What Are Motival Tablets Uses Dosage Side Effects – A Comprehensive Guide

A Brief Guide Of Motival Tablets Uses Side Effects?

Tab Motival Tablets 05 MG and 10 MG are mainly a combination of Fluphenazine and Nortriptyline HCL. Fluphenazine, a potent antipsychotic medication, is formulated by combining two active ingredients. It is commonly used in the treatment of mental illnesses such as schizophrenia and depression disorder. As a neuroleptic medication, fluphenazine exerts its effects by blocking specific neurotransmitters in the brain, making it a powerful tool in managing these conditions.

 

 

Other Important Details About This Product

• Manufacturer/Marketer:

Bristol Mayers Squibb are the main marketer and manufacturer of motibal tab world wide. However the price of the tab is different in different regions of the world.

Nortriptyline HCL, belonging to the dibenzocycloheptene class of drugs, is a tricyclic antidepressant. It is an active metabolite of amitriptyline and is commonly prescribed for depression and chronic neurogenic pain. By elevating specific neurotransmitters in the brain, Nortriptyline HCL alleviates depression and pain.

When combined with Fluphenazine, these medications work synergistically to offer a comprehensive treatment option for individuals suffering from mental illness and chronic pain. However, it is crucial to note that these medications should only be used under the guidance of a qualified healthcare professional, as they may have serious side effects if not used properly.

 

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What Are Motival Tablets Uses & Indications?

Motival tablets are primarily prescribed for short-term treatment of moderate to severe symptoms of mixed anxiety and depression in patients. Additionally, healthcare professionals often prescribe this medication for various sleep disorders. It is vital to note that Motival tablets should only be taken under the supervision of a qualified healthcare professional.

Interestingly, Motival tablets have also been utilized in pigeons for various treatments. However, before administering this medication to animals, its safety and efficacy should be thoroughly evaluated by a veterinarian. In summary, Motival tablets are a versatile medication used for a wide range of conditions, but responsible use in accordance with medical guidance is essential.

Motival Tablet Dosage & Administration

Motival in most cases given orally to all age patients. A minimum of two weeks from the start of motivational treatment may pass before antidepressant effects start to manifest. Meanwhile, increasing the dosage won’t decrease this time frame; instead, it’ll make unpleasant responses more common.

Motival Tables For Adults:

Typically, an adult would take one 0.5/10mg Motival tablet three times a day. The whole daily dosage may also be taken at night. However, an alternate therapy should be taken into consideration if there is no improvement after four weeks.

It is important to highlight that, in order to prevent neurological or cardiovascular consequences, the duration of Motival therapy should not exceed three weeks. which old people are especially prone to. Older people should often get a lower dose than younger adults. Additionally, the reaction should be closely watched to see whether a dose increase is required.

What Are The Tab 5 MG, 10 MG Contraindications?

Most importantly, the medication in the form of capsules, syrup, injection or tab is generally contraindicated in patients with:

• patients with a history of hypersensitivity to Motivate, any of the excipients, any other phenothiazine, or dibenzazepine.
• During the acute recovery period after myocardial infarction.
• Patients with suspected or established subcortical damage.
• In comatose or severely depressed states.
• In confusional states with excitation
• Patients with blood dyscrasias or liver damage.
• The first trimester of pregnancy.
• Patients under 18 years of age

What Are The Motival Tablets Use In Pregnancy and Lactation?

It is important to remember that using this drug during the first trimester of pregnancy is not advised. It should only be given in later phases if it is absolutely required and only under close medical monitoring. Additionally, newborns are exposed to fluphenazine during the third trimester of pregnancy. Whether by traditional or atypical antipsychotics may develop various degrees of extrapyramidal or withdrawal symptoms after delivery.

Agitation, hypertension, hypotension, tremors, somnolence, respiratory discomfort, problems with food intake, and other symptoms may be present. To protect the safety of both the mother and the child in such situations, close supervision and medical assistance are essential.

What Are The Drug Interactions To Use Motival?

When using Motival tablets, caution should be exercised in patients known to be poor CYP2D6 metabolizers. Concurrent administration of amphetaminic or anorectic agents may result in antagonistic pharmacological effects. Similarly, concurrent use of antacids or antidiarrheal agents may produce antagonistic effects, and antacids should be spaced at least 1 hour before or 2-3 hours after the dose.

Nortriptyline’s metabolism may be affected when combined with antiarrhythmics (class), such as quinidine or procainamide, leading to a reduced total body clearance and possibly dose-related additive effects on cardiac conduction. Beta-blockers and fluphenazine hydrochloride plasma levels can rise, requiring a dose decrease for both medications.

Alcohol and other CNS depressants may have an exacerbated effect on the patient when taken with other CNS depressants, alcohol, or analgesics. Narcotic analgesics may produce hypotension as well as CNS or respiratory depression when used together. To ensure the safe and successful administration of Motival tablets in patients taking certain concurrent drugs, careful monitoring and medical assistance are required.

