Fortum Injection 500mg 1G (Ceftazidime) Uses Dosage Details
Fortum Injection contains a very useful drug named Ceftazidime .Ciftazidime is a 3rd generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7 aminocephalosporic acid and closely related to penicillins in structure. Ceftazidime is important to take the drug for the full time period as prescribed.If it disconnected during the therapy, it may result in ineffective treatment.
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Fortum (Ceftazidazine) Injection Uses
The drug used for the treatment of single or multiple infections caused by susceptible organisms. It also may used alone as first choice drug before the results of sensitivity tests are available. Moreover it also used in combination with an aminoglycoside or most other beta lactam antibiotics. Also used with an antibiotic against anaerobes when the presence of Bacteroides fragilis is suspected. Indications includes.
Sever Infection Like
- Septicaemia, Bacteraemia, Peritonitis, Meningitis
- Infections in immunosuppressed patients
- Infections in patients in intensive care e.g. infected burns
Respiratory tract infections including lung infections in cystic fibrosis
- Ear, nose and throat infections
- Urinary tract infections
- Skin and soft tissue infections
- Gastrointestinal, biliary and abdominal infections
- Bone and joint infections
- Infections associated with haemo and peritoneal dialysis and with continuous ambulatory peritoneal dialysis (CAPD).
- Prophylaxis, prostatic surgery (Transurethral reaction)
Fortum Injection Dose And Administration
Mainly the dose of the medicine depends upon the severity, sensitivity site and type of infection and upon the age and renal function of the patient.
Use of I.V. or by deep I.m. Injection. Meanwhile, the recommended I.M. inj sites advice the upper outer quadrant of the gluteus maximus or lateral part of the thigh. On the other hand, Fortum solutions may use directly into the vein or introduced into the tubing of a giving set if the patient is receiving parenteral fluids.
Dosage For Adults
1 to 6 g/day in two or three divided doses by i.v. or i.m. inj.
Dose For Urinary tract and less severe infections:
500 mg or 1 g every 12 hours
Most Infections
1 g every 8 hr or 2 g every 12 h.
Very Severe Infections Particularly In Immunocompromised Patients Including Those With Neutropenia:
The Injection 2 g every eight of 12 hr or 3 g every 12 hr.
Fibrocystic Adults With Pseudomonal Lung Infections
Ceftazidime Inj 100 to 150 mg/kg/day in three divided doses.
However, In adults in the normal renal function 9 g/day use without ill effect. But, when used as a prophylactic agent in prostatic surgery it should be use 1 g given at the induction of anaesthesia. Meanwhile, second dose should be considered at the time of catheter removal.
Dose For Infants And Children (Over Than 2 Months)
30 to 100 mg/kg/day in two or three divided doses.Doses up to 150 mg/kg/day (maximum 6 g/day) in three divided doses may be given to infected immunocompromised or fibrocystic children or children with meningitis.
Neonates (0 to 2 months)
25to 60 mg/kg/day in two divided doses. in neonates the serum half life of the medicine can be three to four times taht in adults.
Dose For Elderly
Meanwhile, In view of the reduced clearance of this medication in severe ill elderly patients. The daily Fortum Injection dosage should not normally exceed 3 g, especially in those over 80 years of age.
Dosage In Renal Impairment
Ceftazidime Injection is excerted unchanged by the kidneys. Therefore in patients with impaired renal function the dosage should reduced. And initial loading dose of Fortum 1 g should given. Maintenance doses should monitored and trough levels should not exceed 40 mg/l. In the children the creatinine clearance should adjusted for body surface area or lean body mass.
Dose For Haemodialysis
The serum half life during haemodialysis ranges from 3 to 5 h.. Following each haemodialysis period the maintenance dose of the inj solution recommended in the above table should repeated.
Dose For Peritoneal Dialysis
It may used in peritoneal dialysis and continuous ambulatory peritoneal dialysis (CAPD). In addition to i.v. use it can incorporated into the dialysis fluid (usually 125 to 250 mg for 2 liters of dialysis solution).
