Nootropil Tablets Injection
Nootropil Tablets Injection contains Piracetam which is an anticonvulsants. Piracetam Uses as an adjunct to other drug in cortical myoclonus (spontaneous jerky movement in epilepsy).
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Nootropil Tablets Injection Indications
Adults
Nootropil Uses for Symptomatic treatment of the psycho organic syndrome whose features improved by treatment are
- Memory loss,
- Attention disorders and lack of drive,
- Treatment of cortical myoclonus, alone or in combination,
- Treatment of vertigo
And associated disorders of balance, with the exception of dizziness of vasomotor or psychic origin. Prophylxis and remission of sickle cell vaso occlusive crises.
Children
Treatment of dyslexia, in combination with appropriate measures such as speech therapy, prophylaxis and remission of sickle cell vaso occlusive crises.
Nootropil (Piracetam) Tablets Dosage And Administration
The Nootropil Medicine used as directed by physician.
Oral Formulation
Piracetam Drug may be taken with or without food. The film coated Nootropil tablets should be dissolved in liquid. It recommended to take the daily dose in two to four sub doses.
Parenteral Formulation
When parenteral administration needed e.g. swallowing difficulties, unconsciousness. Piracetam can administered intravenously at the same recommended daily dose. The Nootropil solution for injection will administered intravenously over several minutes. And Nootropil solution for infusion will administered continuously at the recommended daily dose over a 24 hour period.
Nootropil (Piracetam) Dose For Adults
Symptomatic Treatment Of Psycho Organic Syndromes
The recommended daily Nootropil dosage ranges from 2.4 g to 4.8 g in two or three sub doses.
Treatment Of Myoclonus Of Cortical Origin
The daily Nootropil dosage should begin at 7.2 g increasing by 4.8 g every three or four days up to a maximum of 24 g in two or three divided doses.
Treatment Of Vertigo
The recommended daily Nootropil dosage ranges from 2.4 g to 4.8 g in two or three divided doses.
Prophylaxis And Remission Of Sickle Cell Vasoocclusive Crises
Most importantly, the recommended daily dose for prophylaxis 160 mg/kg orally in four divided doses.
Therefore, the recommended daily dose for remission 300 mg/kg intravenously in four divided doses. Meanwhile, for sickle cell anaemia the prophylactic Nootropil dosage must be permanent. Therefore, the dose lower than 160 mg/kg/day or irregular intake may result in relapse of crises.
Nootropil (Piracetam) Dosage For Children
Dyslexia
Firstly, The recommended dosage for school age children (from 8 years old) and adolescent is 3.2 g per day. That means Nootropil 8 ml of 20% solution twice per day or 2 tablets of 800 mg in the morning and in the evening usually during the whole period of the school year.
Prophylaxis and remission of sickle cell vaso-occlusive crises
Meanwhile, For children from 3 years old onwards the prophylactic dosage 160 mg/kg/day day divided into 4 divided doses. However, In case of remission a dose of 300mg/kg/day administered intravenously divided into 4 divided doses. So, the prophylactic administration in sickle cell anaemiamust be permanent. However, A dose lower than 160mg/kg/day or an irregular intake may cause a relapse of the illness. Furthermore, Piracetam administered to children with sickle cell anaemia indication in recommended daily doses (mg/kg/day).
Consequently, Piracetam has administered only to a limited number of children in the age range of 1 to 3 years.
Nootropil (Piracetam) Dosage For Elderly
Most importantly, the adjustment of the Piracetam dosage is recommended in elderly patients with compromised renal function. On the other hand, for long term treatment in the elderly regular evaluation of the creatinine clearance required to allow dosage adaptation if needed.