• Fluoxetine:

Meanwhile, a Greater than two-fold increase in previously stable plasma levels of nortriptyline occurred when fluoxetine medicine was administered.

• Methyphendrate:

Concurrent administration of tricyclic antidepressants with methylphenidate may cause paranoia. ideation.

• Adverse Events:

A few adverse that have been reported with tricyclic antidepressants other than nortriptyline are included below because of the pharmacologic similarities among the tricyclic antidepressant drug. Many of the events have been reported with fluphenazine hydrochloride use at higher doses than those in this combination.

• Blood and lymphatic system disorder:

Sublingual adenitis, agranulocytosis, aplastic anemia, leukopeni9a, eosinophilia, purpura, thrombocytopenia, and pancytopenia.

• Immune system disorder:

Some potential adverse reactions associated with the use of Motival tablets include cross-sensitivity reactions with other tricyclic drugs, asthma, and edema (such as laryngeal, facial, or tongue swelling).

Anaphylactic reactions, Nervous system disorders may include headache, confusion, drowsiness, dizziness, lethargy, delirium, numbness, tingling or paresthesia of extremities, incoordination, ataxia, tremors, peripheral neuropathy, seizures, alterations in EEG patterns, alterations in CDF proteins, tinnitus, cerebral edema, extrapyramidal symptoms (such as pseudo parkinsonism, dystonia, dyskinesia, akathisia, oculogyric crisis, opisthodomos, and hyperreflexia; these symptoms are usually reversible.

But in some cases may persist after long-term use); neuroleptic malignant syndrome, suicidal ideation, and suicidal behavior. Renal and urinary disorders may include urinary retention, delayed micturition, polyuria, bladder paralysis, and urine frequency nocturia. During pregnancy, puerperium, perinatal conditions, neonatal withdrawal syndrome, and extrapyramidal symptoms may occur.

Reproductive system and breast disorders may include gynecomastia in males, breast enlargement, galactorrhea in females, testicular swelling, abnormal lactation, menstrual irregularities, false results on pregnancy tests, impotence, and changes in libido. It is important to be aware of these potential adverse reactions and to seek medical guidance if any of these symptoms occur while using Motival tablets.

What Are The Warnings & Precautions For Its Use? 

Before taking Motival tablets, it’s crucial to inform your healthcare provider about your medical history, including any existing health conditions, allergies, or medications you are currently taking. Motival tablets may not be suitable for everyone, and your healthcare provider will determine if it’s safe for you to take this medication. It’s important to exercise caution while taking Motival tablets, especially in the following situations:

• Pregnancy and breastfeeding: Motival tablets should be used with caution during pregnancy and breastfeeding, as they may pose risks to the developing fetus or newborn. It’s essential to discuss the potential risks and benefits with your healthcare provider.
• Use in older age patients: Such patients may be more susceptible to the side effects of Motival tablets, such as drowsiness, dizziness, and falls. Close monitoring and dosage adjustments may be necessary.
• Interactions with other medications: Motival tablets may interact with other medications, including other antidepressants, sedatives, antihistamines, and medications for high blood pressure. It’s important to inform your healthcare provider about all the medications you are taking to avoid potential

Overdose Symptoms & Treatment Guide

In case of an overdose, Motival tablets can cause serious toxicity. The severity of the response to overdose may vary depending on factors such as age, the amount ingested, the amount absorbed, and the time elapsed since ingestion. Regardless of age, an overdose should be considered as serious and potentially fatal, and treated as a medical emergency. The major signs and symptoms of toxic overdose with tricyclic antidepressants are usually an exaggeration of common adverse reactions. Symptoms of overdose may manifest within a few hours of ingestion. Seeking immediate medical attention is crucial in case of a suspected overdose.

• CNS symptoms
• Restlessness
• Drowsiness
• Sedation confusion
• Excitement
• Agitation
• Muscle rigidity
• Ataxia
• Hyperactive reflexes
• Choreographic movement
• Abnormal
• Eye movements.

Treatment:

The drug should be withdrawn and symptoms treated sportively in managing overdose, considering pharmacokinetics. On the other hand, Blood and urine levels of tricyclic antidepressants are normally unreliable predictors of clinical management. As well as outcome and primarily useful for diagnosing overdose. Most importantly, Intensive care procedures are recommended, including establishing and maintaining a patent airway. As well as ensuring adequate oxygenation and ventilation and monitoring and support of the cardiovascular system.

 

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Motival Tablets Syrup Injection Capsules Price

• Price In Pakistan: 499 PKR
• Price In India: 380 INR
• Price In USA: 7 USD

References:-

• https://www.sciencedirect.com/science/article/abs/pii/S0033318272714474
• https://dawaai.pk/medicine/motival-380.html
• https://www.dvago.pk/p/motival-tablets-100s