Hitop Tablets (Topiramate) 25 MG 50 MG Uses Dosage Details
Hitop Tablet contains a very useful medicine named Topiramate. It is a sulfamate substituted monosaccharide an anti-epileptic drug. Topiramate products its anticonvulsant activity through its three actions.
- Weakly inhibits stimulatory action of kainite, AMPA subtype of glutamate receptor.
- Decrease the number of action potentials produced in case of sustained neuronal depolarization.
- Gaba increased activity at some type of GABA Receptors.
Composition, Formula & Ingredients
- 25mg : Each Tablet Contains: Topiramate U.S.P………….25 mg
- 50 mg : Each Tablet Contains: Topiramate U.S.P ………..50 mg
Hitop Tablet 25MG 50 MG Uses Information
Epilepsy: initial monotherapy inpatient > 2 years of age with partial-onset or primary generalized tonic-clonic seizures.
Hitop is recommended as adjunctive therapy for adults and children ( 2 to 16 years) suffering from partial-onset seizures or primary eneralized tonic-clonic seizures, and for patient >2 years of age with seizures associated with Lennox Gastaut syndrome Migraine.
Topiramate indicated for patient > 12 years of age for prophylaxis of migraine headaches.
Contraindications Of This Medicine
Hypersensitivity to any ingredient of this medicine.
Hitop Tablets Dosage & Administration
Therapy with Hitop should start at a low dose and then up titrated tot he target dose. Hiptop can take irrespective of the meal.
Dosage In Monotherapy in Epilepsy
The recommended dosage for monotherapy in adults and pediatric patients 10 years and older is 400 mg/day in two divided doses. However, the scheduled dose must be
- First Week 25 MG In Morning 25 MG In Evening
- Second Week 50 MG In Morning 50 MG In Evening
- Third Week 75 MG In Morning 75 MG In Evening
- Fourth Week 100 MG In Morning 100 MG In Evening
- Fifth Week 150 MG In Morning 150 MG In Evening
- Sixth Week 200 MG In Morning 200 MG In Evening
Furthermore, the dose in Pediatric patients from 2 to 9 years in Epilepsy: initial dose is 25 mg/day nighly for first week. Based upon tolerability dosage can be increased to 50 mg/day (25 mg twice daily) in the second week.
Dosage In Adjunctive Therapy Epilepsy
Adults (17 Years Of Age And Over)
Adjunctive therapy in adults with partial-onset seizures or Lennox gastaut syndrome is 200 to 400 mg/day in two divided doses. And 400 mg/day in two divided doses as adjunctive treatment in adults with primary generalized tonic-clonic seizures.
Pediatric Patients From 2 To 16 Year Age
The recommended dose of Topiramate as adjunctive therapy for pediatric patients 2 to 16 years of age with partial-onset seizures, primary generalized tonic-clonic seizures. Or seizures associated with Lennox Gastaut syndrome is approximately 5 to 9 mg/kg/day in two divided doses.
Dosing In Migraine Prophylaxis
The recommended total daily dose of the medicine as a treatment for patients 12 years of age and older for prophylaxis of migraine headache is 100 mg daily administered in two doses divided doses.
Hitop Medicine Side effects
The most common side effects seen in adults with Topiramate are somnolence, fatigue, nervousness, psychomotor slowing, paraesthesia, ataxia, dizziness, taste perversion, difficulty with memory, confusion, speech disorders speech problems, difficulty with concentration. With a decrease, anorexia, nausea, abnormal vision, nystagmus, depression, language problems, tremor, mood problems, abdominal pain, dyspepsia, rhinitis, and pharyngitis.
Most common side effect seen in children are somnolence anorexia, fatigue, nervous, injury, personality changes difficulty, with concentration aggressive reaction weight decrease, insomnia, abnormal gait; purpura mood, problems increased salivation, nausea, pneumonia, hyperkinesis, confusion, dizziness, speech psychomotor slowing, and paraesthesia.
Few cases of thromboembolic events have been seen through their causal relationship with it is not proven.
Warnings & Precautions
Topiramate like other antiepileptic drugs should be slowly withdrawn to minimize the frequency of the seizures. In some clinical trials on adults patient, it was withdrawn at the rate of 100mg/day every week. In some patient withdraw can be done at a faster rate without any complication.
Patients with moderate or severe renal important may take 10 to 15 days to reach steady-state plasma concentration as compared to 4 to 8 days of inpatient normal renal function. The medication should titrated with the objective of achieving optimal seizures control and side effects avoidance.
There might be an increased risk for renal stone formation, especially in those who have a tendency towards nephrolithiasis. Or who exposed to risk factors like a family history of during formation treatment.
In hepatic dysfusi, Hitop should administer with caution since in this condition clearance of the medication may reduced.
Hitop Tablet Use in pregnancy
Studies have not conducted on topiramate use in pregnant women. Hence, safety in pregnancy has not established. Some cases of hypospadias have reported in males of infants who exposed to it in utero, alone or combined with other anticonvulsants. However, a causal relationship of this complication with this tab not proven. Use in lactating. women. Execration of this medicine treatment.
Effects on driving ability and use of machinery:
It may cause drowsiness, dizziness, or other related symptoms, Hence, caution advised when driving or operating machinery.
Overdose Symptoms & Treatment
First of all, If overdose with Topiramate acute i.e. recent, the stomach should immediately email through gastric lavage or emesis. Therefore, Appropriate supportive measures should undertake as required. In addition, the drug can effectively remove from the body through hemodialysis if the dose exceeds 20 mg.
Drug Interactions Of This Medicine
In general, it combined with other antiantiepileptic drugs like phenytoin, carbamazepine, valproic acid, phenobarbital, and primidone cause no effect on their steady-state plasma concentrations. Occasionally, there may be an increase in plasma concentration of phenytoin possibly due to inhibition of a specific enzyme polymorphic isoform (CYP2Cmeph). Hence, phenytoin serum concentration monitoring should be done inpatient on phenytoin plus topiramate.
However, A decrease in plasma concentration of this medication when phenytoin or carbamazepine co-administered with it. Hence, in case of the addition of discontinuation of phenytoin or carbamazepine in patients already on its therapy. The patient may need re-adjustment in the dose of Topiramate to the point of optimal seizure control. Therefore, Co-administration of vatroic acid does not cause any clinically significant change in the plasma concentration of the capsules. Hence ther is no need to adjust the dose of drug when co-administered with valproic acid.
Furthermore, the Concomitant use of Topiramate causes a significant increase in the plasma clearance of the oestrogenic component. Hence, the patient should use a preparation containing not less than 50 kg micrograms of estrogen some other alternative including non-hormonal method of contraception. If a patient taking oral contraceptives notice any change in their pattern. So, most importantly, they should report it to the doctor or physician.
Simulate administered of the medicine with Dixon cause a decrease in serum concentration of digoxin. Hence serum concentration of digoxin should carefully monitored, such patients.
Full Storage Instruction For The Medicine
First of all you must keep all your medicines out of the reach of your kids on safe place to protect their lives. Secondly, store the medicine in a cool but dry place below 30 C temperature. Furthermore, also protect the tablets from direct sunlight and heat exposure.
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