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Adalat Best Nifedipine Tablets Uses Dosage Side Effects

Adalat La Tablets are the brand name of a very useful life saving medicine named Nifedipine in it. Nifedipine tablets considered as synthetic origin and belongs to Pyridine drug family. However it belongs to Calcium L-channel antagonist pharmacological group based on mechanism of action of this medication. On the other hand Nifedipine molecular weight is 346.30. It considered as one of the best calcium channel blocker used for the treatment of angina, high blood pressure patients, premature labor or raynaud phenomenon patients. Generally works by relaxing the blood vessels which help them to improve the blood flow and make patients feel relax.

 

 

Adalat LA Best Nifidipine Tablets Uses & Indications

• Treatment Of Coronary Heart Disease

Chronic stable angina pectoris (angina of effort).

• Treatment Of Hypertension

Treatment of 6321 hyprtensive patients with at least one additional risk factor followed over 3 to 4.8 years in a multi national, randomised, double-blind, prospective study. However Nifedipine shown to reduce cardiovascular annd cerebrovascular events to a comparable degree as a standard diuretic combination.

Adalat La Nifidipine Tablets Dosage Administration

As far possible the treatment must tailored to the needs of the individual. Meanwhile, Depending on the clinical picture in each case, the basic dose must introduced gradually. Therefore, Unless otherwise prescribed, the following Adalat Dosage guidelines recommended for adults.

 

 

• For Coronary Heart Disease

Chronic stable angina pectoris (angina of effort)

1 Adalat LA 30 mg tablet once daily (1*30 mg/day)

1 Adalat LA 30 mg tablet once daily (1*60 mg/day)

• Dosage For Deart Disease

One Adalat LA 30 mg tablet once daily (1*30 mg/day)

1 Adalat LA 60 mg tablet once daily (1*60 mg/day)

• Dosage For Hypertension

One Adalat LA 30 mg tablet once daily (1*30 mg/day)

1 Adalat LA 60 mg tablet once daily (1*60 mg/day)

In general therapy should initiated with with Adalat Nifidipine 30 mg once daily.

Where registered a starting dose of Adalat Nifidipine 20 mg once daily may considered when medically indicated. However, Depending on the severity of the disease and the patient’s response the dose can increased in the recommendation to adept the Nifedipine dose not to use Nifedipine at all.

Adalat La Nifidipine Tablets Duration Of Treatment

The attending doctor will determine the duration of the treatment with Adalat La 20 MG, 30 MG Tablets.

Adalat LA Nifidipine Administration

As a rule Adalat La Tablet are swallowed whole with a little liquid, irrespective of meal times. On the other hand, Grapefruit juice must avoided.

 

Adalat La Nifidipine Tablet Special Populations

Children And Adolescents

The safety and efficacy of Adalat la in children below 18 years has been established.

Geriatric Patients

Based on pharmacokinetic data for Adalat LA no dose adaptation in elderly above 65 years is necessary.

Patients With Hepatic Impairment

In patients with impaired liver function, careful monitoring and, in severe, a dose reduction may be necessary.

Patients With Renal Impairment

Based on pharmacokinetic data no dosage adjustment required in patients with renal impairment.

Best Nifedipine Adalat La Tablet Contraindications

Adalat La Tablets must not used in cases of known hypersensitivity or to any of the excipients.

• Nifediqine is contraindicated in pregnancy before week 20 mg during breastfeeding.
• Adalat LA must not be used in cases of cardiovascular shock. On the other hand, Adalat la must not used in patients with kock pouch.
• Nifedipine must not used in combination because no efficient plasma levels of Nifedipine may obtained due to enzyme induction.

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Adalat LA Best Nifidipine Tablets Interactions

Products That Affect Nifedipine

Firstly, Nifedipine is metabolised via the cytochrome P450 3A4 system. On the other hand it Located both in the intestinal mucosa and in the liver. So, Products that are known to either inhibit or to induce this enzyme may therefore alter the first pass (after oral administration ) or the clearance of Nifedipine.

