Depo Medrol Injection 2ML 40MG Dosage Uses Side Effects Ingredients Formula Price

Depo Medrol Injection 40 MG 80 MG Uses

Depo Medrol Injections contains Methylprednisolone in it which is a class of drugs called steroids. It is an corticosteroid and medrol drug. On the other hand, it reduce swelling and inflammation. Meanwhile the action, uses and side effects are similar to prednisone.

What Is Methylprednisolone And What It Used For?

Methylprednisolone medication is generally a synthetic glucocorticoid which belongs to the drug class of corticosteroids related to the steroid hormones family. Generally it used for the treatment of symptoms cured with its anti inflammatory and immunosuppressive effects in patients. Moreover, it sold under different brand names in the world like Depo Medrol, Medrol and Solu Medrol injections. Generally Methylprednisolone work as an mineralocorticoid as well as glucocorticoid receptor agonists. Firstly, the medication found during studies in year 1950. However, it first approved to use in medicines in USA in year 1957.

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Depo-Medrol Uses & Indications

Depo Medrol Injections indicated in:

• Allergy
• Angioneurotic edema
• Asthma
• Autoimmune disease
• Collagen disease
• Crohn’s disease
• Dermatological Disease
• Eczema
• Endocrine disorder
• GI disease
• Graft Rejection
• Leukaemia
• Lymphoma
• Multiple sclerosis
• Nephrotic syndrome
• Occular inflammation
• Opthalmic disease
• Rejection of organ transplants
• Renal disease
• Termination of pregnancy of 1324 week gestation
• Traumatic injuries

For Intramuscular Administration

When oral therapy is not feasible and the strength, doses form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intramuscular use of methylprednisolone acetate is indicated as follows:

Endocrine Disorders:

Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance)

Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice, mineralocorticoid supplementation may be necessary, particularly when synthetic analogs are used).

• Congenital adrenal hyperplasia
• Hypercalcemia associated with cancer
• Nonsuppurative thyroidities

Rtheumatic Disorder

As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

• Post-traumatic osteoarthritis
• Epicondylitis
• Synovitic of osteorthritis
• Acute nonspecific tenosynovitis
• Rheumatoid arthritis, inculding juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)
• Psoriatic arthritis
• Ankylosing spondylitis
• Acute and subacute bursitis

Collagen Diseases

During an exacerbation or as maintenance therapy in selected cases of:

• Systemic lupus erythematosus
• Systemic dermatomyositis (polymyositis)
• Acute rheumatic carditis

Dermatologic Diseases

• Pemphigus
• Bllous dermatitis herpetiformis
• Severe erythema multiforme (Stevens-Johnson syndrome)
• Severe seborrheic dermatitis
• exfoliative dermatitis
• Mycosis fungoides
• Severe psoriasis

Allergic states

Control of severe or incapacitating allergic conditions intractable to adequate trial of conventional treatment in:

• Bronchial asthma
• Drug hypersensitivity reactions
• Contact dermatitis
• Urticarial transfusion reactions
• Atopic dermatitis
• Acute non-infections laryngeal edema (epinephrine is the drug of first choice
• Serum sickness
• Seasonal or perennial allergic rhinitis

Ophthalmic Diseases

Severe acute and chronic allergic and inflammatory processes involving the eye, such as:

• Herpes zoster ophthalmicus
• Drug hypersensiitivity reactions
• Iritis indocycitis
• Anterior segment inflammation
• Chorioretinitis
• Allergic conjunctivitis
• Diffuse posterior uveitis
• Allergic corneal marginal ulcers
• Optic neuritis
• Keratitis

Gastrointestinal Diseases

To tide the patient over a critical period of the disease in:

• Ulcerative colitis (systemic therapy)
• Regional enteritis (systemic therapy)

Respiratory Diseases

Fulminating or disseminated pulmonary tubercuiosis when used concurrently with appropriate anti-tubeculous chemotherapy

• Symptomatic sarcoldosis
• Berylliosis
• Loeifier’d syndrome not manageable by other means
• Aspiration peumonitis

Hematologic Disorders

• Acquired (autoimmune) hemolytic anemia
• Erythrobiastorperia (RBC anemia)
• Secondary thrombocytopenia in adults
• Congenital (erythroid) hypoplastic anemia

Neoplastic Diseases

For palliative Management of:

• Leukemia and lymphomas
• Acute leukemia of childhood

Edematous Status

To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus

Nervous System

• Acute exacerbations of multiple scierosis.

