Nise Tablets (Nimesulide) 100 MG Uses Dosage Side Effects Price Details

What Is Nise Tablets 100 MG And What Are Its Uses Dosage Side Effects?

Nise Tablets 100 MG basically is the formulation of Nimesulide which is a very well known and useful effective NSAID. It reported to be selective inhibitor of cyclo oxygenase-2(COX-2). Furthermore, it used for inflammatory conditions, fever and pain.

More Useful Links:  Gutcare Sachet Tablet Uses, Dosage, Side Effects Benefits Formula Ingredients Price

Composition Ingredients & Formula Contains

• Each 100MG Tablet contains     :     Nimesulide B.P. = 100 MG

Uses In Urdu Hindi

Tab Mechanism Of Action

Nimesulide characterized by a unique multifactorial mode of action which targets a number of key mediators of the inflammatory process. On the other hand, this tab is also able to inhibit cyclo-oxygenase, the enzyme responsible for the synthesis of prostaglansin. Meanwhile, Both in vitro and in-vivo, it showed to inhibit preferentially the cox-2 enzyme. Which expressed during inflammation, with a minimal activity against Cox-1. Further, it plays a protective role in the gastric mucosa. Consequently, the medicine has demonstrated many other pharmacological effects that the basis for its clinical activities.

• Inhibition of phosphodiesterase (PDE)type lV
• Reduced generation of superoxide anion (02)
• Inhibition of proteases (elastase, proteinase)
• Scavenging of hypochlorous acid
• Inhibition of histamine release from human basophil and mast cells
• Inhibition of histamine activity
• Activation of glucorticoid receptor (GR) system
• Inhibition of the synthesis and release of the substance P(SP)

However, Inflammation a complex and multimediated process and as medicine shows a multifactorial mode of action the intensity of this can reduced in a particularly effective way. Most importantly, it is a unique NSAID, not only due to its chemical structure. But also because of its specific affinity to inhibit cycloxygenase-2. Thus exerting milder effects on the gastrointestinal mucosa. Furthermore, the medicine is able to affect all the mediators of pain and inflammation and has a desired and long lasting analgesic and anti-pyretic effect. In addition, Nimesulide inhibitd COX-1 to some extent; leading to better treatment of inflammatory pain. On the other hand, the capsules also reduces pain at central level through a spinal and supraspinal mechanism.  

What Are Nise Tablets Uses & Indications?

Tab NISE (Nimesulide) 100 MG Tablets indicated for the treatment of:

• Treatment of acute pain, including painful conditions associated with inflammation such as post-operative dental pain, post-surgical pain, post-traumatic conditions (acute joint and soft tissue injuries), painful extra-articular disorders, acute bursitis, tendinitis etc.
• Primary dysmenorrhea.
• Toothache

Nise Tablets Dosage And Administration

• Dosage For Adults

Usual oral Nise Tab dose of nimesulide 100 mg twice daily, for no more than 15 days.

• Dosage Adjustment And Dosing Consideration In Special Populations
• Children(<12 years)

Its contraindicated in children below 12 years and in patients suffering from liver problems.

• Adolescents (from 12 to 18 years)

On the basis of the kinetic profile in adults and on the pharmacodynamics characteristics of the medication, no Nise Tablet Dose adjustment in these patients in necessary.

• Elderly

No dosage adjustment required in the elderly.

• Dosage For Renal Impairment

On the basis of pharmacokinetics, no dosage adjustment is necessary in patients with mild to moderate renal impairment (creatinine clearance of 30-80 ml/min), Meanwhile its  contraindicated in case of severe renal impairment (creatinine clearance < 30ml/min).

• Hepatic Impairment

The use of Nimesulide contraindicated in patients with hepatic impairment.

