A Comprehensive Guide Of Voltral Tablets Uses Dosage Side Effects Benefits Price

What Are Voltral Tablets Uses Side Effects?

Voltral Tablets contain Diclo fenac Sodium in it. Diclofenic Sodium is a NSAID a simple phenylacetic acid derivative. On the other hand, It resembles both flurbi pro fen and mec lofena mate. It reduces fever and inflammation and relieves pain. Most importantly Novartis Pharma Pvt Ltd Intl are the manufacturer of this product. On the other hand they also marketed this product world wide in international markets too.

More Pharma Products:  Losec Tablets 10MG 20MG 40MG Uses Dosage Side Effects Price

What Are Voltral Tablets Uses & Indications?

Voltral tablets used for the treatment of:

• Inflammatory and degenerative forms of rheumatism: rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, osteoarthritis. Further spondylarthritis, painful syndromes of the vertebral column, and non-articular rheumatism.
• Acute attacks of gout.
• Post-traumatic and postoperative pain, inflammation, and swelling, e.g. following dental or orthopedic surgery.
• Painful and/or inflammatory conditions in gynecology e.g. primary dysmenorrhea or adnexitis.
• Migraine attacks.
• As an adjuvant in severe painful inflammatory infections of the ear, nose, or throat. e.g. pharyngotonsillitis, otitis. On the other hand In keeping with general therapeutic principles, the underlying disease should treated with basic therapy, as appropriate. Fever alone is not an indication.

How Much Voltral Tablets Dosage Used?

Most importantly, as a general advice, the dosage of Voltral should be individually adjusted based on the patient’s condition, and only a qualified doctor or pharmacist should do so. However, by utilizing the lowest effective dosage for the shortest time period required to treat symptoms, side effects may be reduced.

• Dose For Adults

But the first daily dose of voltaren is often between 100 and 150 mg. 75 to 100 mg per day is often enough for long-term treatment for milder situations. However, the complete daily dosage should often be split into 2 to 3 doses. Further Treatment with tablets during the day may be augmented with the use of a suppository at evening (up to a total maximum daily dosage of 150 mg) to reduce nocturnal discomfort and morning stiffness.

Meanwhile In primary dysmenorrhea, the daily dose should individually adjusted and generally 50 to 150 mg. A dose of 50 to 100 mg given initially. However, if needs to increased over the course of several menstrual cycles up to a maximum of 200 mg/day. On the other hand Treatment should started on appearance of the first symptoms and depending on the symptomatology, continued for a few days.

Meanwhile Treatment of migraine attacks with the medicine suppositories should started with a dose of 100 mg at the first signs of an impending attack. In addition suppositories up to 100 mg may  taken same day if required. Further Should the patients require  further therapy on the following days, the maximum daily dose should limited to 150 mg in divided doses.

Special Populations Insturctions

• Pediatric Patients  (below 18 years of age)

Adolescents and children must divide their daily intake of 0.5 to 2 mg/kg body weight into two or three different doses starting at the age of one. In the meanwhile, it depends on how severe the illness is. However, the dosage may be increased to a maximum of mg/kg daily given in split doses for the treatment of juvenile rheumatoid arthritis. The most essential thing is to not go over the 150 mg daily limit.

On the other hand Voltral 12.5 mg or 25 mg suppositories recommended for use in children and adolescents below 14 years of age. Because of their dosage strength Voltral 50 mg suppositories recommended for use in children and adolescents blow 14 years of age. However Voltral 100 mg suppositories must not use in children and adolescents as it is not suitable for children and adolescents.

• Geriatric Patients (aged 65 years or above )

No adjustment of the starting dose  generally required for old patients. However, caution indicated on basic medical grounds especially for frail high age patients or those with a low body wight.

• Established Cardiovascular Disease Or Significant Cardiovascular Risk Factors

Treatment with Voltral generally not recommended in patients with established cardiovascular disease or uncontrolled hypertension. But If needed, patients with established cardiovascular disease, uncontrolled hypertension. Or significant risk factors for cardiovascular disease should treated with this medication only after careful consideration.

• Renal Impairment

Patients with renal failure (GFR15 mL/min/1.73 m2) should not use voltral. On the other hand, no particular research on individuals with renal impairment has been done. As a result, no suggestions for a particular dosage change can be provided. However, individuals with renal impairment should be treated with care while using this medicine.

• Hepatic Impairment

Votral contraindicated in patients with hepatic failure. However No specific studies have carried out in patients with hepatic impairment. So therefore, no specific dose adjustment recommendations can made. Meanwhile Caution is advised when administering it to patients with mild to moderate hepatic impairment.

Method Of Administration To Use This Medicine

The suppositories should inserted well into the rectum. On the other hand recommended to take the suppositories after passing stools.

Not to be taken by mouth, as for rectal use only.

