Lanoxin (Digoxin) Tablets Injection Uses Dosage Side Effects Price

What is Lanoxin Tablets Injection, Best Time To Use It?

Lanoxin generic name is Digoxin which is the main active ingredient used in the medication. Meanwhile, Lanoxin Tablets & Injection considered a prototype cardiac glycoside, combine a steroid nucleus with an unsaturated five-membered lactone ring at the 17th position. And a series of sugar linked to carbon 3 of the nucleus. Which contain 3 molecules of digitoxin linked to digitoxigenin. Meanwhile, Digoxin is obtained from the leaves of Digitalis lanata. Furthermore, It is used for the treatment of heart failure and different types of heartbeat irregularities to perform heart function more effectively.

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The effects of the medicine basically work by helping the heartbeat to perform more effectively and also improving its ability to pump blood through vessels throughout the human body to maintain the body functions work properly. But as with all the other allopathic medications, you must also take this medicine exactly as your pharmacist or doctor may have told you because the exceeded dose may create several side effects and further complications to your health.

What Are Lanoxin Tablets Uses & Indications?

Lanoxin Tablets Injection uses for the management of chronic cardiac failure conditions or irregular heartbeat problems like atrial fibrillation. Where the dominant problem is systolic dysfunction. Its therapeutic benefit is those patients with ventricular dilatation. Moreover, it specifically indicated where cardiac failure is accompanied by atrial fibrillation. While this product is also indicated in the management of certain supraventricular arrhythmias, particularly chronic atrial and fibrillation. This medicine mechanism of action works by increasing the strength and efficiency of the heart contractions by improving the blood flow through human veins to all the body parts. But sometimes doctors and pharmacists may recommend its use with other medications in combination to get the desired results quickly. However, only your doctor or pharmacist may only have to decide whether use this medicine for you or not only after examining your symptoms and benefits and side effects.

How Much Lanoxin Tablets Dosage Should Used?

The general dose for each patient has to be tailored individually according to age, lean body weight and renal function. However, suggested doses are intended only as an initial guide. Meanwhile, the difference in bioavailability between Lanoxin Injection and Lanoxin Tablet oral formulations must be considered when changing from one to another. For example, if patients are switched from the oral to the injection intravenous formulation the dosage should be reduced by approximately 33.

250 MG, MCG Tablet For Adults And Children (over 10 years)

For Oral Use

• Adults With Chronic Cardiac Failure In The Absence Of Supraventricular Arrhythmias

No loading dose is required. The usual daily dose is 125 to 250 micrograms (0.125 to 0.25 mg) for patients with normal renal function. On the other hand, a lower dose of 62.5 micrograms (0.0625mg) should be considered for the older patients.

• For The Management Of Atrial Fibrillation Or Flutter.

Rapid oral loading If medically appropriate, rapid digitalization may be achieved in a number of ways, such as the following:

• It is recommended to use 750 to 1500 micrograms (0.75 to 1.5 mg) in a single dose. Furthermore, where there is less urgency or greater risk of toxicity. The oral loading dose should give in divided doses 6 hours apart and assessing clinical response before giving each additional dose.

Slow oral loading Meanwhile, In some patients with mild heart failure, the digitalization may be achieved more slowly with doses of 250 to 750 micrograms (0.25 to 0.75 mg) daily for one week. with following by an appropriate maintenance dosage. Generally, the clinical response must be seen within one week. However, the choice between slow and rapid oral loading depends on the clinical state of the patients and the urgency of the condition.

