Cycin Tablet (Ciprofloxacin HCL) 250 MG 500MG Injections
Cycin Tab contains Ciprofloxacin Hcl. Ciprofloxacin USP is a synthetic broad spectrum antibacterial agent for oral administration. The product is available as 500mg capsules and 250mg tablets as well as injections.
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Cycin Formula Ingredients & Composition
- Each film coated tablet contains Ciprofioxacin HCL(USP) 291 mg eq. to 250mg
- Each film coated tablet contains Ciprofloxacin HCL (USP)582mg eq to 500mg
All Microbiology Details Of Medicine
In -vitro studies indicate that the antibacterial action result from the inhibition of bacterial DNA gyrase. Moreover it is effective against the following types of gram negative and gram positive bacteria:
- E coil
- Shigella
- Proteus (indole+ and indole)
- Providencia
- Morganella
- Yersinia
- Vibrio
- Aeromonas
- Plesiomonas
- Pasteurella
- Haemophilus
- Gardnerlla
- Campylobacter
- Pseudomonas
- Legionella
- Neisseria
- Moraxella
- Acinetobacter
- Flavobacterium
- Alcaligenes
- Brucella
- Streptococcus
- Strep
- Faecalis
- Staphylococcus
- Listeria
- Corynebacterium
- Bacteroides
- Fusobacterium
- Peptostreptococcus
- Peptococcus
- Clostridium
- Eubacterium
- Actinomyces
- Veillonella
- Mycoplasma
- A few species of Mycobaterium
are generally less sensitive and should be tested before treatment
Clinical Pharmacology Information
Ciprofloxacin Tablets are rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute substantial loss by first pass metabolism maximum serum concentration are attained 1 to 2 hours after oral dosing .
Approximately 40 to 50 of an orally administration dose is excreted in the urine as unchanged widely distributed throughout the body .
The medicine present in active from in the saliva nasal. And bronchial secretions sputum skin blister fluid lymph peritoneal fluid bile and prostatic secretions.
It has also been detected in lung skin fat muscle cartilge and bone. The drug diffuses into the cerebrospinal fluid (CSF). However CSF concentration are generally less than 10% of peak serum concentrations.
Ciprofloxacin Tablets Cycin 250 MG 500 MG Injection Uses & Indication
Tab Ciprofloxacin HCL indicated for the treatment of infections caused by the sensitive pathogens
- Infections of the respiratory tract
- Infection of ear nose and throat
- Septicaemia
- Infection of mouth teeth and jaws
- Infection of the kidneys and or efferent urinary tract
- Meningitis
- Infection of the genital organs including gonorrhea
- Infection of the gastrointestinal tract
- Wound and soft tissue infection
- Infection of bones and joints
- Gynecological and obstetric infections
- Peritonitis
- Ophthalmological infections
Ciprofloxacin Tablet Injection Cycin Dosage And Administration
Firstly, the recommended initial dose is generally given to adults orally in a daily dose. On the other hand, Dose of Ciprofloxacin 250mg to Ciprofloxacin 500mg as equally divided dose into 2 times.
Meanwhile, the doses may be adjusted in patients with impaired renal function by administering half of normal dose. On the other hand, Cycin Tab dosage should be adjusted according to causative organisms and severity of symptoms.
Warnings & Precautions Details
Tendinitisor tendon rupture, particularly affecting the achilles tendon may occur. However, If there occur pain, inflammation, tendon rupture, the drug should discontinued. Until tendinitis or tendon rupture diagnosed definitely take a rest and avoid doing an exercise.
Medications Contraindications
- Firstly, patients with hypersensitivity to cycina.
- Secondly, its contraindicated in pregnant women during pregnancy and lactation.
- On the other hand, Children, adolescents
- Consequently, the Patients with hepatic disease
- In addition the Patients with a history of hypersensitivity, tendinitis, tendon rupture to quinolone class antimicrobial agent.
Ciprofloxacin Tablets Cycina Side Effects
Shock like Side Effects
Shock like symptoms rarely occur. Meanwhile, If such symptoms:
- Feeling Unwell
- Sweating
- Dyspnea
- Hypotension
However, the cases observed discontinue the medication and take appropriate treatments.
Side Effects On Skin
- Steve Johnson Syndrome
- Photosensitivity
- Flushing
- Fever
- Anaphylactic
These Ciprofloxacin side effects may appear in rare cases.
Hypersensitivity
- Rash or Pruritis
- Face Edema
- Throat Edema
Renal
Elevation of BUN and serum creatinine, acute renal failure, nephritis, crysaluria
Hepatic
Elevation of S-GOT, S-GPT, alkaline phosphatase, v-GTP or total bilirubin may infrequently occur.
Hematologic
Decrease in leucocytes, erythrocytes, hematocrit or platelets and increase in eosinophilic may infrequently occur.
Digestive
Nausea, vomiting, discomfort in stomach or abdomen, diarrhea, loose stool, anorexia, stomach ache, abdominal pain or heart burn may occur infrequently and thirst or stomatitis may appear rarely.
Psychoneurologic
In addition, Insomnia, dizziness or headache may infrequently occur and numbness may appear rarely.
Muscle
Consequently, Myalgia, asthemia, striated muscle sychysis attends increase in cpk, plasma and urine myoglobin.
Respiratory
Meanwhile, Intestitial pneumonia attended with fever, cough, dyspnea, chest x-ray abnormal, elevation of eosinophilia may occur.
Drug Interactions
- Its administration with theophylline may lead to elevated serum concentration.
- Convulsion has been reported with the concomitant use of this product with nonsteroidal anti-inflammatory phenyl acetic propionic acid derivative such as fenbufen.
- Antacids containing alumium or magnesium may interfere with the absorption of this medicine resulting in accumulation of the efficacy of cycina.
- Elevated serum levels of creatinine has been reported with concomitant use of cyclosporine with the medication.
Use During Pregnancy & Lactation
- Tablets in pregnancy has not been established. Therefore medicine should not be administered to patients who are or may become pregnant.
- Since it transfers to human milk. However, It is recommended refrain from lactation during the administration of this drug.
Use in Children
Since the safety in children has not been established. Therefore, it should not use in children.
Cycin Storage Instructions
Firstly, store the medications below 30 C. On the other hand, protect from sunlight and moisture. Lastly, and most importantly, you must always see the packing of medications to see its expiry date which always printed on the packing.
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Cycin Tab (Ciprofloxacin HCL) Tablets Capsules Injection Price (Rs. 400 PKR) and $ 8 USD in USA