Limigzol Tablets Best & Strongest Migraine Medicine Uses & Side Effects
Limigzol Tablets 2.5 MG is a brand name of Zolmitriptan. Zolmitriptan selective serotonin (5-HT), antagonist. It considered the Strongest Migraine Medicine to use in migraine attacks. Furthermore, Used in the treatment of acute migraine attacks but it does not prevent migraine attacks.
What Is Zolmitripton And What It Used For?
Zolmitripton is an oral medication first discovered in year 1990 in USA. It belongs to the drug class as an selective serotonin receptor agonist belongs to 1B and 1D subtypes of medicines. It considered as one of the best triptan medication for the treatment of migraine attacks either with cluster headache or without it. On the other hand, it mainly sold under the brand names of Limigzol, Zomig, in most parts of the world including USA, Europe, India And Pakistan.
Uses In Urdu Hindi
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Strongest Migraine Medicine Composition Formula Ingredients
- Oral Disintegrating Tablets Contains: Zolmitriptan 0.2 MG Tablets
Limigzol Tablets (Zolmitriptan) Uses & Indications
Mostly this medications considered as one of the Strongest Migraine Medicine. And zolmitripton tablets 2.5 mg used for the acute treatment of migraine with or without aura.
Limigzol Tablets (Zolmitriptan) Dosage
The recommended Limigzol (Zolmitriptan) dose orally disintegrating tab to treat a migraine is 2.5 mg .
The medication orally disintegrating cap rapidly dissolve when placed on the tongue and is swallowed with the patient’s saliva. A drink of water not required when taking 2.5 MG orally disintegrating tablet. On the other hand, orally disintegrating tablets can be taken when water is not available thus allowing early administration of treatment for a migraine attack. This formulation may also be beneficial for patients who suffer from nausea and are unable to drink during a migraine attack. Or for patients who do not like swallowing conventional tablets. These Best Medicine For Migraine Tablets orally disintegrating capsule provide significant efficacy within 1 hour of dosing.
If symptoms persist or return within 24 hours, a second dose has been shown to be effective. If a second is required, it should not be taken within 2 hours of the initial dose. Patients do not achieve satisfactory relief with 2. 5 mg doses subsequent attacks can be treated with 5 mg doses of tabs. Similarly, it equally effects whenever the capsule taken during a migraine attack. Although it advisable that these tablets taken as early as possible after the onset of migraine headaches. Meanwhile, In the event of recurrent attacks, it recommended that the total intake of the medication in a 24 hour period should not exceed 10 mg. Furthermore, its not not indicated for prophylaxis of migraine
Use in children
Safety and effects of Limigzol (Zolmitriptan) 2.5 MG in pediatric patients have not established.
Use in the Elderly
The safety and efficacy of these tablets, in individuals aged over 65 years have not systematically evaluated.
Patients with Hepatic Impairment
Although metabolism reduced in patients with mild or moderate hepatic impairment, no dosage adjustment is required. However, for patients with severe hepatic impairment, a maximum dose of 5 mg in 24 hours is recommended.
Patients With Renal Impairment
No dosage adjustment requires.
Contraindications Details
This medicine contraindicated in patients with:
- Known hypersensitivity to any component of the product
Special Warnings And Precautions For Use
It should only be used where a clear diagnosis of migraine has been established. Care should taken to exclude other potentially serious neurological conditions. There are no data on the use of drug in hemiplegic or basilar migraine. Migraineurs may be at risk of certain cerebrovascular events. Cerebral hemorrhage, subarachnoid hemorrhage, stroke, and other cerebrovascular events have been reported in patients treated with 5HT1B/1D agonists.
Limigzol should not give to patients with symptoms Wolff-Parkinson white syndrome or arrhythmias associated with other cardiac accessory conduction pathways. In very rare cases, as with other 5HT 1B/1D agonists, coronary vasospasm, angina pectoris, and myocardial infarction have reported. In patients with risk factors for ischaemic heart disease, cardiovascular evaluation prior to commencement of treatment with this class of compounds, including this medicine recommended. These evaluations, however, may not identify every rare case, serious cardiac events occurred in patients without underlying cardiovascular disease. As with other 5 HT1B/1D agonists, there have rare reports of anaphylaxis anaphylactoid reaction in patients receiving the capsules .