What Are The Contraindications To Use Voltral SR?

• Known hypersensitivity to the active substance or to any of the other excipients.
• Active gastric or intestinal ulcer, bleeding or perforation.
• Last trimester of pregnancy.
• Hepatic failure.
• Renal failure.
• Like other non-steroidal anti-inflammatory products (NSAIDs). Furthermore, Voltral Medicine also contraindicated in patients whom the use of acetylsalicylic acid. Or other NSAIDs can precipitate asthma, angiodema, urticaria, or acute rhinitis (i.e. NSAID-induced cross-reactivity reactions).

What Type Of Voltral Tablets Side Effects Appear?

Voltaren Tablets Side Effects from clinical trials and/or spontaneous or literature cases are listed by MedDRA system class. Within each system organ class, the side effects are ranked by frequency, with the most frequent reactions first. Within each frequency groups the adverse reactions shown in order of decreasing seriousness. In addition, the corresponding frequency category for each adverse  reaction is based on the following convention (CIOMS 111):

• Very common (>/- 1/10)
• Common (>/- 1/100 to <1/10)
• Uncommon (>/- 1/1,000 to < 1/100)
• Rare (>/- 1/10,000 to < 1/1,000)
• Very rare (< 1/10,000).

The following Voltaren side effects include those reported with suppositories and/or other pharmaceutical forms of diclofenac. with either short-term or long-term use.

• Blood And Lymphatic System Disorders

Very Rare    :      Thrombocytopenia, leukopenia, anemia(including hemolytic and aplastic), agranulocytosis.

• Immune System disorders

Rare              :        Hypersensitivity, anaphylactic and anaphylactoid reactions (including hypotension and shock).

Very Rare  :        Angioedema (including face edema).

• Psychiatric Disorders

Very Rare  :        Disorientation, Depression, insomnia, nightmare, irritability, psychotic disorder.

• Nervous System Disorders

Common    :       Headache, dizziness.

Rare              :       Somnolence.

Very Rare   :      Paresthesia, memory impairment, convulsion, anxiety, tremor, aseptic meningitis, cerebrovascular accident.

• Eye Disorders

Very Rare   :       Visual Impairment, blurred vision, diplopia.

• Ear And Labyrinth Disorders

Common     :       Vertigo.

Very Rare    :      Tinnitus, impaired hearing.

• Cardiac Disorders

Uncommon  :    Myocardial infarction, cardiac failure, palpitations, chest pain.

• Vascular Disorders

Very Rare      :    hypertension, vasculitis.

• Respiratory, Thoracic And Mediastinal Disorders

Rare                  :      Asthma (including dyspnea).

Very Rare      :      Pneumonitis

• Gastro Intestinal Disorders

Common     :      Nausea, vomiting, Diarrhea, dyspepsia, abdominal pain, flatulence, decreased appetite

Rare               :      Gastritis, gastrointestinal hemorrhage, hematemesis, hemorrhagic diarrhea, melena, gastrointestinal ulcer, proctitis.

Very Rare   :       Colitis, constipation, stomatitis, glossitis, esophageal disorder, intestinal diaphragm disease, pancreatitis, hemorrhoids.

• Hepatobiliary Disorders

Common    :        Transaminases increased

Rare              :         Hepatitis, jaundice, liver disorder

Very Rare  :          Fulminant hepatitis, hepatic necrosis, hepatic failure

• Skin And Subcutaneous Tissue Disorders

Common    :      Rash

Rare             :       Urticaria

Very Rare   :       Bullous dermatitis, eczema, erythema, erythema multiforme, Stevens Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, alopecia, photosensitivity reaction, purpura, henoch schoenlein purpura, pruritus.

• Renal And Urinary Disorders

Very Rare       :       Acute kidney injury, hematuria, proteinuria, nephrotic syndrome, tubulointerstitial nephritis, renal papillary necrosis

• General Disorders And Administration Site Condition

Common         :        Application site irritation

Rare                   :        Edema

Description Of Selected Adverse Reactions

• Arteriothrombotic Events

Meta-analysis and pharmacoepidemological data point towards a small increased risk of arteriothrombotic event associated with the use of Diclofenac, particularly at a high dose (150 mg daily ) during long-term treatment.

• Visual Effects

Visual disturbances such diplopia, blurred vision, or visual impairment seem to be NSAID class effects and are often reversible upon stopping use. Inhibition of prostaglandin production is a plausible explanation for the visual abnormalities. And several related substances that influence how the retinal blood flow is regulated, potentially altering vision. However An ophthalmological examination may be undertaken if such symptoms arise while taking diclofenac in order to rule out other possible reasons.

What Are The Drug Interactions To Avoid When Used Voltral Tablets?