0.25 MG/1 ML Solution For Injection

• For Intravenous Use

Parenteral loading For use in patients who have not been cardiac glycosides within the preceding two weeks. The loading of parenteral 500 to 1000 micrograms (0.5 to 1.0 mg) depends on age, lean body weight and renal function. The loading dosage should be administered in divided with approximately half of the total dose given as the first dose. And further total dose is used in intervals of 4 to 8 hours.  An assessment of clinical response should be performed before giving each additional dose. Each dose should be given by intravenous infusion. Maintenance Dose (all formulations) The maintenance medicine dosage should be based on the percentage of the peak body stores lost each day through elimination. In practical studies, most patients with heart failure will maintain 125 to 250 micrograms (0.125 to 0.25 mg ) of medicine daily. However, in those who show increased sensitivity to the adverse effect of a dose of 62.5 micrograms (0.0625 mg ) daily or less may suffice. Conversely, some patients may require a higher dose

• Neonates, infants and children up to 10 years of age (if cardiac glycosides have not been given in the preceding two weeks).

If cardiac glycoside has been given in the two weeks preceding the commencement of digoxin therapy. It should anticipate that optimum loading doses of digxoin will less than those recommended below. Meanwhile, in newly born babies, renal clearance of the medicine is diminished and suitable dose reductions must be observed, over and above general dosage instructions. Beyond the immediate newborn period. Generally require proportionally increased doses than adults on the basis of body weight or body surface area. Children over 10 years of age require adult dosage in proportion to their body weight.

• Parenteral Loading

The parenteral loading dose in the above groups should be administered in accordance with the following schedule:

• Preterm neonates less than 1.5 kg          20 micrograms/kg over 24 hours.
• Preterm 1.5 kg to 2.5 kg                            30 micrograms/kg over 24 hours.
• Term neonates to 2 years                          35 micrograms /kg over 24 hours.
• 2 to 5 years                                                  35 micrograms/kg over 24 hours.
• 5 to 10 years                                                25 micrograms/ kg over 24 hours.

The loading medications dose should be administered in divided doses with approximately half the total dose given as the first dose. And further, these Tablets Injection doses of the total dose may use at intervals of 4 to 8 given by i.v infusion Oral loading dose This should  administered in accordance with the following schedule;

• Preterm neonates less than 1.5 kg           25 micrograms/kg per 24 hours.
• Preetem neonates 1.5 kg to 2.5 kg           30 micrograms /kg per 24 hours.
• Term neonates to 2 years                           45 micrograms /kg per 24 hours.
• 2 to 5 years                                                   35 micrograms /kg per 24 hours.
• 5 to 10 years                                                 25 micrograms /kg per 24 hours.

The loading dose should administered in divided doses with approximately half the total dose given as the first dose. And further fractions of the total dose were given at intervals of 4 to 8 hours, assessing clinical response before giving each additional dose.

Maintenance Dose

The maintenance dose should be administered in accordance with the following schedule ; Preterm neonates: daily dose 20 of 24 hours loading dose. Term neonate and children up to 10 years; daily dose =25/24 hours loading dose. Meanwhile, these dose schedules provide just guidelines and careful observation and monitoring of serum medicine levels should be used as a basis for adjustment of dosage in these paediatric patient groups.

Dose For Older Patients

Meanwhile, the tendency to impaired renal function and low lean body mass in older patients is the pharmacokinetics of Lanoxin. Such that high serum levels and associated toxicity can occur quite readily. Unless doses lower than those in nonelderly patients are used. Furthermore, the serum levels must check regularly and hypokalemia must be avoided.

Renal Impairment

A reduction in both initial and maintenance doses should be considered.

What Are The Contraindications For Its Use?

Mainly its contraindicated in patients known to be hypersensitive to digoxin, other digitalis glycosides, or any component of the preparation. In intermittent complete heart block or second-degree atrioventricular block. Especially if there is a history of Stokes-Adams attacks in any patient. Furthermore, the medication is contraindicated in arrhythmias caused by cardiac glycoside intoxication. On the other hand, It is also contraindicated in supraventricular arrhythmias associated with accessory atrioventricular characteristics of the accessory pathway. And any possible deleterious effect of digoxin on these characteristics has been evaluated. If an accessory pathway is known or suspected to be present. And there is no history of previous supraventricular arrhythmias, this medicine is similarly contraindicated. It is also contraindicated in ventricular tachycardia or ventricular fibrillation. The drug is also contraindicated in hypertrophic obstructive cardiomyopathy unless there is concomitant atria fibrillation and heart failure. But even then caution should be exercised if Digoxin is to be used.