Drug Interactions Information
There is no evidence that concomitant use of migraine prophylactic medication has any effects on the efficacy or unwanted effects of this medication. For example beta-blockers, oral dihydroergotamine and pizotifen. The pharmacokinetics and tolerability of the medication unaffected by acute symptoms treatments such as paracetamol, metoclopramide, and ergotamine. Concomitant administration of other 5HT1B/1 D agonists within 12 hours of the medication treatment should avoided.
Ergot containing drugs have reported causing prolonged vasospastic reactions. Because a theoretical basis that their effects may additive 24 hours should elapse between the use of ergotamine containing. Or ergot type medications like dihydroergotamine or methysergide and zolmitriptan. Conversely, it advised us to wait at least 6 hours following use of tablets before administering ergotamine containing preparation.
Therefore the same dosage reduction recommended with compounds of this type such as fluvoxamine and quinolone antibiotics e.g. ciprofloxacin. Following the administration of rifampicin, no clinically relevant differences in the pharmacokinetics of the medicine or its active metabolite observed.
Limigzol Drug Use In Pregnancy And Lactation
Pregnancy
It should use in pregnancy only if the benefits to the mother justify the potential risk to the fetus. There are no studies in pregnant women, but there is no evidence of teratogenicity in animal studies.
Lactation
Meanwhile, studies have shown that zolmitriptan passes into the milk of lactating animals. No data exist for the passage of it into human breast milk. Therefore, caution should exercised when administering this medication women who are breastfeeding.
Effects On Ability To Drive And Use Machines
There was no significant impairment of the performance of psychomotor tests with doses up 20 mg. Meanwhile, use is unlikely to result in an impairment of the ability of patients to drive or operate machinery. However, it should taken into account that somnolence may occur.
Limigzol 25 MG (Zolmitriptan) Tab Side Effects
However, Limigzol is well tolerated and used as the Best Strongest Medicine For Migraine. While Zolmitriptan Side Effects are typically mild-moderate. transient, not serious, and resolve spontaneously without additional treatment.
Possible Side Effects tend to occur within four hours of dosing and are no more frequent following repeated dosing.
Meanwhile, the following Drug Side Effects have been the most commonly reported:
- Nausea
- Dizziness
- Somnolence
- Warm sensation
- Asthenia
- Dry mouth
There have rare reports of tachycardia and palpitations.
Meanwhile, In very rare cases, as with other 5HT1B/1D agonists, angina pectoris, myocardial infarction have reported. As with other 5HT1B/1D agonists transient increased in systemic blood pressure, very rarely associated with significant clinical events have reported. On the other hand, abnormalities or disturbances of sensation have reported.
- Heaviness
- Tightness
- Pain or pressure may occur in the throat neck
- Limbs and chest
- Myalgia
- Muscle weakness
- Paraesthesia
- Dysaesthesia
As with other 5HT1B/1D agonists, there have been rare reports of hypersensitivity reactions including Anaphylaxis, anaphylactoid reactions, urticaria, and angioedema. As with other acute migraine treatment, including 5HT1B/1D agonists. There have very rare reports of headache, gastrointestinal infarction or necrosis, which may present as bloody diarrhea o abdominal pain have received.
Overdosage Symptoms & Treatment
Volunteers receiving single oral doses of 50 mg commonly experience sedation. Meanwhile, the elimination half-life of zolmitriptan administration is approximately 3 hours. Therefore monitoring of patients after overdose with this should continue for at least 15 hours or while symptoms or signs persist. However, there is no specific antidote to the medication. Meanwhile, In cases of severe intoxication, intensive care procedures recommended. Including establishing and maintaining a patent airway ensuring adequate oxygenation and ventilation and monitoring and support of the cardiovascular system. However, It is unknown what effects hemodialysis or peritoneal dialysis has on the serum concentrations of zolmitriptan.
Full Drug Storage Instructions
Most importantly keep your medications out of the reach of children. On the other hand, store the oral drug in a controlled room temperature between 15 C to 30 C. In addition, also protect the drug from heat and sunlight.
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Limigzol (Zolmitripatn) Tablets 2.5 MG Price Details
- Price In Pakistan: 657 PKR
- Price In India: 595 INR
- Price In USA: 10 USD