New Risek Capsules Tablets Sachet 20MG 40MG Omeprazole Uses Dosage Side Effects Benefits Price Details

What Is Risek Omeprazole Capsules Tablets Sachets? What Are Its Uses Dosage Side Effects?

Risek Capsules (Omeprazole) 20mg, 40mg is a substituted benzimidazole which is a proton pump inhibitor that inhibits gastric acid secretion. Chemically Omeprazole is 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl)methyl] sulfinyl]-1Hbenzimidazole. Normally its available in tablet, capsule and sachets form widely all around the world. It proves effective in the relief of symptoms related to gastrointestinal and digestive system disorders.

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Omeprazole reduces gastric acid secretion through a unique mechanism of action. And Omeprazole belongs to a new class of anti secretory compounds. The substituted benzimidazoles that do not exhibit anti-cholinergic or histamine antagonistic properties. It inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine  triphosphates (H+/K+ ATPase). The proton pump of gastric parietal cell. This effect is dose related and leads to inhibition of both stimulated acid secretion irrespective of the stimulus.

Uses In Urdu Hindi

Risek Tablets Capsules Sachets Special Populations

For Pediatric

Available data from children (1 year and older) suggest that the pharmacokinetics  within the recommended Risek Dosage are similar to those reported in adults. At steady state, lower plasma levels of Omeprazole seen in some children. In children younger than 6 months, clearance of this medicine is low due to low capacity to metabolize it

 For Geriatric

The bio-availability of Omeprazole Dosage for Adults patients may be increased. The metabolism rate of the medication is somewhat reduced in patients in between ages 75 to 79 years.

For Renal Insufficiency

The systemic bio-availability of this medication is not significantly altered in patients with reduced renal function. Therefore (Risek) dosage adjustment not required.

For Hepatic Insufficiency

The area under the plasma concentration time curve is increased in patients with impaired liver function. But no tendency to accumulation of Omeprazole has found.

Risek Insta (Omeprazole) Tablets Sachets Capsules Uses & Indications

Risk (Omeprazole) Capsules 20mg, 40mg used for in adults for the treatment of:

• Gastro Esophageal Reflux Disease
• Treatment of erosive reflux esphagitis.
• Long term management of patients with healed esophagitis to prevent relapse.
• Symptomatic treatment of gastroesophageal reflux disease
• Gastric and duodenal ulcer
• Treatment and prophylaxis of NSAID associated ulceration
• Eradication of Helicobacter pylori infection associated with peptic ulcer disease.
• Zollinger Ellison syndrome
• Dyspepsia
• Prophylaxis of acid aspiration.

Risek 20MG, 40MG Tablets Dosage And Administration

Risek capsules given both mouth which should be swallowed whole and not crushed or chewed. For Symptomatic Gastro Esophageal Reflux Disease Without Esophagitis: The recommended adult oral Dosage is Risek 20mg Tablets daily for up to 4 weeks. For Erosive Esophagitis: The recommended adult oral dose for the treatment of patients with erosive esophagitis and accompanying symptoms due to GERD Risek 20mg Tablets daily for 4 to 8 weeks. For Maintenance of Healing of Erosive Esophagitis: The recommended adult oral  dose is  20mg daily.  Dosage For Children in GERD: In children Omeprazole Dosage in the ranges 0.7 to 1.4 mg per kg body weight daily up to a maximum daily dose of  40mg have been given for 4 to 12 weeks. For Gastric And Duodenal Ulcer: A single daily Omeprazole Dosage of 20 mg by mouth or Risek 40 mg in severe cased is given. Treatment is continued for 4 weeks for duodenal ulcer and 8 weeks for gastric ulcer. Where appropriate a dose of 10mg to 20mg once daily may be given for maintenance.

