Aldactone 25 MG 100 MG Tablets

Aldactone Tablets 25 MG and Aldactone Tablets 100mg contains a life saving drug named Spironolactone. Spironolactone is a potassium sparing diuretic. Meanwhile it uses as an antihypertensive agent. Furthermore Spironolactone Tablets used to treat ascites associated with cirrhosis and also use as a diagnostic aid for primary hyperaldosteronism.

 

 

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Composition

Aldactone A 25 MG Tablets: Each Aldactone 25 MG Tablets Contains Spironolactone B.P. = 25Mg

Aldactone 100 MG Tablets: Each Aldactone 100 MG Tablet Contains Spironolactone B.P. = 100MG

 

Indications

Spironolactone (Aldactone Tablets) is indicated in the management of the symptoms like

• Essential Hypertension
• Congestive Heart failure
• Liver cirrhosis accompanied by endema and/ or ascites
• Nephronic cyndrome
• Edemetous conditions
• Diuretic-induced hypokalemia
• Establishing a diagnosis of primary hyperaldosteronism
• Short-term preoparative treatment of patients with primary hyperadosternotism

Aldactone Tablets Dosage

For adults, the daily Aldactone dosage may be given in divided dose or as single daily dose.

Edematous Disorders:

Congestive Heart Failure:

The usual adult dose Aldactone 100 mg/day.If ratio is less than 1.0, 200 to 400 mg/day. However, Maintenance dose should be individually determined.

Cirrhosis:

If urinary NA+/K+ ratio is greater than 1.0, 100 mg/kg. If the ratio is less than 1.0, 200 to 400 mg/day. However, the maintenance Aldactone dose should be individually determined.

Nephrotic Syndrome:

The usual dose Aldactone 100MG to 200 mg/day. However, Spironolactone has not been shown to affect the basic pathologic process, and its use is advised only if other therapy is ineffective.

Edema In Children:

Initial Aldactone dosage is 3 mg/kg body weight daily in divided doses. Meanwhile, Aldactone Dose can adjusted on the basis of response and tolerance. However, If necessary a suspension may prepared by pulverizing Aldactone Tablets with a few drops of glycerine and adding cherry syrup. Such a suspension is stable in one month when refrigerated.

Diagnosis And Treatment Of Primary Hyperaidosteronism:

Spironolactone Tablets may employed as an initial diagnostic measure to provide presumptive evidence of primary hyperaidosteronism while patients are on normal diets.

Long Test:

Daily adult Aldactone dose of 400 mg for three to four weeks. However, Correction of hypokalemia and hypertension provides presumptive evidence or the diagnosis of primary hyperaldosteronism.

Short Test:

Daily adult dose of 400 mg for four days. Meanwhile, If serum potassium increases during spironolactone. But drops when spironolactone is discontinued, a presumptive diagnosis of primary hyperaldosteronism should considered.

Meanwhile, After the diagnosis of hyperaldosteronism has established by more definitive testing procedures, spironolactone may administered in daily dosage of Aldactone 100 to 400 mg in preparation for surgery for patients who considered unsuitable candidates for surgery. Furthermore, spironolactone may employed for long term maintenance therapy at the lowest effective dosage determined for the individual patient.

Hypokalemia / Hypomagnesemia:

Aldactone 25 MG to 100 mg daily may useful in treating diuretic-induced hypokalemia and/or hypomagnesemia. But when oral potassium and/or magnesium supplements are considered inappropriate.

Aldactone Contraindications:

Spironolactone (Aldactone Tablets) contraindicated in patients with

• Acute renal insufficiency
• Significant renal compromise
• Addison’s diseased
• Hyperkalemia or hypersensitivity to spironolactone.

Special Warnings And Special Precautions For use

The Concurrent administration of potassium supplements, a diet rich in potassium, or other potassium-sparing diuretics is not recommended as this may induce hyperkalemia.

Periodic estimation of serum electrolytes is desirable due to the possibility of hyperkalemia, hyponatremia and possible transient BUN elevation, especially in the elderly and/or in patients with preexisting renal or hepatic function. Reversible hyperchloremic metabolic acidosis, usually in association with hypekalemia, has been reported, to occur in some patients with decompensate hepatic cirrhosis, even when renal function is normal interaction with other medicaments and other forms of interaction severe hyperkalemia has been reported in patients co administered potassium-sparing diuretics, including spironolactone, and AGE inhibitors.

Spironolactone potentiates the effects of other diuretics and antihypertensive given concomitantly. The dose of such drugs may be needed to be reduced when spironolactone is added to the treatment regimen. Spironolactone reduces vascular responsiveness to norepinephrine. Caution should be exercised in the management of patients subjected to anesthessia while they are being treated with spironolactone.

Spironolsctone has been shown to increase the half-life of digoxin

Aspirin attenuates the diuretic effect of spironolactone by blocking the secretion of canrenone in the renal tubule. Indomethacin and mefanamic acid have been shown to inhibit the excretion of canrenone.

Spironolactone enhances the metabolism of antipyrine. Spironolactone can interfere with assays for plasma digoxin concentrations.