Most importantly, The extent as well as the duration of interactions should taken into account when administering Nifedipine together with the followings:

Rifampicin

Rifampicin strongly induces the cytochrome P450 3A4 system. Upon co-administration with rifampicin, the bio-availability of nifedipine distinctly reduced and thus its efficacy weakened. Most importantly, the use of Nifedipine in combination with it contra-indicated.

Macrolide Antibiotidcs (E.G Erythromycin)

However, No interaction studies have carried out between nifedipine and macrolide antibiotics. Meanwhile, Certain macrolide ntiblotics known to inhibit the cytochrome P450 mediated metabolism of other products. Therefore the potential for an increase of nifedipine plasma concentrations upon co-administration of both products cannot excluded.

• Azithromycin, although structurally related to the class of macrolide antibotics is void of CYP3A4 inhibition.

Anti-Hiv Protease Inhibitors (e.g. Ritonavir)

However, A clinical study investigating the poteritial of a product interaction between nifedipine and certain anti-hiv protease inhitors has not yet performed. Therefore, tablets of this class known the cytocrome P450 system. In addittion, products of this class have shown to inhibit in vitro the cytochrome P450 3A4 mediated metabolism of nifedipine. Meanwhile, When administered together with nifedipine, a substantial increase in plasma concentrations of nifedipine ue to a decreased forst pasa matabloism cannot excluded.

Fluoxetine

However in A clinical study investigating the potential of a tablets interaction between nifedipine and fluoxetine has not yet performed. Meanwhile, Fluoxetine has been shown to inhibit the cytochrome P450 3A4 mediated metabolism of nifedipine. Therefore an increase of nifedipine plasma conxentrations upon co-administration of both tablets cannot be excluded.

Nefazodone

Meanwhile, in A clinical study investigating the potential of a tablet interaction between nifedipine and nafazodone has not yet been performed. Therefore, Nefazodone is known the cytochrome P450 3A4 mediated metabolism of other tablets. However an increase of nifedipine plasma concentrations upon co-administrations of both tablets cannot be excluded.

Quinupristin/Dalfopristin

Simultaneous administration of quinuprinstin/dalfopristin and nifedipine may lead to increased plasma concentrations of nifedipine.

Valproic Acid

However, No formal studies have performed to investigate the potential interaction between nifedipine and valproic acid. Therefore, As valproic acid has shown to increase the plasma concentrations of the structurally similar calcium channel blocker nimodipine due to enzyme inhibition. So, An increase in nifedipine plasma concentrations and hence an increase in efficacy excluded Cimetidine

However, Due to its inhibition of cytochrome P450 3A4 elevates the plasma concentration of nifedipine and may potentiate the antihyoertensive effect.

Cisapride

Simultaneous administration of cisapricde and nifedipine may lead to increased plasma concentrations of nifedipine.

Phenytoin induces the cytochrome P450 3A4 system. However, Upon co-administration with phenytoin, the bioavaillability of nifedipine reduced and thus its efficacy weakened. Meanwhile, When both products concomitantly administered, the clinical response to nifedipine should monitored. And, if necessary, an increase of the nifedipine dose considered. On the other hand, If the dose of nifedipine increased during co-administration of both products, a reduction of the nifedipine dose considered when the treatment with phenytoin discontinued. However, No formal studies have performed to investigate the potential interaction between nifedipine and carbamazepine or phenobarbitone. However, both products have shown to reduce the plasma concentrations and hence a decrease in efficacy cannot excluded.

Effects Of Nifedipine Lowering Tabletss:

Blood Pressure lowering Tabletss

Most importantly, Nifedipine May Increase Th Blood Pressure Lowering Effect Of Concomitant Applied Antihypertensives, such As:

• Diuretics,
• b-Blockers,
• ACE-Inhibitors,
• Angilotergic 1 (AT1) receptor-antagonists,
• Other calcium antagonists,
• A-adrenergic blocking agents,
• PDE5 inhibitors,
• A-methyldopa,

Therefore, When nifedipine administered simultaneously with B-receptor blockers the patient should carefully monitored. So, Since deterioration of heart failure also known to develop in isolated cases.