What Are These Medicine Warnings And Precautions?

Arrhythmias may be precipitated by digoxin toxicity, some of which can resemble arrhythmias for which the lanoxin drug could be advised. In some cases, sinoatrial disorder (i.e.Sick Sinus Syndrome) may cause or exacerbate sinus bradycardia or cause a sinoatrial block. The administration of the medicine in the period immediately following myocardial infarction is not contraindicated. However, the use of inotropic drugs in some patients in this setting may result in an undesirable increase in myocardial oxygen demand. And ischaemia or some retrospective following studies have suggested Medicine to be associated with an increased risk of death. Treatment with the Durg should generally be avoided in patients with heart failure associated with cardiac amyloidosis. However, if alternative treatment with another drug is not appropriate, digoxin medicine can use with caution to control the ventripitate vasoconstriction. Therefore should avoid in patients with myocarditis. Furthermore, the patients of beri beri heart disease may fail to respond to the use of this medication. If the underlying thiamine deficiency is not treated concomitantly. There is also some published information indicating that medicine may inhibit the uptake of thiamine in myocytes in beri beri heart disease. It should not be used in constrictive pericarditis unless it is used to control the ventricular rate in atrial fibrillation or to improve systolic dysfunction. The drug improves exercise tolerance in patients with impaired left ventricular systolic dysfunction. And normal sinus rhythm. This may or may not associate with an improved haemodynamic profile.

• 250 Micrograms Tablets

Patients with malabsorption syndrome or gastrointestinal reconstructions may require larger doses of Digoxin Medicine.

• Lactose

Patients with hereditary problems of fructose or galactose intolerance the Lapp lactase deficiency. Or glucose-galactose malabsorption or sucrose isomaltase insufficiency should not take the medicine.

Is Lanoxin Tab Use Safe In Pregnancy?

The use of Laxonin (Digoxin) in pregnancy is not contraindicated. Although the Dosage may be less predictable in pregnant than in non-pregnant women some require an increased dosage of Lanoxin during Pregnancy. Adverse foetal effects have been reported in mothers with digitalis toxicity. Although it is excreted in breast milk the quantities are minute and breastfeeding not contraindicated.

How Much Lanoxin (Digoxin) Side Effects May Appear?

• Blood And Lymphatic System Disorders

Very Rare:                    Thrombocytopaenia

• Metabolism And Nutrition Disorders

Very Rare:                    Anorexia

• Psychiatric Disorders

Uncommon:                Depression Very Rare:                    Psychosis, Apathy, Confusion

• Nervous System Disorders

Common:                      CNS Disturbances, Dizziness Very Rare:                     Headache

• Eye Disorders

Common:                       Visual Disturbances, Blurred or yellow vision

• Cardiac Disorders

Commons:                       Arrhythmia, Conduction disturbances, Bigeminy, trigeminy, PR prolongation, Sinus bradycardia Very Rare:                     Supraventricular tachyarrhythmia, atrial tachycardia, junctional tachycardia, ventricular arrhythmia, ventricular premature contraction, ST Segment depression

• Gastro-Intestinal Disorder

Commons:                       Nausea, vomiting, diarrhoea Very Rare:                     Intestinal ischaemia, intestinal necrosis

• Skin And Subcutaneous Tissue Disorders

Commons:                       Skin Rashes of urticaria or scarlatiniform character may find by pronounced eosinophilia.

• Reproductive System And Breast Disorders

Very Rare:                     Gynaecomastia can occur with long-term administration.

• General Disorders And Administration Site Conditions

Very Rare:                     Fatigue, malaise, weakness

What Are Its Overdose Symptoms And Treatment?

