What Are Tramal Plus 50 MG 100 MG Tablets Tramadol Capsules Injections & Its Uses Dosage Side Effects?
Tramal Tablets contains Tramadol HCL which is centrally acting analgesic with a unique, dual mechanism of action with the CNS. Therefore, Tramal Plus Capsules become effective in the control of post operative pain in humans as well as in animals like dogs. But it is suitable as an adjunct to anesthesia because of low sedative properties it has.
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What Is Tramadol And What It Used For?
Tramadol Hydrochloride is mainly an opioid medication used for the treatment of severe to moderate pains in humans as well as animals like dogs cats etc. When used the medicine the mechanism of action with analgesic effects so fast that it immediately start working and you will get relief of pains within one hour. It mainly sold under the brand names of Ralivia, Tramal Tablet, Ultram and Zytram etc. It first found in Germany in year 1963. Meanwhile first approved to use in medicines in United Kingdom and USA in year 1990.
Tramal Tablets Composition Formula Ingredients
- Capsule Of: Each Capsule contains 50 mg of Tramadol Hydrochloride Ph. Eur.
- Tablet SR: Each Tablet Sustained Release film coated tablet contains 100 mg of Tramadol Hydrochloride PH. Eur. The chemical designation is (1 RS: 2 RS)-2-(Dimethylaminomethyl)-1-(Methoxyphenyl)-Cyclohexanol-Hydrochloride.
Uses In Urdu Hindi
Tramal Plus Tramadol Tablets Dosage
The Drug Dose should be adjusted to the intensity of the pain and the sensitivity of the individual patients. The lowest effective dose for analgesia should generally be selected. The total daily Tramadol Dose of 400 mg should not be exceeded, except in special clinical circumstances unless otherwise prescribed. This medicine should be administered as follow:
Adult And Adolescent Above The Age Of 12 Years
Tramal Capsule: 50 -100 Tramadol Hydrochloride 4-6 hours daily .
The usual initial Tramadol Hydrochloride Dose 50-100 mg twice daily, morning and evening. If pain relief is insufficient the dosage may be titrated upwards to 150 mg or 200 mg twice daily .
Pediatric Population
On account of Tamadol Plus Capsule high dosage strength and SR tablets not intended for children below the age of 12 years.
Elderly Population
The Drug Dosage adjustment is not usually necessary in patients up to 75 years without clinical manifest hepatic or renal insufficiency. In elderly patients over 75 years elimination may prolonged. Therefore, if necessary the dosage interval to extended according to the patients requirements.
Patients with Renal insufficiency Dialysis Hepatic impaiment
In patients with renal and hepatic insufficiency the elimination of this medicine delayed. In these patients prolongation of the dosage intervals should carefully considered according to the patients requirements.
Tramal SR Tablets
In case of severe renal and severe hepatic insufficiency with this medicine prolonged release tablets not recommended .
Tablets Used For The Duration Upto
It should under no circumstances be administration for longer than absolutely necessary. If long term pain treatment with Drug is necessary in view of the nature and severity of the illness. Then careful and regular monitoring should be carried out to establish whether and to what extend further treatment is necessary.
Tramal Plus Tramadol Tablets Capsules Uses & Indications
What is 50mg used for? So the answer is that, This Drug Tramal (Tramadol) Tablets 50 MG used and Indicated for Moderate to Severe pain .
Tramal Plus Tramadol Tablets Capsules Injections Contraindication
Tramadol HCL must not be administered in known hypersensitivity towards the medicine or any of the excipients or in acute intoxication with alcohol, hypnotic analgesics or other CNS acting drugs. Therefore, the medication must not be used for narcotic withdrawal treatment. On the other hand, Tablets must be used with special care in opioid dependence, reduced level of consciousness of unclear origin, disorder of the respiratory center of function, increased intracranial pressure. It must not be use in patients with epilepsy not adequately controlled by treatment. This medicine must not be used in patients who receiving MAO inhibitors or who have taken then within the last 14 days.
Tablets Capsules Injections Warning Precautions
Tramadol Hydrochloride 50 MG Tablets And Capsules may only be used after careful consideration of the benefit ratio and relevant precautions in dependence on opioids:
- Consciousness disorders of uncertain origin shock .
- Disorders of the respiratory center of function.
- Increased intracranial pressure due to head injuries or brain diseases .
Most importantly, If patients sensitive to opiates the medicine product should only be used with caution. Meanwhile, Convulsions have been reported in patients receiving this medicine at the recommended dose levels. Therefore, The risk may be increased when Tramadol Doses exceed the recommended upper daily dose limit 400 mg. In addition such medicine may increased the seizure risk in patients taking other medicine that lowers the seizure threshold. On the other hand, Patients with epilepsy or those susceptible to seizures should only be treated with it if there compelling circumstance. Meanwhile, it has a low dependence potential. So, On long term use psychic and physical dependence may develop. On the other hand, In patients with a tendency to drug abuse or dependence, treatment with this should only be carried out for short periods under strict medical supervision.
Tramadol HCL 50 MG Tablet not suitable as a substitute in opioip dependent patients. Although medicine is an opiate agonist, it cannot suppress morphine withdrawal symptoms.