Contraindications Details

• Hypersensitivity to nimesulide.
• History of hypersensitivity reactions (e.g. bronchospasm, rhinitis, urticarial, nasal polyps) in response to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs
• history of hepatotoxic reactions to nimesulide
• concomitant exposure to other potentially hepatotoxic substances,
• Alcoholism, drug addiction
• Cerebrovascular bleeding or other active bleeding or bleeding disorders
• Severe coagulation disorders
• Hepatic Impairment
• Severe heart failure
• Severe renal impairment
• Patients with fever and/or flu-like symptoms
• Children under 12 years
• The third trimester of pregnancy and breast feeding

Active gastric or duodenal ulcer, a history of recurrent ulceration or gastrointestinal bleeding

Warnings And Precaution 

• Rarely it has been reported to be associated with serious hepatic reactions, including very rare fatal cases. Patients who experience symptoms compatible with hepatic injury during treatment with this medication (e.g. anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine) or patients who develop abnormal liver function tests should have treatment discontinued. These patients should not be challenged with nimesulide. Liver damage, in most cases reversible, has been reported following short exposure to the drug.
• Concomitant administration with known hepatotoxic drugs, and alcohol abuse must be avoided during treatment with drug treatment, since either may increase the risk of hepatic reactions.
• During therapy with this medication, patients should be advised to refrain from other analgesics. Simultaneous use of different NSAIDs in not recommended.
• Gastrointestinal bleeding or ulceration/ perforation can occur at any time during treatment with or without warning symptoms or a previous history of gastrointestinal events. If gastrointestinal bleeding or ulceration occurs, this should be discontinued. medication should be used with caution in patients with gastrointestinal disorders, including history of peptic ulceration, history of gastrointestinal haemorrhage, ulcerative colitis or crohn’s disease.
• In patient with renal or cardiac  impairment, caution is required since the use of Nimesulide-mav result in deterioration of renal function. In the event of deterioration, the treatment should be discontinued.
• Elderly patients are particularly susceptible to the adverse effects of NSAIDs, including gastrointestinal haemorrhage and perforation, impaired renal, cardiac and hepatic function. Therefore, appropriate clinical monitoring is advisable.
• As nimesulide can interfere with platelet function, it should be used with caution in patients with bleeding diathesis. Howerer, it is not a substitute for acetylsalicylic acid for cardiovascular prophylaxis.

Nice Tablets Side Effects

• Blood disorders

Rare: Anemia, Eosinophilia Very Rare: Thrombocytopenia, Pancytopenia, Purpura

• Immune System Disorders

Rare: Hypersensitivity Very Rare: Anaphylaxis

• Metabolism And Nutrition Disorders

Rare: Hyperkalemia

• Psychiatric Disorders

Rare: Anxiety, Nervousness, Nightmare

• Nervous System Disorders

Uncommon: Dizziness Very Rare: Headache, Somnolence, Encephalopathy (Reye’s syndrome)

• Eye Disorders

Rare: Vision Blurred* Very Rare: Visual Disturbance

• Ear And Labyrinth Disorders

Very Rare: Vertigo

• Cardiac disorders

Rare: Tachycardia

• Vascular disorders

Uncommon: Hypertension Rare: Haemorrhage, Blood pressure fluctuation, Hot flushes

• Respiratory Disorders

Uncommon: Dyspnoea Very Rare: Asthma, Bronchospasm

• Gastrointestinal Disorders

Common: Diarrhoea, Nausea, vomiting Uncommon: Constipation, Flatulence, Gastritis, Gastrointestinal bleeding, Duodenal ulcer And perforation, Gastric ulcer and perforation Very Rare: Abdominal pain, Dyspepsia, stomatitis, Melaena

• Hepatobiliary Disorders

Common: Hepatic enzymes  increased Very Rare: Hepatitis, Fulminant hepatitis (including fatal cases) jaundice, cholestasis

• Skin And Subcutaneous Tissue Disorder

Uncommon: Pruritus, Rash, Sweating increased Rare: Erythema, Dermatitis Very Rare: Urticaria, Angioneurotic oedema, face oedema, erythema multiforme, stevens johnson syndrome, toxic epidermal necrolysis

• Renal And urinary Disorders

Renal: Dysuria, Haematuria, Urinary Retention Very Rare: Renal Failure, Oliguria, Interstitial nephritis

• General Disorders

Uncommon: Oedema Rare: Malaise, Asthenia Very Rare: Hypothermia

• Investigations

Common: Hepatic enzymes increased* Frequency based on clinical trials

Drug Interactions Information

Pharmacodynamics Interactions

patients receiving warfarin or similar anticoagulant agent or acetylsalicylic acid have an increased risk of bleeding complications, when treated with nimesulide. Therefore this combination is not recommended and is contraindicated in patients with severe coagulation disorders. If the combination cannot be avoided, anticoagulant activity should be monitored closely.