Miscallaneous

• Tuberculous meningitis with subarachnoid block or impending block when used concumently with appropriate anti-tuberculous chemotherapy.
• Trichinosis with neurologic or myocardial involvement.

B. FOR INTRA-SYNOVIAL OR SOFT TISSUE ADMINISTRATION (including peri-articular and intrabursal) SEE 4.4 SPECIAL WARNING AND PRECAUTIONS FOR USE

Methyprednisolone acetate is indicated as adjunctive therapy for shot-term administration (to tide the patients over an acute episode or exacerbation) in:

• Synovitis of osteoarthritis
• Epiccondylitis
• Rheumatoid arthritis
• Acute non specific tenosynovitis
• Acute and subacute bursitis
• Post traumatic osteoarthritis
• Acute gouty arthritis

C. For Intralesional Administration

Methylprednisolone acetate indicated for intralesional use in the following conditions.

Keloids, Localized hypertropic, Infiltrated, Inflammatory lesions of:

• Lichen planus, psoriatic plagues
• Discoid lupus erythematosus
• Necrobiosis lipodica diabeticorum
• Granuloma annulare
• Lichen Simples chronicus
• Alpecia areata

Methylprednisolone acetate may also useful in cystic tumors or an aponeurosis or tendon.

D. For Intrarectal Installation

• Ulcerative colitis

Depo-Medrol 40 80 MG Injection Dosage And Method Of Administration

Because of physical incompatibilities, Depo Medrol 40 MG 80 MG Injections should not diluted or mixed with other solutions. On the other hand, Parenteral suspensions should inspected visually for any foreign particulate matter and discoloration prior to administration whenever drug product and container permit.

Administration For Local Effects

Therapy with methylprednisolone acetate does not obviate the need for the conventional measures usually employed. Although this method of treatment will ameliorate symptoms. It is in no sense a cure and the hormone has no effect on the cause of the inflammation.

1. Rheumatoid and Oesteoarthritis. The dose for intra articular administration depends upon the size of the joint and varies with the severity of the condition in the individual patient. In chronic cases, injections may repeated at intervals ranging from one to five or more weeks depending upon the degree of relief obtained from the initial injection.
2. Bursitis: The area around the injection site prepared in a sterile way and a wheal at the site made with 1% procaine hydrochloride solution. A 20 to 24 gauge needle attached to a dry syringe inserted into the bursa and the fluid aspirated. Meanwhile the needle is left in place and the aspirating syringe changed for a small syringe containing the desired dose. After injection the needle is withdrawn and a small dressing applied.
3. Miscellaneous: Gangilon, Tendinitis, Epicondylitis. In the treatment of conditions such as tendinitis or tenosynovitis, care should taken following application of a suitable antiseptic to the overlying skin, to inject the suspension into the tendon sheath rather than into the substance of the tendon. The tendon may rapidly palpated when placed on a stretch. When treating conditions such as epicondylitis, the area of greatest tenderness should outlined carefully and the suspension injected directly into the cyst. However, in many cases a single injection causes a marked decrease in the size of the cystic tumor and may affect disappearance. The usual sterile precautions should observed of course with each injection.

Depo Medrol 40 80 Inj Contraindications

Depo Medrol Injections contraindicated in.

• In patients who have systemic fungal infections
• In patients with known hypersensitivity to methylprednisolone or any component of the formulation
• For use by the intrathecal route of administration
• Use by the epidural route of administration
• For use by the intravenous route of administration

Administration of live or live, attenuated vaccines is contraindicated in patients receiving immuno suppressive doses of corticosteroids.

Depo Medrol Injection Shot Special Warnings & Precautions

MGPC formulation

Depo Medrol Injection is not suitable for multi dose use. Following administration of the desired dose, any remaining suspension should be discarded.

Benzyl Alcohol formulation

This product contain benzyl alcohol which is potentially toxi when administration locally to neural tissue.