Use In Pregnancy And Lactation
There inadequate evidence available on safety of medicine in human pregnancy. Therefore, the tablets should not used in pregnancy. On the other hand, 50 MG Tabs Caps passes the placental barrier and withdrawal symptoms may occur in the neonate due to habituation. Meanwhile, When given before or during birth the dose not affect uterine contractility. Therefore, In neonates it may induce changes in the respiratory rate which usually not clinically relevant. So, Only very small quantities of this medication (Approx. 0.1/ of an I.v dosage) excreted in the breast milk. Therefore, the medicine should not used during lactation. Meanwhile, After a single administration of its not usually necessary to interrupt breast feeding .
Tramal Plus Tramadol Capsules Tablets Injections Side Effects
Frequently nausea and dizziness have reported. Meanwhile, Occasionally Tramal (Tramadol) Tablets Side Effects like
- Vomiting
- Constipation
- Sweating
- Dry mouth
- Headache
- Dizziness may occur
However, In rare cases there may be effects on cardiovascular regulation
- Palpitation
- Tachycardia
- Postural hypotension
- Cardiovascular Collapes
Most importantly, These un usual effects may occur especially on intravenous administration and in patients who physically stressed. On the other hand, Gastrointestinal irritation (a feeling of pressure in the stomach ,bloating) and dermal reactions Like (Pruritus, rash ,urticaria ) may occur in rare cases.
In other side effects of this medicine includes
- Motor Weakness
- Changes in Appetite
- Micturition Disorders
- Usually Elation
- Occasionally dysphasia
- Suppression
- Changes in cognitive and sensorial capacity
- Decision behavior
- Perception disorders
- Allergic Reactions
- Dyspnea
- Bronochospasm
- Wheezing
- Angioneurotic Edema
- Anaphylaxis
- Worsening of Asthma
- Epileptiform Convulsions
- Respiratory depression
- Agitation
- Anxiety
- Nervousness
- Insomnia
- Hyperkinesia
- Tremor
- Gastrointestinal Symptoms
- Increase in live enzyme values
- Panic Attacs
- Severe anxiety
- Hallucination paresthesia
- Tinnitus
- Unusual CNS Symptoms
Effects On Driving And Machine Operators
Even when used according to instructions Tramadol HCL Tablets effects reaction to such an extent that road safety. However, The operation of machinery and working without a firm hold may impaired. Meanwhile, This applies particularly when starting treatment switching from other medicine products in conjunction with other centrally acting drugs and in particular with alcohol.
Tramal SR Plus Tablet Capsules Injections Drug Interactions
On pre-medication with MAO inhibitors in the last 14 days prior to the use of the opioid pethidine, life threatening interaction on the central nervous system. And respiratory and cardiovascular function have also observed. Meanwhile, The same Drug Interactions with MAO inhibitors and tabs cannot excluded.
Concomitant administration of this medication with other centrally depressant substance including alcohol may potentiate the CNS effects. Meanwhile, In Isolated cases there have reports of serotonin syndrome in a temporal connection with the therapeutic use of the medicine in combination with other serotoninergic medicinal products such as selective serotonin re uptake inhibitors (SSRI’s) or with MAO inhibitors. Signs of serotonin syndrome may for example
- Confusion
- Agitation
- Fever
- Sweating
- Ataxia
- Hyper Reflexia
- Myoclonus
- Diarrhea
More Interactions
Withdrawal of the serotoninergic medicinal products usually brings about a rapid improvement. Meanwhile, the medication depends on the nature and severity of the symptoms. And it may induce convulsion and increase the potential of selective serotonin reuptake inhibitors, tricyclic anti depressants, neuroleptics and other seizure threshold lowering to cause convulsion.
Meanwhile, The results of pharmacokinetic studies have so far shown that on the concomitant or previous administration of cimetidine clinically relevant interactions unlikely to occur. On the other hand, Simultaneous or previous administration of carbamazepine may reduce the analgesic effect and shorten the duration of action. The combination with mixed agonist antagonists.
Other drugs known to inhibit CYP3A4 such as ketoconazole and erythromycin. Might inhibit the metabolism of the medicine possibly also the metabolism of the active O-demethylated metabolite. The clinical importance of such an interaction has not studied. Caution should exercised during concomitant treatment with this. And coumarin derivatives due to reports of increased INR with major bleeding and ecchymosis in some patients. So, if you using any of the ingredients told here you must first discuss it with your doctor to avoid any kind of effects.
Tramal (Tramadol) Tablets Over dosage
Overdose Symptoms:
In principle on intoxication with Tramadol symptoms similar to those of other centrally acting analgesics (opioids ). Expected in particular
- Miosis
- Vomiting
- Cardiovascular collapse
- Reduced levels of consciousness up to coma
- Convulsions
- Respiratory depression up to respiratory arrest.
Overdose Treatment:
Meanwhile, The general emergency measures to keep open the respiratory tract (aspiration) maintenance of respiration And circulation depending on the symptoms apply. An antidote for respiratory depression naloxone. However, In animal studies naloxone had no effect on convulsions. In such cases diazepam should given I.V. However, in any case of overdosage you must first contact your doctor and reach to the near hospital for further treatment.
Tramal 50 100 Plus Tramadol Injection Capsules Tablets Storage Guide
Most importantly Protect the Tramadol Tab from moisture, heat and sunlight. Meanwhile always keep all the medical products from the children. On the other hand store it below 30 C temperature. Lastly, you must look the pack for an expiry date and if this product expired do not use it because it may become a threat to life.
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Tramal 50 MG 100 MG Tramadol Plus Injection Capsules Tablets Price Details
- Price In Pakistan= 250 PKR
- Price In India= 225 INR
- Price In USA= 4 USD