Pharmacodynamics/Pharmacokinetic interactions with diuretics

Meanwhile, In healthy subjects, nimesulide transiently decreases the effect of furose – mide on sodium excretion and to a lesser extent, on potassium excretion and reduces the diuretic response, Co-administration of this medication and furose – mide results in a decrease (of about 20 %) of the AUC and cumulative excretion of furose – mide, without affecting its renal clearance. The concomitant use of furose – mide and it requires caution in susceptible renal or cardiac patients.

Pharmacokinetic Interactions with other drugs:

• Non-steroidal anti-inflammatory drugs have been reported to reduce the clearance of lithium, resulting in elevated plasma levels and lithium toxicity. If nimesulide are prescribed for a patient receiving lithium therapy, lithium levels should be monitored closely.
• It inhibits CYP2C9, The Plasma concentrations of drugs that are substrates of this enzyme may be increased when nimesulide are used concomitantly.
• Caution is required if Medicine is used less than 24 hours before or after treatment with methotrexate because the serum level of methotrexate might increase and therefore, the toxicity of this drug might increase.
• Due to their effect on renal prostaglandins, prostaglandin synthetase inhibitors like the medicine may increase the nephrotoxicity of cyclosporine.

Use In Special Populations

Nise Tablet In Pregnancy Firstly, The use of nimesulide contraindicated in the third trimester of pregnancy. Like other NSAIDs this medicine not recommended in women attempting to conceive. However, As with other NSAIDs, Known to inhibit prostaglandin synthesis, medicine may cause premature closure of the ductus arteriosus. On the other hand symptoms like pulmonary pulmonary hypertension, oliguria, oligoamines, and increased risk of bleeding, uterine inertia and peripheral oedemic. Furthermore, the  isolated of renal failure in neonates born to women taking nimesulide in late pregnancy. Therefore, the potential risk for humans unknown and prescribing the drug during the first two trimesters of pregnancy also not recommended. Use For Nursing mothers Consequently, Not known whether the medicine is excreted in human milk. Meanwhile, this drug contraindicated during breastfeeding.

Over Dosage Symptoms & Treatment

The symptoms following acute NSAID overdoses usually limited to lethargy, drowsiness, nausea, vomiting and epigastric pain. However, these symptoms generally reversible with supportive care. On the other hand, Gastrointestinal bleeding can also occur. Furthermore, Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. Moreover, Anaphylactic reactions have also reported with therapeutic ingestion of NSAIDs, and may occur following an overdose. Most importantly, the patients should managed by symptomatic and supportive care following an NSAID overdose. However, there are no specific antidotes. NO information  available regarding the removal of nimesulide by hemodialysis. Most importantly, based on its high degree of plasma protein binding (up to 97.5 % ) dialysis unlikely to  useful in overdose. Furthermore, the emesis and /or activated charcoal (60 to 100 g in adults) and/or osmotic cathartic may indicated in patients seen within 4 hours of ingestion with symptoms or following a large overdose. Similarly, the Forced diuresis, alkalization of urine, hemodialysis, or hemoperfusion may not useful due to high protein binding. Renal and hepatic function should monitored.

Storage Instruction Guide

Firstly your must keep these medicines out of the reach of your children. On the other hand, protect the medicine from direct sun light and heat. Most importantly, store it on a cool but dry place and also secure from moisture.

More Medical Information: Himalaya Liv 52 DS Tablets Syrup Uses Dosage Benefits Side Effects Price Details

Nise (Nimesulide) 100 MG Tablets Price Details

• Price In Pakistan: 210 PKR
• Price In India: 195 INR
• Price In USA: 5 USD

 

Disclaimer

All the details of the medicine provided on this website Pharmacy Online Here are only for informational purposes and there is no intent to substitute for professional medical advice, diagnostic, and treatment purposes. Therefore, always get medical advice from any qualified healthcare provider doctor, or pharmacist for any questions about your medical conditions, symptoms, or disorder. So do not disregard the medical advice of your professional healthcare provider or delay it simply because of the information your read here on this website.  Note:– Always Use Any Type Of Medicines Only Under The Supervision Of A Professional Healthcare Provider, Doctor, Or Pharmacist.