Berica Tablet Uses
Berica Tablet (Etoricoxib) is a member of new class of arthritis/analgsia medications call coxibs. On the other hand Mechanism of action of Etoricoxib an oral, selective syclo-oxygenase-2 (COX-2) inhibitor. Meanwhile Etoricoxib produced dose-dependent inhibition of Cox-2 without inhibition of COX-1 at doses up 150 mg daily. On the other hand it doses not inhibit gastric prostaglandin synthesis and has no effect on platelet function. Likewise selective inhibition prodtaglandin sunthesis the synthesis of prostanoid mediators of. Pain, inflammation, and fever with decreased potential GL torcity and effects on platelet aggregation.
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Qualitative & Quantitative Composition
Berica tablet 60 mg each film-coated tablet contains : Etoricoxib 60 MG
Berica Tablet Special Population
Hepatic Impairment
Meanwhile the Patients with mild hepatic dysfunction (child-pough score 5-6). In addition the administration 60 mg once daily has an approximately 16% higher mean Auc as compared to healthy subjects given the same regimen. On the other hand Patients with moderate hepatic dysfunction (child-pugh score 7-9). In addition, administered 60 mg every other day has similar mean Auc to the healthy subjects given 60 mg daily.
Berica (Etoricoxib) 60mg Tablets Uses & Indications
That is to say, Berica (etoricoxib) Tablet uses for the treatment of:
- Symptomatic relief of osteoarthritis (OA) and rheumatoid athritis (RA)
- The management of ankylosing spondylitis (As)
- Treatment of acute gouty arthritis
- Relief of acute pain relief of chronic musculoskeletal pain associated with dental surgery
- Treatment of moderate to severe acute post-operative pain associated with abdominal gynecological surgery
Tab Berica (Etoricoxib) Dosage Administration
Osteoarthritis
The recommended dose is 30 mg or 60 mg once daily.
Rheumatoid Arthritis & Ankylosing Spondylitis
The recommended doses 90 mg once daily.
Acute Gouty Arthritis
Meanwhile The recommended dose is 120 mg daily. However 120 mg should used only for the acute symptomatic period. Moreover it is limited to a maximum of 8 days treatment.
Acute pain
Meanwhile The recommended doses is 120 mg daily. However the 120 mg should be used only for the acute symptomatic period. Therefore it limited to a maximum of 8 days treatment.
Chronic Musculoskeletal Pain
Further The recommended dose is 60 mg once daily.
Primary Dysmenorrhea
Meanwhile The recommended dose is 120 mg once daily.
Post-operative Dental Pain
Most importantly The recommended dose is 90 mg once daily.
Post-operative Gynecological Pain
Meanwhile The recommended dose is 90 mg once daily. The initial should administered shortly before surgery. However The dose can be increased to a maximum 120 mg once daily.
On the other hand it may be taken with or without food. However Cardiovascular risks of this product may increase with dose and duration of exposure. On the other hand the shortly duration possible and the lowest effective should dose should used. However The patient’s need for symptomatic relief. And response to therapy should re-evaluated periodically, especially in patients with osteoarthritis.
Special Population
Hepatic” Imairment regardless of indication, in patients with mild hepatic dysfunction (child-pugh score 5-6)a dose of 150 mg once daily should not exceeded. However In patients with with moderate hepatic dysfunction (child-pugh score 7-9) regardless of indication the dose of 60 mg every other day should not exceeded. However administration of 30 mg once daily can also be considered.
Berica (Etoricoxib) Tablet Side Effects
Most importantly, Like all the other tablets and other products Berica has also shown some side effects. However not everyone gets them these includes.
Common Side Effects
- Alveolar Osteitis
- Oedema/ fluid retention
- Dizziness
- Headache
- Palpitations
- Hypertension
- Gastrointestinal disorders
- Abdominal pain
- Flatulence
- Heatburn
- Diarrhea
- Dyspesia
- Epigastric discomfort
- Nausea
- ALT increased
- AST increased
- Acchymosis
- Asthenia/fatigue
- Flu-like disease.
Uncommon Side Effects
- Gastroenterities Upper respiratory infection
- Urinary tract infection Anemia
- Leukopenia Thromboctopenia
- Weight Gain Increase or decrease appetite
- Anxiety Depression
- Mental acuity decreased Dysgeusia
- Insomnia Paresthaesia/hypaesthia
- Somnolence Blurred vision
- Conjuetivitis Tinnitus
- Vertigo Atrial fibrillation
- Congestive heart failure Angina pectoris
- Myocardial infarction Flushing
- Cerebrovaseilar accident Transient ischemic attack cough
- Dyspnea Epistaxis
- Abdominal distention Acid reflux bowel movement pattern change constipation
- Dry mouth Gastroduodena
- Ulcer Irritable bowl syndrome
- Oesophapities Oral ulcer
- Vomiting Gastritis
- Facial oedema prurilus Rash
- Muscular Cramp/spasm
- Musculoseletal pain Stifftness proteinuria
- Serum creatinine increased Chest pain
- Hyperkaiemia Blood nitrogen increased creatine phosphokinase increased
Rare Side Effects
That is to say it can Erytheama and blood sodium decreased.
Very Rare Side Effects
- Angloeciema
- Shock
- Confusion
- Hallucination
- Hypertensive crisis
- Bronchospasm
- Peptic ulcers
- Gastroinestinal perforation and bleeding
- Hepatitis
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Renal insufficiency including renal failure
Contraindications Details
Meanwhile Etoricoxib Tab contraindicated in:
- Hypersensitivity to active substance or to any of the excipients.
- Active peptic ulceration or active gastrointestinal (GL) bleeding.
Berica (Etoricoxib) Tablet Pregnancy
Most importantly Etoricoxib contraindicated in pregnancy. However If a women become pregnant during treatment, it must discontinued.
Nursing Mother
In addition Women who sue the medicine must not breast feed. Meanwhile first consult your doctor or pharmacist.
Warnings & Precautions
Gastrointestinal Effects
Most importantly Caution advised with treatment of patients most at risk of developing a gastrointestinal complication with NSAID. However the elderly, patients using any other NSAID. Or anaphylactic acid concomitantly or patients with a prior history of gastrointestinal diseases such as ulceration and GL bleeding.
Gardiovascular Effects
Meanwhile Patients with significant risk factors for cardiovascular events. e.g. hypertension, hyperlipidemia, diabetes mellitus. On the other hand, smoking should only treated with this medicine after careful consideration.
Drug Interactions
Oral Anticoagulants
However Patients receiving chronic warfarin therapy, the administration of 120 mg daily associated with an increase in prothrombin time international normalized ratio(INR). Therefore patients receiving anticoagulants should closely monitored for their prothrombin time INR.
Overdosage Symptoms And Treatment
Symptoms:
Meanwhile The most frequently observed adverse experiences are consistent with the safely profile for this medication. Like, gastrointestinal events, cardio-renal events.
Treatment:
However, In the event of overdose, it is reasonable to employ the usual supportive measure e.g. remove unabsorbed material from the Gl tract. Meanwhile, emply clinical monitoring and institute supportive therapy, if required.
Etoricoxib is not dialyzable by hemodialysis. However, it is not known whether it is dialyzable by peritoneal dialysis.
Storage Instructions
Most importantly keep all the tablets, syrups, injections out of the reach of the children. On the other hand store the tablets at a cool and dry place. Meanwhile protect the tablets from direct sun light and heat.
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Berica (Etoricoxib) Tablets Price (Rs. 371 PKR)