Prevention Of Relapse Of Gastric Ulcer:

For the prevention of relapse in patients with poorly responsive gastric ulcer the recommended Dose is Risek 20 mg once daily. However, If needed the dose can be increased to  40 mg once daily. NSAID Associated Ulceration: However, Doses of Omeprazole 20 mg daily used in the treatment of NSAID associated ulceration. Therefore, A dose of 20 mg daily may also used for prophylaxis in patients with a previous history of gastroduodenal lesions who require continued NSAID treatment. Helicobacter Pylori Eradication For the eradication of Helicobacter pylori in peptic ulceration 40mg daily may combined with antibacterial in dual therapy or tab or sachet 20mg twice daily may combined with antibacterial in triple therapy. Therefore, it alone may continued for a further 2 to 8 weeks. Zollinger Ellison Sydrome. Firstly, The initial dose is Risek (Omeprazole) 60mg by mouth once daily adjusted as required. Meanwhile, The majority f patients are effectively controlled by doses in the range 20mg to 120mg daily. But doses up to 120mg three times daily have been used. Consequently, the daily doses above 80mg should be administered in divided doses. Dyspepsia: On the other hand, For the relief of acid related dyspepsia Omeprazole given in usual dose of Risek 10mg or 20mg daily by mouth for 2 to 4 weeks. Prophylaxis Of Acid Aspiration: However, it is also used for the prophylaxis of acid aspiration during general anesthesia in a dose of 40mg the evening before surgery. And a further 40mg two to six hours before the procedure. Dosage For Hepatic Impaired Patients Meanwhile, A maximum daily dose of 20mg is recommended for patients with impaired hepatic function.

Risek Insta 20 MG 40 MG (Omeprazole) Side Effects

Generally, Omeprazole Insta Risek Tablets Capsules Sachets is well tolerated and did not shown any of the side effects. But,  Side Effects have generally been mild and reversible which shown only in some patients. Common Side Effects Central And Peripheral Nervous System

• Headache

Gastrointestinal Side Effects

• Diarrhea
• Constipation
• Abdominal Pain
• Nausea
• Vomiting
• Flatulence

Uncommon Side Effects

Central And Peripheral Nervous System

• Dizziness
• Paranesthesia
• Somnolence
• Insomnia
• Vertigo

Hepatic

• Increased liver enzymes

Skin

• Rash
• Pruritic
• Urticaria
• Malaise

Rare Omeprazole Side Effects

Central And Peripheral Nervous System:

• Reversible Mental Confusion
• Agitation
• Aggression
• Depression
• Hallucinations
• Predominantly in Severely ill Patients

Endocrine

• Gynecomastia

Gastroinstestinal

• Dry Mouth
• Stomatitis
• Gastroinstestinal Candidiasis

Hematological

• Leukopenia
• Thrombocytopenia
• Agranulocytosis
• Pancytopenia

Furthermore, the Gastro duodenal carcinoids have been reported in patients with Zollinger Ellison syndrome on long term treatment with omeprazole.

Contraindications Details

Most importantly, it is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles. On the other had, it must not used concomitantly with nelfinavir.

General Precautions & Warnings

• When gastric ulcer is suspected the possibility of malignancy should be excluded as treatment may alleviate symptoms and delay diagnosis.
• Meanwhile, prior to initiation of dual or triple therapy the physician should consider the patient with known hypersensitivity reactions to penicillin, macrolides and other antibiotics.
• The product as all acid blocking medicines may reduce the absorption of Vitamin B12 due to hypo or achlorhydria. Therefore, this considered in patients with reduce body stores or risk factors for reduced Vitamin B12 absorption on long term therapy.
• Consequently, severe hypomagnesemia reported in patients treated with proton pump inhibitors like this for  at least three months and in most cases for a year.
• Consequently, the proton pump inhibitors especially if used in high doses and over long durations of greater than one year. On the other hand, it may modestly increase the risk of hip, wrist and spine fracture, predominantly in the elderly or in presence of other recognized risk factors.