Fortum Injection Contraindications
- Patients with known hypersensitivity to cephalosporin antibiotics.
- On the other hand, Hypersensitivity to the medication pentahydrate or to any of the ingredients of the product
Warning And Precautions Details
Meanwhile, before the beginning of the treatment establish whether the patient has a history of hypersensitivity reactions to ceftazidime, cephalosporins, penicillins or other drug. So therefore, Special care is indicated in patients who have experienced an allergic reaction to pencillins or other beta lactams. However, If an allergic reaction to Fortum Medicine occurs discontinue the drug. Meanwhile, serious hypersensitivity reactions may required epinephrine (adrenaline), hydrocortisone, antihistamine or other emergency measure.
Drug Interactions Information
Concurrent use of high doses with nephrotoxic drugs may adversely affect renal function. Meanwhile, Chloramphenicol is antagonistic in vitro with ceftazidime and other different cephalosporins. However, the clinical relevance of this finding also unknown. But if concurrent administration of Fortum Injection Drug with chloramphenicol proposed then there is the possibility of antagonism should considered. However, normally with other various antibiotics, it may affect the gut flors, leading to lower oestrogen reabsorption and it also reduce the efficacy of combined oral contraceptives. Furthermore, the inj not interfere with enzyme based tests for glycosuria. But slight interference may occur with copper reduction methods (Benedict’s, Fehling’s, Clinitest). And consequently, it also does not interfere in the alkaline picrate assay for creatinine.
Fortum Injection (Ceftazidime) Side Effects
Infections And Infestations
Uncommon: Candidiasis (including vaginitis and oral thrush
Blood And Lymphatic System Disorders
Common: Eosinophilia and thrombocytosis
Uncommon: Leucopenia, Neutropenia And Thrombocytopenia
Very Rare: Lymphocytosis, Haemolytic anaemia, and Agranulocytosis
Immune System Disorders
Very Rare: Anaphylaxis (including bronchospasm or hypotension)
Nervous System Disorders
Uncommon: Headache, Dizziness
Very Rare: Paraesthesia
Vascular Disorders
Common: Phlebitis or thrombophlebitis with i.v. administration
Gastrointestinal Disorders
Common: Diarrhoea
Uncommon: Nausea, Vomiting, Abdominal pain, Colitis
Very Rare: Bad Taste
However, As with other cephalosporins, colitis may associated with Clostridium difficile and may present as pseudomembranous colitis.
Hepatobiliary Disorders
Common: Meanwhile, Transient elevations in one or more for the hepatic enzymes. Which includes ALT (SGPT), AST (SOGT), LDH, GGT and alkaline phosphatase.
Very Rare: Jaudice
Skin And Subcutaneous Tissue Disorders
Commmon: Maculopapular or urticarial rash
Uncommon: Pruritus
Very Rare: Angioedema, erythema multiforme, Stevens Johnson Syndrome and toxic epidermal necrolysis.
General Disorders And Administration Site Conditions
Common: Pain and inflammation after i.m. inj
Uncommon: Fever
Investigations
Common: Positive Coombs test
Uncommon: However, As with some other cephalosporins, transient elevations of blood urea, blood urea nitrogen and serum creatinine have been observed. Meanwhile, the positive Coombs test develops in about 5% of patients which may interfere with blood cross-matching.
Overdosage Symptoms & Treatment Guide
The overdosage with this product can lead to neurological sequelae including encephalopathy, convulsions and coma. Furthermore, Serum levels of this medication can reduced by haemodialysis or peritoneal dialysis.
Drug Storage Instructions
In conclusion, Store Fortum Drug below 25 C temperature. On the other hand, Protect the medicine from sunlight and heat. Furthermore, always remember to keep all the medicines out of the reach of the children.
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Fortum Injection (Ceftazidime) Price (Rs. 399 PKR)