Dyl 5MG Desloratadine Tablets Syrup Uses Dosage Side Effects Details
Mainly Dyl 5MG Tablets and Syrup contains a useful and best antihistamine medication named “Desloratadine”. It works by blocking the histaminic reactions in humans and help reduce all type of allergic symptoms.
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Composition Formula Ingredients
- Each Dyl 5 MG Tablet Contains : Desloratadine U.S.P = 5mg
- Each Dyl Syrup 2.5 ML Contains : Desloratadine U.S.P = 2.5 MG
Dyl Tablets Syurup Uses & Indications
For the relief of symptoms of seasonal allergic rhinitis, perennial, ( non-seasonal) allergic rhinitis. Desloratadine is also use for the symptomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
On the other hand, the medicine use the primary active metabolite of loratadine. Non-clinical studies conducted with this medication and loratadine demonstrated that there are no qualitative or quanlitative difference in the toxicity profile of it and loratadine at comparable levels of exposure to desloratadine.
Non-clinical data with medication reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, and toxicity to reproduction. The lack of carcinogenic potential was demonstrated in studies conducted with it and loratadine
Generally the medications used for the treatment of symptoms associated with:
- allergic rhinitis
- urticaria
Dyl Syrup Tablets Dosage & Administration
Adults and adolescent (12 year of age and over):
one tablets once day, with or without meal for the relief of symptoms associated with allergic rhinitis ( including intermittent and persistent allergic rhinitis ) and urticaria.
There is limited clinical trial efficacy experience with the use of desloratadine in adolescents 12 through 17 years of age:
Intermittent allergic rhinitis (presence of symptoms for less than 4 days per week or for less than 4 weeks) should be managed with the evaluation of patients disease history and the treatment could be discontinued after symptoms are resolved and reinitiated upon there reappearance.
In persistent allergic rhinitis(presence of symptoms for 4 days or more per weeks and for more than 4 weeks), continued treatment may be proposed to the patients during the allergen exposure periods.
Contraindications
Hypersensitivity to the action substance, to any of the excipients, or to loratadine.
Warning And precautions
Efficacy and safety of these tablets in children under 12 years of age have not been established. In the case of severe renal insufficiency, it should be used with caution. Patients with rare hereditary problem of galactose intolerance, the deficiency or glucose galactose malabsorption should not take this medicine.
Interaction with other medicinal products and other forms of interaction
No clinically relevant interaction were observed in clinical trials with these syrup or tablets in which erythromycin or ketoconazole were co-administered.
In a clinical pharmacology trial the medications taken concomitantly, with alcohol did not potentiate the performance effect of alcohol.
Use In Pregnancy And Lactation
Desloratadine was not teratogenic in animals studies. The safety use of the medicinal product during pregnancy has not been established. The use of this drug during pregnancy is therefore not recommended.
It also excreted into breast milk, therefore the use of these type of medicine not recommended in breastfeeding women.
Effects on ability to drive and use machines
In clinical trials assessed the driving ability, no impairment occurred in patients receiving this medications. However, patients should informed that very rarely some people experience drowsiness, which may effect their ability to drive or use machines.
DYL Undesirable effects
In clinical trial in a range of indication including allergic rhinitis and chronic idiopathic urticaria, at the recommended dose of 5 mg daily, undesirable effect with desloratadine reported in 3% of patients in excess of those treated with placebo. The most frequent of adverse event reported in excess of placebo were fatigue (1.2%) dry mouth (0.8%) and headache(0.6%). In clinical trial with 578 adolescents patients, 12 thought 17 years of age, the most common adverse event shown headache. Which occurred in 5.9% of patients treated with it to 6.9% of patients receiving placebo. Other undesirable effect reported very rarely during the post-marketing period listed in the following
- Psychiatric disorder
- Hallucinations
- Nervous system disorders
- Dizziness
- somnolence
- insomnia
- psychomotor hyperactivity
- seizures
- Cardiac disorder
- Tachycardiac
- palpitations
- Gastrointestinal disorders
- abdominal pain
- nausea
- vomiting
- dyspepsia
- diarrhoea
- Hepatobiliary disorders
- Elevations of liver enzymes
- increased bilirubin
- hepatitis
General disorder and administration site conditions like
- Hypersensitivity reaction
- anaphylaxis
- angioedema
- prurititus
- rash
- urticaria
Overdose Symptoms & Treatment
In the event of overdose, consider standard measures to remove unabsorbed active substance. Symptomatic and supportive treatment recommended.
Based on a multiple dose clinical trials, in which up to 45 mg of desloratadine administered (nine time the clinical dose), no clinically relevant effect observed.
Tablets and Syrups not eliminated by hemodialysis; It not eliminated by peritoneal dialysis.
Dyl Syrup Tablets Desloratadine Side effects
Like all medicine, Desloratadine can cause side effect, although not everybody gets them. During the marking of medicines allergic reaction (difficulty in breathings, wheezing, itching, hives and swelling) have reported very rarely ( in less than 1 user in 10,000 ). Seek immediate medical care if this occurs.
In adults, side effect were about the same as with a dummy tablets. However, fatigue dry mouth and headache were reported more often than with a dummy tablets. In adolescents, headache seen the most commonly reported side effect.
Very rare side effect (affect less than 1 user in 10,000) reported during the marketing:
- Palpitation
- rapid heartbeat
- stomach pain
- nausea(feeling sick)
- vomiting
- upset stomach
- diarrhoea
- dizziness
- drowsiness
- inability to sleep
- muscle pain
- hallucinations
- seizures
- restlessness with increased body movement
- liver inflammation
- abnormal liver function tests.
If any of the side effect gets serious, or if you notice any side effect not listed in this page, please tell your doctor or pharmacist.
Dyl Tablets Syrup Medicine Storage Instructions
Firstly, store all Dyl products including capsules and syrup below 30 C temperature. On the other hand, also protect these syrup capsules from direct sun light and heat exposure as it may affect the formula of the medicine. Most importantly, always keep it away from your children to avoid their health any type of side effects. Lastly, before start using this medicine always check the Dyl packing for its expiry date printed on each pack. And if the medicine syrup capsules are expired please do not use it as it may become a serious threat to your life.
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