon Tablets, Syrup, Injection closely associated with parasympathetic nervous control of the upper gastrointestinal tracts. Where Maxolon has the effects to encaurage normal peristaltic action. This provides approach to the treatment of those conditions where disturbed gastrointestinal motility a common underlying factor.

Maxolon Indications

Maxolon Uses In Adults (20 Years And Over)

Digestive Symptoms Includes:

• Dyspepsia
• Heatburn
• Flatulence
• Sickness
• Regurgitation Of Bile
• Pain

Maxolon Use In Digestive Disorder Conditions Like:

• Peptic Ulcer
• Duodenitis
• Reflux Oesophagitis
• Hiatus Hernia
• Gastritis
• Cholelithlasis And Post Cholecystectomy Dyspepsia
• Post Operative Gastric Hypotonia
• Post Vagotomy Syndrome

Maxolon promotes normal gastric emptying and restores motility in vagotomised patients and when post operative symptoms suggest gastro duodenal dysfunction.

Nausesa And Vomiting Associated With:

• Gastro Intestinal Disorders
• Intolerance to essential drugs including digitalis antibacterial and cytotoxic drugs Congestive heart failure
• Deep X-ray or cobalt therapy
• Post anaesthetic vomiting

Diagnostic Procedures

Radiology: Maxolon speeds up the passage of barium meal by decreasing gastric emptying time, co-ordinating

Duodenal Intubation Peristalsis and dilating the duodenal bulb, Mazolon also facilitates duodenal intubation procedures.

Migraine: Maxolon medicine relieves symptoms of nausea and vomiting and overcomes gastric stasis associated with migraine. This improvement in gastric emptying assists the absorption of concurrently administered oral anti migraine therapy like. paracetamol which may otherwise be impaired in such patients.

The Maxolon Use in patients under 20 years should be restricted to the following:

• Severe intractable vomiting of known cause.
• Also vomiting which associated with radiotherapy and intolerance to cytotoxic drug.
• As an aid to gastro intestinal intubation and diagnostic radiology.
• As part of the premedication before surgical procedures.

Maxolon Tablets Dosage And Administration

The Maxolon Tablets, Syrup, Injection Dosage recommendation given below should be strictly adhered to if side effects of the dystonictype are to be avoid. It should be noted that total daily Maxolon Dosage especially for children and young adults should not normally exceed Maxolon 0.5 mg/kg body weight.

Maxolon Oral Dosage

Adults 15 years and over: with weight of 60 kg or more Maxolon 10 mg dose used three times daily.

Adults 15 years and over: less than 60 kg body weight Maxolon 5 mg three times daily.

Maxolon Injection, Tablets, Syrup should only be used after careful examination to avoid masking an underlying disorder e.g. Cerebal irritation in the treatment of young adults. On the other hand, children attention should given primarily to body weight and treatment should commence at the lower Maxolon dosage where stated.

Maxolon Dose For Children

• 9 - 14 years 30 kg and over 5 mg three times daily
• 5 - 9 years 20 - 29 kg 2.5 mg three times daily
• 3 - 5 years 15 - 19 kg 2 mg two to three times daily
• 1 - 3 years 10 - 14 kg 1 mg two to three times daily
• under 1 year up to 10 kg 1 mg twice daily

Furthermore, A liquid presentation should used in the younger age groups as the facilitates accurate dosage and administration.

Maxolon I.M. or I.V Injection Dosage

Maxolon Injection may be administered at the dosage stated above either intramuscularly or by slow intravenous Maxolon injection (1 - 2 minutes)

Radiological And Intibational Indication

A single dose of Maxolon Medicine may be given 5 - 10 minutes before examinations. Subject to body weight consideration the following Maxolon dosage recommended.

Adults 20 Years And Over 10 - 20 mg

Young Adults 15 - 19 Years 10 mg

Children 9 - 14 Years 5 mg

5 - 9 Years 2.5 mg

3 - 5 Years 2 mg

Under 3 Years 1 mg

Indications For Maxolon High Dose Intravenous Therapy

Treatment of nausea and vomiting associated with intolerance to cytotoxic drugs.