Multi dose use of methylprednisolone acetate from a single vial requires special care to avoid contamination. Although initially sterile, any multi dose use of vials may lead to contamination unless strict aseptic technique is observed. Particular care, such as use of disposable sterile syringes and needles, is necessary.

While crystals of adrenal steroids in the dermis suppress inflammatory reaction. Their presence may cause disintegration of the cellular elements and physicochemical changes in the ground substance of the connective tissue. The resultant infrequently occurring dermal and/or subdermal changes may from depressions in the skin at the injection site. The degree to which this reaction occurs will vary with the amount of adrenal steroid injected. Regeneration is usually complete within a few months or after all crystals of the adrenal steroid have been absorbed.

Severe medical events have been reported in association with the intrathecal/epidural routes of administration (see section Undesirable Effects). Appropriate measures must be taken to avoid intramuscular injection.

Depo Medrol Injection Drug Interactions

Methylprednisolone is a cytochrome P450 enzyme (CYP) substrate and is mainly metabolized by the CYP3A enzyme. CYP3A4 is the dominant enzyme of the most abundant CYP subfamily in the live of adult human. It catalyzes 6B-hydroxylation of steroids, the essential Phase I metabolic step for both endogenous and synthetic coeticosteroids. Many other componds are also substrates of CYP3A, some of which (as well as other drugs) have been shown to alter glucocorticoid metabolism by induction (upregulation) pr inhibition of the CYP3A4 enzyme.

CYP3A4 Inhibitors

Drug that inhibit CYP3A4 activity generally decrease hepatic clearance and increase the plasma concentration of CYP3A4 substrate medication, such as methylprednisolone. In the presence of a CYP3A4 inhibitor, the dose of methylprednisolone may need to be titrated to avoid steriod toxicity

CYP3A4 Induces

Drug that induce CYP34 activity generally increase hepatic clearance, resulting in decreased plasma concentration of medicines that are subtrates for CYP3A4. Coadministration may require an increase in methylprednisolone dosage to achieve the desired result.

CYP3A4 Substrates

In the presence of another CYP3A4 substrate, the hepatic clearance of methylprednisolone may be affected, with corresponding dosage adjustments required. It is possible that adverse events associated with the use of either drug alone may be more likely to occur with coadministration.

Depo Medrol 40 80 Inj Use In Pregnancy And Lactation

Depo Medrol In Fertility:

There is no evidence that corticosteroid impair fertility.

Depo Medrol Injections In Pregnancy:

Some animals studies shown that corticosteroids, when administered to the mother at high doses, may cause fetal malformation. On the other hand, Adequate human reproduction studies have not been done with corticosteroids. Therefore the use of this drug in pregnancy, nursing mother, or woman of child bearing potential risk to the mother and embryo or fetus. Since there is inadequate evidence of safety in human pregnancy, this drug should be used in pregnancy only if clearly needed.

However, Corticosteriods readily cross the placenta. One retrospective study found an increased incidence of low birth weight in infants born of mothers receiving corticosteroids.

Meanwhile, Infants born of mother who have received substantial doses of corticosteroids during pregnancy must be carefully observed and evaliated of sigms of adrenal insufficiency. Although neonatal adrenal insufficiency appears to be rare in infants who were exposed in utero to corticosteroids.

Cataracts have been observed in infants borns of mothers treated with long term corticosteroids during pregnancy.

Therefore no known effects of corticosteroids on labor and delivery.

Depo Medrol Injections Use In Lactation:

Most importantly, Corticosteroids excreted in breast milk.

Meanwhile, Corticosteroids distributed into breast milk may suppress growth and interfere with endogenous glucocorticoid production in nursing infants. Therefore, Since adequate reproductive studies have not performed in humans with glucocorticoids. Meanwhile, these drugs should administered to nursing mothers only if the benefits of therapy judged to outweight the potential risks to the infant.

Depo Medrol Injections Effects On Driving Vehicles And Machines

However, The effect of corticosteroids on the ability to drive or use machinery has not been systematically evaluated. Therefore, Undesirable effects, such as dizziness, vertigo, visual disturbances, and fatigue possible after treatment with corticosteroids. However, if affected, patients should not drive or operate machinery.