Renal Impairment
Firstly, Piracetam contraindicated in severe renal impairment (renal creatinine clearance of less than 20 ml per minute). The daily Nootropil (Piracetam) dose must be individualized according to renal function. Meanwhile, refer to the following table and adjust the nootropil dose as indicated. To use this ml/min needed. The Clcr in ml/min may estimated from serum creatinine (mg/dl) determination using the following formula:
Hepatic Impairment
Meanwhile, No Nootropil Dosage adjustment is needed in patients with solely hepatic impairment. However, In patients with hepatic impairment and renal impairment, Nootropil dosage adjustment is recommended.
Nootropil Tablets (Piracetam) Contraindications
Most importantly, its contraindicated in Hypersensitivity to piracetam, other pyrrolidone derivatives or any of the excipients, end stage renal disease (renal creatinine clearance of less than 20 ml per minute). Cerebral haemmorrhage.
Nootropil Tablets (Piracetam) Warning And Precautions
Effects on platelet aggregation
Firstly, Due to the Piracetam Side Effects on platelet aggregation, caution is recommended in patients with
- Severe haemorrhage,
- At risk of bleeding such as gastrointestinal ulcer
- Patients with underlying disorders of haemostasis
- With a history of haemorrhagic CVA
- Patients undergoing major surgery including dental surgery
- Patients using anticoagulants or platelet antiagregant drugs including low dose of aspirin.
Renal Insufficiency
Meanwhile, Piracetam eliminated via the kidneys and care should thus betaken in cases of renal insufficiency.
Elderly
Consequently, for long term treatment in the elderly, regularly evaluation of the creatinine clearance is required to allow Piracetam dosage adaptation if needed.
Discontinuation
Furthermore, abrupt discontinuation of treatment with Nootropill tablets should avoided as this may induce myoclonic or generalised seizures in some myoclonic patients.
Sickle Cell Vaso-Occlusive Crises
On the other hand, for sickle cell indication a Piracetam dose lower than 160 mg/kg/day or irregular intake may result in relapse of crises.
Huntington’s disease
Meanwhile, when administering high Piracetam Doses to patients with Hunntington’s Disease a slight deterioration of spontaneous movements was observed.
Nootropil (Piracetam) Drug Interactions
Acenocoumarol, antiepileptic drugs and alcohol. The medicine interaction may result in changes of Piracetam pharmacokinetics expected to be low because approximately 90% of the dose of Piracetam Drug is excreted in the urine as unchanged drug. Confusion, irritability and sleep disorder have reported during concomitant treatment with thyroid extract (T3+T4)
Nootropil (Piracetam) Use During Pregnancy And Lactation
However, Use of the drug during pregnancy and lactation Not recommended. But your doctor or pharmacist will decide according to the condition of an individual patient.
Nootropil (Piracetam) Side Effects
Common: Nervousness, Hyperkinesias, Weight increased
Not Known: Haemorrhagic disorder, anaphylactoid reaction, hypersensitivity, agitation, anaxiety, confusion, hallucination, ataxia, balance disorder, epilepsy, headache, insomnia, vertigo, abdominal pain, diarrhoea, nausea, vomiting, angioedema, dermatitis, pruritus, urticaria
Uncommon: Depression, somnolence, asthenia
Rare: Thrombophlebitis (only parenteral formulation, hypotension (only parenteral formulations, pyrexia (only parenteral formulations), pain at the place of injection (only parenteral formulations).
Nootropil (Piracetam) Overdosage
However, No additional adverse side effects specifically related to overdose have been reported with Piracetam Drug. But The maximum reported overdose with nootropil studied oral intake of 75 g. wherein bloody diarrhoea with abdominal pain was most probably related to the extreme high dose of sorbitol contained in the used formulation
Nootropil (Piracetam) Medicine Storage Guide
Most importantly, store the tablets below 30 c temperature and protect from sunlight and heat and moisture. While on the other hand, store syrup store below 30 C temperature, protect from sunlight, freezing and excessive heat. Furthermore, always remember to keep all your medical products syrups tablets etc out of the reach of your small children at home.
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Nootropil (Piracetam) Tablets, Injection, Syrup