Hepatic Impairment Firstly, the consideration should given to reducing the dose of the tab or syp in patients with impaired hepatic function as bioavailability and half life can increase. Use In Pregnancy However, There are not enough or well controlled studies about Omeprazole in Pregnancy for women. Therefore, it should used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nursing Mothers Meanwhile, Known that the medication excreted in human milk. Because many products are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from this product. Most importantly, A decision should made to discontinue nursing or to discontinue the product. Therefore, taking into importance of the medical product to the mother.

Drug Interactions Details

• In common with the use of other inhibitors of acid secretion or antacids the absorption of ketoconazole. And itraconazole can decrease during treatment with this medication due to decreased intragastrical acidity during treatment with risek.
• It metabolized by CPY2C19. Thus when syp or cap combined with drugs metabolized by CPY2C19 such as diazepam, citalopram, imipramine, clomipramine, phenytoin etc. Meanwhile, the plasma concentrations of these drugs may increased and a dose reduction could needed.

Atazanavir

The plasma levels of atazanavir decreased in case of co-administration with it. Therefore concomitant administration of omeprazole with atazanavir not recommended.

Digoxin

Consequently, the concomitant treatment with its 20mg daily and digoxin increased the bio-availability of digoxin by 10%. Caution should exercised when the tab given at high doses in elderly patients. On the other hand, Therapeutic drug monitoring of digoxin should reinforced.

Clopidogrel

On the other hand, Omeprazole a CYP2C19 inhibitor. However, when starting or ending treatment with it the potential for interactions with products metabolized through CYP2C19 should considered. Meanwhile, An interaction observed between these. Therefore, As precaution concomitant use of this and clopidogrel should discouraged.

Other Active Substances

However, the absorption of parconazole, erlotinib, ketoconazole and itraconazole significantly reduced and thus clinical efficacy may impaired. Meanwhile For Parconazole and erlotinib concomitant use should avoided.

Saquinavir

Generally, Concomitant administration of this product with saquinavir resulted in increased plasma levels up to approximately 70% for saquinavir associated with good tolerability in HIV-infected patients.

Tacrolimus

However, Concomitant administration of the medicine has reported to increase the serum levels of tacrolimus. Therefore, A reinforced monitoring of tacrolimus concentrations as well as renal function should perform. So, dosage of tacrolimus must first adjusted if needed. Methotrexate when given together with proton pump inhibitors, methotrexate levels have reported to increase in some patients. However, In high dose methotrexate administration a temporary withdrawal of the medication may need to considered.

Risek Capsules Tablets Sachets (Omeprazole) Overdose

Symptoms

• Nausea
• Vomiting
• Dizziness
• Abdominal Pain
• Diarrhea
• Headache
• Apathy
• Depression
• Confusion

Treatment After Overdose Meanwhile, No specific antidote for omeprazole over dosage known. Furthermore, It extensively protein bound and therefore not readily dialyzable. However, In the event of over dosage treatment should symptomatic and supportive.

Storage Instructions

Most importantly keep all the medical products like tablets, injection, syrups, creams out of the reach of your children. On the other hand, Store Risek Tablets below 30 C and also protect from sunlight and moisture. Meanwhile also protect from direct sun light and heat. Lastly you must check the packing of the medicine for the expiry date which always printed on every pack of each medicine. If the product expired you must not use the medicine to avoid any king of mishaps.

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Risek Insta (Omeprazole) Capsules Tablets Sachets 20MG, 40MG Price Details

• Price In Pakistan: Rs. 240 PKR
• Price In India: 199 INR
• Price In USA: $ 6 USD

 

Disclaimer

All the details of the medicine provided on this website Pharmacy Online Here are only for informational purposes and there is no intent to substitute for professional medical advice, diagnostic, and treatment purposes. Therefore, always get medical advice from any qualified healthcare provider doctor, or pharmacist for any questions about your medical conditions, symptoms, or disorder. So do not disregard the medical advice of your professional healthcare provider or delay it simply because of the information your read here on this website.  Note:– Always Use Any Type Of Medicines Only Under The Supervision Of A Professional Healthcare Provider, Doctor, Or Pharmacist.