Corbis Tablets Bisoprolol 2.5MG, 5MG, 10MG Uses Dosage Side Effects Benefits Formula Ingredients Price

What Is Corbis Bisoprolol Fumarate Tablets And Its Uses Dosage Side Effects?

Corbis Tablets contains a drug named Bisoprolol Fumarate. Bisoprolol Fumarate is cardio selective beta blocking agent. It slows the heart rate and reduces high blood pressure. On the other hand, Bisoprolol Fumarate uses for the treatment of angina (Chest Pain), Hypertension and arrhythmias (irregular heart beats) What Is Bisoprolol Fumarate And What It Used For? Bisoprolol is generally belongs to drug class of beta blockers medications. It mainly used for the treatment of irregular heat beat and any other heart disease. World wide bisoprolol medicines sold under different brand names like Corbis, Concor, and Zebeta. Most importantly, Bisoprolol first found during studies in United States Of America in Year 1976. However, it first approved to use in medicines in USA in year 1986.

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Corbis Bisoprolol Furmarate Tablets Uses & Indication

Corbis Tablets Used For the treatment of:

• Highly Blood pressure (Hypertension)
• Coronary heart disease (Angina Pectoris)
• Stable chronic moderate to severe heart failure

Corbis Bisoprolol Furmarate Tablets Contraindications

Hypersensitivity to Bisoprolol & Hydro – chloro – this -azide Particular caution should be exercised with patients suffering from the following:

• Asthma
• Bronchitis
• Chronic respiratory diseases
• Second and third degree heart block
• Bradycardia less than 50 beats per minute
• Peripheral vascular disease
• Raynaud’s phenomenon.
• Meanwhile, uncontrolled cardiac failure excluding that due to hypertrophic obstructive cardiomyopathy.
• Not to be used during pregnancy or lactation.
• The normal dose should be reduced in elderly patients, or in patients suffering from renal dysfunction.
• Patients with metabolic acidosis and sinus bradycardia.
• Safety and efficacy in children have not established.

Corbis H Tablets Warnings

If Bisorolol is to be withdrawn prior to surgery, at least 48 hours should be allowed to elapse between the last dose and anesthesia. Meanwhile, bisoprolol treatment is to be continued during surgery, are should be taken when using anesthetic agents such as ether, cyclopropane and trichloroethylene. On the other hand,  Vagal dominance, if it occurs, may corrected with atropine (1 – 2 mg i.v.). In the perioperative period it is generally unwise to reduce the dosage to which the patient accustomed. Because there may a danger of aggravation of angina pectoris or of hypertension. On the other hand, A patients normal tachycardia response to hypovolemia or blood loss may obscured during or after surgery. Therefore, particular caution should taken in this regard.

Meanwhile, In patients suffering from ischemic heart disease, treatment should not discontinued abruptly. On the other hand, Caution should be taken in prescribing bisoprolo with Class 1 antidysrhythmic agents such as disopyramide, myocardial depressants, and inhibitors of AV conduction such as calcium antagonists. In addition, Use with caution in combination with verapamil in patients with impaired ventricular function. Most importantly, this combination should not given to patients with conduction abnormalities. Neither drug should be other. It modifies the tachycardia of hypoglycemia. The dosage of bisoprolol should be adjusted in cases of severe renal function impairment.

Corbis Tablets Use In Pregnancy

Administration to pregnant mothers shortly before giving birth or during labour result in the newborn infant being born hypotonic, collapsed or hypoglycemic.

Corbis Tablets Dosage Administration:

Corbis Tablets

Treatment with this product must be started at a low dose and increased gradually. Corbis 2.5 mg should be taken once daily for one week. The dosage can be gradually increased to either 5mg or 10mg upon prescription of the registered medical practitioner only. Corbic 5 mg tablets should taken once a day in the morning. Either on an empty stomach or with breakfast. However, If necessary, the dosage can be increased to 10 mg in the morning. Meanwhile, an increase in the dosage to 20 mg daily may sometimes be necessary. On the other hand, The dose should always selected individually, particularly according to the heart rate and the therapeutic result. It is not necessary to adjust the dose in patient suffering from mild to moderate disturbance of the liver or renal function. Meanwhile, In patients with severe renal impairment (creatinine clearance <20 mL/min) and in patient with severe liver function disturbance, the daily dose of 10mg bisoprolol must not exceeded. In some of these patient, Having the dose may be necessary. However, the normal dose of beta-blockers should be reduced in elderly patients.