Dosage And Administration: 2 mg/kg body weight by Maxolon I.V. infusion. It recommended that each dose should added to at least 50 mg of an appropriate diluent and infused over at least 15 minutes. the initial dose should given prior to commencement of cytotoxic chemotherapy. However, Dosage may repeated 2 hourly up to a maximum of Maxolon10 mg/kg body weight in any 24 hour period.

The Cytotoxic Agent Should Administered As a Separate Infusion

Stability In Intravenous Solution

Intravenous solution should prepared as near as possible to the time of use. Maxolon Medicine shown to stable in the solutions listed below for at least 24 hours at the temperature of 25 C.

• Sodium Chloride Intravenous Infusion BP 0.9% w/v
• Glucose Intravenous Infusion BP 5% w/v
• Sodium Chloride and Glucose Intravenous Infusion BP sod, chlor 0.18% w/v, glucose 4% w/v
• Compound Sodium Lactate Intravenous Infusion BP, and ringer lactate solution or Hartmann’s solution

Maxolon Drug Special Precautions

If vomiting persists the patient should re-assessed to exclude the possibility of an underlying disorder for example cerebral irritation.

After the operations Like pyloroplasty or gut anastomosis Maxolon Drug therapy should withheld for 3 or 4 days as vigorous muscular contractions may not help healing

Since extra-pyramidal symptoms may occur both Maxolon and neuroleptics such as phenothaiazines, particular care should exercised in the event of these drugs being prescribed concurrently

Consequently, The action of Maxolon on the gastro-intestinal tract antagonised by anticholinergics. The absorption on any concurrently administered oral medication may modified by the effect of Maxolon on gastric motility.

Maxolon In Pregnancy

About the use of Maxolon In Pregnancy the Animal test in several mammalian species and clinical experience have not indicated a teratogenic effect. nevertheless. Maxolon should be used when they are compelling reasons and and it not advised during the first trimestar.

Use In Abnormal Renal Or Liver Function

Meanwhile, In patients with clinically significant degrees of renal or hepatic, impairment oral, I.V or I.M therapy should be initiated at half the usual doze. subsequent usage will depend on the individual clinical response.

Maxolon Use For Elderly patients

Furthermore, to avoid adverse reactions adhere strictly to dosage recommendations where prolonged therapy considered necessary should regularly reviewed.

Maxolon Side Effects

Many kind of extra-pyramidal Maxolon Side Effects usually have been reported. The incidence of these reactions, particularly in children and young adults increased if daily Maxolon dosages higher then 0.5 mg/kg body weight administered. Dystonic reactions include:

• Spasm of the facial muscles
• Trismus
• Rhythmic profusion of the tongue
• Bulbar type of speech
• Spasm of extra-ocular muscles
• Oculogyric crises
• Unnatural positioning of the head and shoulders
• Opisthotonos

Furthermore, There may be a generalized increase in the muscle tone.

However, The majority of Maxolon Side Effects occur within thirty six hours of starting treatment and the effects usually disappear within twenty four hours of withdrawal of the maxolon drug. So, treatment of a dystonic reaction required an anticholinergic anti-parkinson drugs of benzodiazepine may used.

Tradive dyskinesia has reported during prolonged treatment in a small number of mainly elderly patients. So, Patients on prolonged treatment should regularly reviewed. Furthermore, Metoclopramide may induce an acute hypertensive reports in patients with phaeochromocytoma.

Raised serum prolacting levels have observed during Metoclopramide therapy. Meanwhile, this effect is similar to that noted with many other compounds. Therefore, when given at maxolon high dose in connection with cancer chemotherapy. The drug Maxolon has well tolerated with few side effects, the most common being mild sedations. In conclusion, you must contact your doctor or pharmacist or got to nearly hospital if any side effects shown.

Maxolon Overdose

Maxolon Overdose should be treated by gastric lavage with appropriate supportive measures. Most importantly, immediately contact your doctor or go to hospital.

Maxolon Drug Storage Instrucions

Firstly, Store Maxolon Drug below 25 C and protect the medicine from heat and sunlight. However, If Maxolon ampoules inadvertently exposed to light, any that show a yellow discolouration must be discarded. On the other hand, most importantly, protect your children by keeping your medical products out of the reach of your children.

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Maxolon Syrup, Injection, Tablets