The following Interactions observed when the treatment with this medicine is needed

• CYP2C9 Inhitors:

Caution is recommended when co-prescribing diclofence with CYP2C9 inhibitors (such as voriconazole), which could result result in a sinificant increase in peak plasma concentrations and exposure to diclofenac.

• Lithium:

If used concoitantly, diclofenac may raise plasma concentrations of lithium. Monitoring of the serum lithium levels is recommended.

• Dioxin:

If used concoitantly, diclofenac may raise plasma concentrations of lithium.Monitoring of the serum digoxin level is recommended.

• Diuretics And Anti Hypertensive Agents;

Like other NSAIDs, diclofence may have a reduced antihypertensive impact when used concurrently with diuretics or other hypertension medications (such as beta-blockers or ACE inhibitors). Therefore, it is important to give the combination of these medications with prudence, and patients—especially those who are older—should have their blood pressure checked on a regular basis.

Patients need to drink enough water, and after that, attention should be paid, especially to making sure they are properly hypnotized. Additionally, after the start of concurrent treatment, renal function must be monitored. Or at regular intervals going forward, especially with ACE inhibitors and diuretics owing to the elevated risk of nephrotoxicity.

• Ciclosporin And Tacrolimus;

Diclofenac, like other NSAIDs, may increase the nephrotoxicity of ciclosporin and tacrolimus due to the effect on renal prostaglandin. Terefore, it should be given at doses lower than those that would be used in patients not receiving ciclosporin or tacrollimus.

• Products known To Cause Hyperkalemia:

Concomitant treatment with with potassium-spar-increased serum potassium levels, which should therefor be monitored frequently.

• Quinolone Antibacterials:

There have been isolated reported of convulsions which may have been due to conconitant use of quinolones and NSAIDs.

Is It Safe To Use Voltral Use In Pregnancy And Breast Feeding?

• Women Of Child-Bearing Potential

There are no data to suggest any recommendations for women of child bearing potential.

• Voltral Tab Use In Pregnancy

There are insufficient data on the use of Voltaren in pregnancy. However some epidemiological studies an increased risk of miscarriage after use of a prostaglandin sythesis inhibitor in early pregnancy. However the overall data inconclusive. Meanwhile the capsules should not used during the first two trimeters of pregnancy unless the expected benefits to the mother outweight the risks to the fetus. As with other NSAIDs use of Diclofenac during the third trimester for pregnancy contraindicated owing to the possibility of uterine inertia. Or in Fetal renal impairment with subsequent oligohydramnios and premature closure of the ductus arteriosus.

• Use During Breast Feeding

Breast-feeding Like other NSAIDs , diclofenac passes into breast milk in small amounts. Therefore, it  should not administration during breast feeding in order to avoid undesirable effects in the infant.

• Fertility

As with other NSAIDs, the use of the capsules may impair female fertility and  not recommended in women attempting to conceive. In women have difficulties conceiving. Or who undergoing investigation of infertility, withdrawal of the medicine must be stopped.

What Are The Overdosage Symptoms & Treatment?

• Symptoms

However no clinical data yet available for Voltral (Diclofenac) tab overdosage symptoms. Meanwhile overdosage can cause symptoms such Like.

• Vomiting
• Gastrointesinal Hemorrhage
• Diarrhea
• Diziness
• Tinnitus
• Convulsions

So, In the event of significant poisoning, acute renal failure and liver damage are possible. If you discover any of the effects you must immediately reach to the hospital or contact your doctor for further assistance.

• Therapeutic Measures

Most importantly the management of acute poisoning with NSAIDs, including diclofenac, essentially consists of supportive measures and symptomatic treatment. However supportive measures and symptomatic treatment should give for complications Like

• Hypotension
• Renal failure
• Convulsions
• Gastrointestinal disorder
• Respiratory depression.

On the other hand Special measures such as forced diuresis, dialysis, or hemoperfusion are probably of no help in eliminating NSAIDS.  Which also include diclofenac, due to the high protein binding and extensive metabolism.

Voltral Tablets Storage Instructions

Most importantly always keep all the tablets, injections, and syrups out of the reach of the children. On the other hand, keep the tablets within 25 c to 30 c temperature. Further protect from direct sunlight, heat, and moisture. Furthermore, do not use the medicine after the expiry date mentioned on the packing.

More Medical Guide: A Brief Guide Of Acnes Scar Gel Uses Dosage Side Effects Price

What Is Voltral 25 50 100 MG Capsules Tablets Price?

• Price In Pakistan: Rs. 577 PKR
• Price In India: 499 INR
• Price In USA: $ 5 USD In USA

References:-

• https://dawaai.pk/medicine/voltral-4-34810.html
• https://www.dvago.pk/p/voltral-tablets-50-mg-2x10s
• https://www.medicines.org.uk/emc/product/4333/smpc
• https://nexthealth.pk/product/voltral-tablet-50mg-20s-15912/