Atorva Tablets (Atorvastatin Medicine) 10 MG, 20 MG, 40 MG Uses Dosage Details
Atorva Tablets (Atorvastatin Medicine) is a selective competitive inhibitor of HMG- CoA reductase. The rate-limiting enzyme is responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonic a pressures of sterols including cholesterol. This Medicine lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of uptake and catabolism of LDL.
Composition Ingredients Formula
- Each 5MG Tablet Contains: Atorvastatin 5 MG Medicine (As Calcium Trihydrate Salt)
- 10 MG Each Tablet Contains: Atorvastatin 10 MG Medicine (as Calcium Trihydrate Salt)
- Each 20 MG Tablets Contains: Atorvastatin 20 MG Medicine (As Calcium Trihydrate Salt)
- Each 40 MG Tablet Contains: Atorvastatin 40 MG Medicine (As Calcium Trihydrate Salt)
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Atorva Atorvastatin Medicine Uses
Atorva 10 MG & 20 MG Tablets Atorvastatin Medicine is used and indicated as an adjunct to diet for the reduction of elevated cholesterol
- LDL-cholesterol
- Apoli-poprotein B
- Triglycerides
And to increase HDL- cholesterol in patients with primary, heterozygous familial. And non-familial hypercholesterolemia, and combined hyperlipidemia (Fredrickson types lla and llb).
It generally indicated as an adjunct to diet for the treatment of patients with elevated serum triglyceride levels, (Fredrickson type IV), and for the treatment of patients with dysbetalipoproteinemia(free-drickson type III) who do not respond adequately to diet. Moreover it is also indicated for the reduction of total cholesterol and LDL- cholesterol in patient with homozygous familial hypercholesterolemia when the response to diet and other non-pharmacological measures are inadequate.
Atorva Medicine Contraindications
Generally this medicine is contraindicated in patients who are hypersensitive to any component of this medication. So, who has active liver disease or unexplained persistent elevation of serum transaminases exceeding three times the upper limit of normal,
- Who are pregnant
- Who are breastfeeding
- In women of childbearing potential who are not using adequate contraceptive measures?
It should be administered to women of childbearing only when such patients are highly unlikely to conceive and have been informed of the potential hazards to the fetus.
Atorva (10MG, 20MG, 40MG) Tablets Dosage
The patient should place on a standard cholesterol-lowering diet before receiving this medication and should continue the diet during treatment with it. The usual starting dosage 10 mg to 80 mg once a day. The dosage range 10 to 80 mg once daily. The dose may give at any time of the day with or without food. Dosage should individualize according to baseline LDL-levels, the goal of therapy, and patient response.
Atorva Tablets Side Effects
Generally this is a well tolerated medication for all ages. Adverse reactions have usually been mild and transient. The most frequent were constipation, flatulence, dyspepsia, abdominal pain, headache, nausea, myalgia, asthenia, diarrhea, and insomnia.
Drug Precautions & Warnings
Hepatic effect as with other lipid-lowering agents of the same class. Moderate (>3* upper limit of the normal election of serum transaminases have reported following therapy with this drug. Liver function tests should perform before the initiation of treatment and periodically thereafter. Patients who develop increased transaminase levels should monitor until the abnormally. Should an increase in alt or ast of greater than three times the upper limit of normal persists, reduction of dose or withdraw of the medication recommended.
Atorvastatin Tablets Use In Pregnancy And Lactation
The drug contraindicated in pregnancy and while breastfeeding. Meanwhile, the women of childbearing potential should use adequate contraceptive measures. Meanwhile it administered to women of childbearing age only when such patients are highly unlikely to conceive and have informed of the potential hazards to the fetus. Not known whether this drug excreted in human milk. Because of the potential for adverse reactions in nursing infants, women taking the medicine should not breastfeed.
Drug Interaction Information
Firstly, the risk of myopathy during treatment with drugs in this class increased with concurrent administration of cyclosporine, fibric, acid, derivatives, erythromycin, azole antifungals, or niacin.
Antipyrine: Co administration of this medicine with an oral antacid suspension containing magnesium and aluminum hydroxides, decreased, atorvastatin, plasma, concentration approximately 35% however, LDL, the reduction not altered.
Digoxin:
When multiple doses of digoxin and 10 mg capsules co-administered, steady-state plasma digoxin concentration unaffected. However, digoxin concentration increased by approximately 20% following administration of digoxin with 80 mg medication daily.
Azithromycin:
Co administration of this medication (10 mg QD) and azithromycin (500 mg QD) did not alter the plasma concentration of it.
Cimetidine: Its interaction studies with cimetidine conducted, and no clinically significant interaction studied.
Other concomitant Therapy_ In clinical studies, this medicine used concomitantly with antihypertensive agents and estrogen replacement therapy without evidence of clinically significant adverse interaction.
Atorva (Atorvastatin) Medicine Overdosage Symptoms & Treatment
There is no specific treatment for its overdose. Most importantly, if an overdose occur, the patient treated symptomatically and supportive measures instituted, as required. So, due to extensive drug binding to plasma proteins, hemodialysis not expected to significantly enhance its clearance.
Atorva Tablets Storage Instructions
First of all keep all your medicines out of the reach of the small kids at home. On the other hand, store your medicine below 25C temperature. Also, protect your drugs from direct sunlight and heat exposure.
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Atorva (Atorvastatin) 5 MG, 10 MG, 20 MG, 40 MG Tablets Price