Depo Medrol Methylprednisolone 40 80 Injection Side Effects

The following Depo Medrol adverse reactions have been reported with the following routes of administration:

• Intrathecal/Epidural
• Arachnoiditis
• Functional gastrointestinal disorder
• Bladder dysfunction
• Headache
• Meningitis
• Parapareisis
• Paraplegia
• Convulsions
• Sensory disturbances

The frequency of these adverse reaction not known.

More Depo Medrol Injections Side Effects

Infections And Infestations:

Opportunistic infection, Infection, Peritonitis, Injection site infection

Blood And Lymphatic System Disorders

Leukocytosis

Immune System Disorders

Drug Hypersensitivity, Anaphylactic reaction, Cushingoid, Hypopituitarism, Steroid withdrawal syndrome

Metabolism And Nutrition Disorders

Lipomatosis, Sodium retention, Fluid retention, Alkalosis hypokalaemic, Dyslipidemai, Glucose tolerance impaired, Increased insulin requirement, Increased appetitie.

Pychiatric Disorders

Firstly,Affective disorder, Depressed Mode, Euphoric mood, Affect lability, Drug dependence, Suicidal ideation, Psychotic disorder have studied. Furthermore, Mania, Delusion, Hallucination, Schizophrenia, Mental disorders, Personality change, Confusional state, Anxiety, Mood swings, Abnormal behaviour, Insomnia.

Nervous System Disorders

Epidural lipomatosis, Intracranial pressure increased, Convulsion, Amnesia, Cognitive disorder, Dizziness, Headache.

Eye Disorders

Central serous chorioretionapathy, Blindness, Cataract, Glaucoma, Exophthalmos.

Ear And Labyrinth Disorders

Vertigo

Cardiac Disorders

Furthermore, the Cardiac failure congestive also noticed.

Vascular Disorders

Thrombosis hypertension, Hypotension, Pulmonary embolism, Hiccups

Respiratory, Thoracic And Mediastinal Disorders

Pulmonary Embolism, Hiccups

Gastrointestinal Disorders

Peptic Ulcer, Intestinal perforation, Gastric Haemorrhage, Pancreatitis, Oesophagitis ulcerative, Oesophagitis, Abdominal distention, Abdominal pain, Diarrhoea, Dyspepsia, Nausea.

Skin And Subcutaneous Tissue Disorders

Angioedema, Hirsutism, Skin atrophy, Petechiae, Ecchymosis, Erythema, Hyperhidrosis, Pruritus, Rash, Urticaraia, Skin striae, Skin hyperpigmentation, Skin hypopigementation, Acne.

Musculoskeletal And Connective Tissue Disorders

Moreover, Muscular weakness, Myalgia, Myopathy, Muscle atrophy, Osteoporosis, Osteonecrosis, Pathological fracture, Neuropathic arthropathy, Arthralgia, Growth retardation

General Disorders And Administration Site Conditions

Furthermore, Abscess sterile, Oedema peripheral, Impaired healing, Fatigue, Malaise, Irriability, Injection site reaction.

Investigations

• Intraocular pressure increased
• Carbohydrate tolerance decreased
• Blood potassium decreased
• Nitrogen balance negative
• Urine calcium increased
• Alanine aminotransferase increased
• Aspartate aminotransferase increased
• Blood alkaline phosphatase increased
• Blood urea increased
• Suppression of reactions to skin tests

Depo Medrol Methylprednisolone Acetate 40 80 MG Overdosage

However, There is no clinical syndrome of acute Depo Medrol overdosage with methylprednisolone acetate. Reported of acute toxicity and/or death following overdosage of corticosterids are rare. Meanwhile, In the event of overdosage, no specific antidote is available; treatment is supportive and symptomatic, Methylprednisolone is dialyzable.

Depo Medrol Injections Storage Instructions

Firstly, Shake well before using the product. Most importantly always keep all the medicines out of the reach of your kids. On the other hand, Store Depo Medrol below 30 C temperature. Furthermore, also protect the injection from sun light and heat. Lastly, you must always check all the medications expiry date which always print on the packing. And if the product is expired you must not use it to save your life.

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Depo Medrol Injections Methylprednisolone Acetate 40 MG 80 MG Price In India USA Pakistan