Digoxin

However, the simultaneous administration of nifedipine and digoxin may lead to reduced digoxin clearance and hence an increase in plasma concentrations of digoxin. Therefore, the patient should checked for symptoms of digoxin overdosage as a precaution. And, if necessary, the glycoside dose should reduced taking account of the plasma concentration of digoxin.

Adalat Nifidipine Tablets Use In Pregnancy And Lactation

Adalat In Pregnancy

Most importantly, Nifedipine contraindicated in pregnancy before week 20. However, there are no adequate and well controlled studies in pregnant women. Meanwhile, In animal studies nifedipine has shown to produce embryotoxicity, fetoxicity and teratogenicity. On the other hand, Nifedipine passes into the breast milk. As there is no experience of possible effects on infants, breastfeeding should first stopped if nifedipine treatment becomes necessary during the breastfeeding period.

In-Vitro Fertilization

However, In single cases of in vitro fertilization calcium antagonists like nifedipine associated with reversible blochemical changes in the spermatozoa’s head section. On the other hand, that may result in impaired sperm function. However, in those men who repeatedly unsuccessful in fathering a child by in vitro fertilization. And where no other explanation can found, calcium antagonists like nifedipine should considered as possible causes.

Effects On ability To Drive And Use Machines

Meanwhile, Reactions to the Products, which vary in intensity from intensity from individual to individual, can impair the drive or to operate machinery. However, This applies particularly at the treatment, in changing the medication and in combination with drinks.

Adalat Nifidipine Tablet Side Effects

Adverse tablets reactions (ADRs) based on placebo-controlled studies with Nifdipine sorted by CIOMS 3 categories of frequency listed below: ADRs listed under “common” observed with a frequency below 3 % with the exception of oedema (9.9 %) and headache (3.9 %). Meanwhile you might get the side effects like

• Diziness
• Flushing
• Weakness feeling
• Swelling Of Ankles
• Swelling of feets
• Headaches
• Constipation
• chest pains
• shortness of breath
• left arm pain

Best Nifedipine Tablets Adalat La Overdosage Symptoms And Treatment

Nifidipine Tablets Overdosage Symptoms

The following symptoms observed in cases of severe nifedipine intoxication. Disturbances of consciousness to the point of coma. a drop in blood pressure, tachycardiac / bradycardiac heartrhythm disturbances, hyperglycaemia, metabolicacidosis, hypoxia, cardiogenic shock with pulmonary oedema.

Management Of Overdose

As far as treatment concerned, elimination of the active substance and the restoration of stable cardiovascular conditions have priority. However, After oral ingestion thorough gastric lavageindicated. Meanwhile If necessary in combination with irrigation of the small intestine. Particularly in cases of intoxication with slow-release products like Adalat LA elimination must as complete as possible, including the small intestine, to prevent the otherwise inevitable subsequent absorption of the active substance. On the other hand, Haemodialysis serves no purpose, as nifedipine not dialysable, but plasmapheresis advisable (high plasma protein binding, relatively low volume of distribution).

Braducardiac heart rhythm disturbances may treated symptomatically with B-sympathomimetics. And in life-threatening bradycardiac disturbances of heart rhythm temporary pacemaker therapy can advisable. However, Hypotension as a result of cardiogenic shock and arterial vasodilation can treated with calcium (10-20 ml of a 10 % calcium gluconate solution administered slowly I.V. and repeated if necessary). As a result, the serum calcium can reach the upper normal range to slightly elevated levels. Meanwhile, If an insufficient increase in blood pressure achieved with calcium, vasoconstricting sympathomimetics such as doparmine or noradrenaline additionally administered. Therefore, the dosage of these productss determined solely by the effect obtained. Additional liquid or volume must administered with caution because of the danger of overloading the heart.

Adalat LA Tablets Storage Instructions

Most importantly keep all the tablets out of the reach of the children. On the other hand do not store Adalat Tablet above 30 C temperature. Also protect this products from direct sunlight and heat. Lastly, do not use nifedipine tablets after the expiry date which always printed on each packing of the medications.

 

Best Nifedipine Tablets Adalat LA (20 MG, 30 MG) Price