Corbis-H Tablets

Bisoprolo Tablets is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg. Meanwhile hHydro – chloro – this -azide effective in doses of 12.5 to 50 mg. In clinical trials of bisoprolo/Hydro – chloro – this -azide combination therapy using bisoprolol doses of 2.5 to 20 mg and Hydro – chloro – this -azide doses of 6.25 to 25 mg, the antihypertensive therapy may  initiated with the lowest dose of Corbis-H, one 2.5/6.25 mg tablet once daily. Subsequent titration (14 day intervals) may carried out with this up to the maximum recommended dose 20 / 12.5 mg (two 10/6.25 mg tablets) once daily, as appropriate.

Uses In Urdu Hindi

Corbis Tablet Side effects

The use of Corbis Tablet may cause some side effects which includes

• Lassitude
• Dizziness
• Mild headache
• Prespiration
• Bradycardia
• Sleep disorders
• Restlessness
• Cold extremities
• Nausea
• Vomiting
• Diarrhoea
• Skin rash
• Constipation
• Hypotension
• Paradoxical hypertension
• Depression
• Mass gain
• Paraesthesia
• Vision disorders
• Blood disorder
• Fluid retention
• Muscle cramps
• Allergic reaction
• Metabolic disturbances
• Alopecia
• Myopathies
• Stomatitis
• Over psychosis has reported with other beta-blockers.
• Exacerbation of peripheral vascular disease
• Development of Raynaud’s phenomenon (due to the unopposed arteriolar alpha-sympathetic Activation)
• Hypoglycemia
• Skeletal muscle weakness
• Gastro-intestinal disturbance may occur during treatment with beta-blockers
• Severe precipitated vascular disease and even peripheral gangrene may precipitated.

Special Precautions

Abrupt discontinuation of therapy may cause exacerbation of angina pectoris in patients suffering from ischemic heart disease. Discontinuation of therapy should gradual, and patients should advised to limits the extent of their physical activity during the period in which the medicine discontinued. Bronchoconstriction may occur in patients suffering from asthma, bronchitis and other chronic pulmonary diseases. Since its  a highly selective B1-adrenoceptor blocking agent, it may used with caution in patients with chronic obstructive airway resistance may occur. This bronchospasm can usually reversed by commonly-used bronchodilators. Congestive cardiac failure and marked bradycardia may occur. On the other hand it may mask the symptoms of hyperthyroidism. It should used with caution in patient with hypoglycemia.

Drug Interactions

Corbic Tablet:

Most importantly, It can be dangerous to administer bisoprolol concomitantly with the following medicines:

• Hypoglycemic agent
• Phenothiazines
• Various antiarrhythmic agents.
• N.B. – Such medicine interaction can have life threatening consequences. It may enhance the effects of hypoglycemic agents in the patients with diabetes mellitus as well as the effects of myocardial depressants such as lignocaine, procainamide and quinidine. The effects may  antagonized by beta-adrenoceptor stimulating dangerously reversed by dangerously enhanced by alpha-adrenoceptor stimulants. On the other hand, the effect may enhanced by adrenergic neuron blocking agents such as guanethidine and reserpine. The anesthetist should  informed of bisoprolol therapy prior to any operation. The half-life of bisoprolol can  slightly shortened by the simultaneous administration of rifampicin. An increase in the dose is generally unnecessary.

Corbic-H Tablets:

When given concurrently the following drug may interact with thiazide diuretics, Alcohol, barbiturates, or narcotics – potentiation of orthostatic hypotension may occur, Antidiabetic drugs (oral agents and insulin) – dosage adjustment of the antidiabetic drug may be required. Other antihypertensive drug – additive effect or potentiation. Cholestyramine and colestipol resins – Absorption of Hydro – chloro – this -azide impaired in the presence of anionic exchange resins. Single doses of cholestyramine and colestipol resins bind the Hydro – chloro – this -azide and reduce its absorption in the gastrointestinal tract by up to 85 percent and 43 percent respectively.

Overdosage Symptoms And Treatment

Corbi Tablet overdosage may produce bradycardia and severe hypotension. Bronchospasm and heart failure may produced in certain individuals. Bradycardia associated with severe hypotension should treated with intravenous atropine (1 – 2 mg). However, If necessary this should followed up by a slow intravenous infusion of 25ug isoprenaline. Meanwhile, Bronchospasm should treated with intravenous aminophylline, and heart failure with digitalis and diuretics.

Storage Instructions

Most importantly, always remember to keep all the keep the tablets out of the reach of the children. On the other hand, store the Corbis tablet at a dry and cool place below 30 C temperature. In addition, also protect it from direct sun light and heat.

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Corbis H Tablets Bisoprolol Fumarate 2.5mg, 5mg, 10mg Price Details

• Price In USA= 2 USD
• Price In India= 155 INR
• Price In Pakistan= 185 PKR

 

Disclaimer

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