Overdose with this medicine may cause some symptoms and signs to become more frequent with levels above 2.0 nanograms/ml. Although it is considerable inter-individual variation.

Adults

In adults without heart disease, clinical observances recommend that a Digoxin overdose of 10 mg to 15 mg can be destructive for 50% of patients. Cardiac manifestations can be the most regular and heavy sign of both acute and chronic toxicity of Digoxin Tablets or Injections. Peak cardiac side effects generally appear in 3 to 6 hours following an overdose and may stay for 24 hours or longer. Digoxin toxicity can generate almost any kind of arrhythmia, and studies have established that multiple rhythm irritations and disorders in the same patient are familiar. These can include paroxysmal atrial tachycardia with variable atrioventricular block, accelerated junctional rhythm, slow atrial fibrillation with slight variation in ventricular rate, and bi-directional ventricular tachycardia. Premature ventricular contractions are often the earlier and most typical arrhythmia. Bigeminy or trigeminy also appears continually. Sinus bradycardia and other bradyarrhythmias are typical. First, second, and third-degree heart blocks and AV dissociation are also expected. Early toxicity may only be displayed by prolongation of the PR intermission. Ventricular tachycardia may also be a manifestation of toxicity. Cardiac detention from asystole or ventricular fibrillation due to medication toxicity is usually destructive. Hypokalemia may contribute to toxicity. It’s important to get immediate medical attention if an overdose or toxicity is suspected.

• Children

In children aged 1 to 3 years without heart disease, clinical studies show that an overdose of 6 to 10 mg was the dose resulting in death in half of the patients. Most manifestations of toxicity in children occur during or shortly after the loading phase with Digoxin Medicine.

• Cardiac Manifestations

The same arrhythmias or combinations of arrhythmias that occur in adults can occur in children. Sinus tachycardia, supraventricular tachycardia, and rapid atrial fibrillation were seen less frequently in the paediatric population. Paediatric patients are more likely to be prescient with an AV conduction disturbance or sinus bradycardia. ventricular ectopy is less common. However, in massive overdose, ventricular ectopy, ventricular tachycardia and ventricular fibrillation have been reported. Any arrhythmia alteration in cardiac conduction that develops in a child taking it should assume to be caused by this until further evaluation proves otherwise. The frequent extracardiac manifestations are similar to those seen in adults gastrointestinal, CNS and visual. However, nausea and vomiting are not frequent in infants and small children.

• How To Treat Overdose Symptoms?

In cases of massive digitalis ingestion, it is recommended that patients receive large doses of activated charcoal. This helps to prevent the absorption of the substance and binds it in the gut during enteroenteric recirculation. Additionally, hypokalemia should be corrected. However, in cases where a large amount of LANOXIN has been ingested, hyperkalemia may be present due to the release of potassium from skeletal muscle. Before administering potassium in cases of LANOXIN overdose, it is essential to determine the serum potassium level. In adults without heart disease, ingestion of more than 25 mg of this medication can lead to death or progressive toxicity that may only respond to binding Fab antibody fragments. If a child aged 1 to 3 years without heart disease ingests more than 10 mg of Digoxin, the outcome is uniformly fatal when Fab fragments treatment is not given. Therefore, prompt medical attention should be sought in cases of digitalis overdose, and appropriate treatment measures should be taken to avoid severe consequences.

Lanoxin (Digoxin) Tablets Injection Storage Instructions

Most importantly, store Lanoxin (Digoxin) Tablets Injection below 25 C temperatures. On the other hand, also protect the drug from heat and sunlight. Furthermore, Do not freeze the medicine. In addition, you must remember to keep all your medical products out of the reach of your children at home.

 

What Is Lanoxin (Digoxin) Tablets, Injection Exact Price?

• Price In Pakistan: 285 PKR
• Price In India: 215 INR
• Price In UAE Dubai: 4 AED
• Price In USA: 2 USD