Aldactone Use During Pregnancy And In Lactation

Safe use in pregnancy has not yet established. Canrenone appears in breast milk if use of spironolactone is essential, an alternative method of infant feeding should be instituted.

Effects On Ability To Drive And Use Machines:

Somnolence and dizziness have been reported to occur in some patients. Caution is advised when driving or operating machinery until the response to initial treatment has been determined.

Aldactone Side Effets

Gynecomastia may develop in association with the use of spironolactone. Meanwhile, the development of gynecomastia related to both dose and duration of therapy. Furthermore, Gynecomastia usually reversible when spironlactone discontinued, although in rare instances, some breast enlargement may persist.

However, of the adverse events reported from experience with spironolactone, the following Aldactone (25MG, 100 MG) Tablets Side Effects, have reported with > 1 % frequencies.

Skin And Appendages:

• Alopecia
• Rash
• Pruritus
• Urticaria
• Hypertrichosis

Endocrine Disorders:

• Breast pain
• Breast neoplasm

Body As A Whole:

• Malaise

Metabolic And Nutritional Disorders:

• Hyperkalemia
• Electrolyte disturbances

Gastrointestinal Disorders:

• Nausea
• Gastrointestinal disturbances

Reproductive Disorders:

• Menstrual disorders

Psychiatric Disorders:

• Confusion
• Changes in libido

Nervous System Disorders:

• Dizziness

Hematologic Disorders:

• Thrombocytopenia
• Leukopenia (including agranulocytosis)

Liver Disorders:

• Hepatic function abnormal

Urinary System Disorders:

• Acute renal failure

Aldactone Tablets Overdose

Acute overdose may be manifested by nausea, vomiting, drowsiness, mental confusion, maculopapular or erythematous rash, or diarrhea. Furthermore in some cases Electrolyte imbalance and dehydration may occur.

In case of any overdose the symptomatic and supportive measures should employed. On the other hand, Induce vomiting or evacuate the stomach by lavage. There no specidic antidote. treat fluid depletion, electrolyte imbalances, and hypotension by established procedures.

On the other hand, Hyperkalemia can treated by the rapid administration of glucose (20 % to 50 % ) and regular insulin, using 0.25 to 0.5 units of insulin per gram of glucose. Moreover, Potassium-(excreting diuretics and ion-exchange resins may also administered, repeating as required. Meanwhile, Spironolactone use should discontinued and potassium intake (including dietary sources) restricted.

Aldactone Drug Interactions

ACE Inhibitors:

Concomitant administration of ACE inhibitors with potassium sparing diuretics has been associated with severe hyperkalemia.

 

Anglotensin II Antagonists, Aldosterone Blockers, Heparin, Low Molecular Weight Heparin, And Other drugs Known To Cause Hyperkalemia:

Concomitant administration may lead to severe hyperkalemia.

 

Alcohol, Barbiturates, Or Narcotics:

Potentiation of orthostatic hyoptension may occur.

Corticosteroids, ACTH:

Intensified electrolyte depletion, particularly hypokalemia, may occur.

Pressor Amines (Like Norepinephrine):

Meanwhile, Aldactone reduces the vascular responsiveness to norepinephrine. Therefore, caution should exercised in the management of patients subjected to regional or general anesthesia while they are treated with aldactone.

 

Skeletal Muscle Relaxants, Nondepolarizing (Like, Tubocurarine):

Possible increased responsiveness to the muscle relaxant may result.

Lithium:

Lithium generally should not given with diuretics. Meanwhile, Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Nonsteroidal Anti-inflammatory Drugs (NSAIDs):

However, In some patients, the administration of an NSAID can reduce the diuretic, natriuretic, and antihypertensive effect of loop, potassium-sparing and thiazide diuretics. Combination of NSAIDs, e.g., indomethacin, eith potassium-sparing siuretics has been associated with severe hyperkalemia. Therefore, when ALDACTONE and NSAIDs used concomitantly, the patients should observed closely to determine if the desired effect of the diuretic is obtained.

Digoxin:

Firstly, ALDACTONE has shown to increase the half-life of digoxin. However, this may result increased serum digoxin levels and subsequent digitalis toxicity. Therefore, It may necessary to reduce the maintenance. And digitalization doses when ALDACTONE administered. And the patient should carefully monitored to avoid over-or under digitalization.

Cholestyramine:

Hyperkalemic metabolic acidosis has reported in patients given ALDACTONE concurrently with cholestryramine.

Drug/Laboratory Test Interactions

Mot importantly, Several reports of possible interference with digoxin radioimmuno assay by ALDACTONE or its metabolits. Neither the extent nor the potential clinical significance of its interference (which may assay-specific) has fully established.

Aldactone Tablets Storage Instructions

Firstly the medicine should sold on the prescription of a registered medical practitioner. Most importantly always store you medical products away out of the reach of your kids. Meanwhile, protect Aldactone from sunlight and heat as well as save it from moisture. Store the medicine on a cool but dry place.

 

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Aldactone (Spironolactone) 25 MG, 100 MG Tablets