Premarin Tablets Cream Ointment Injection Uses Details
Premarin Tablets Creams Injections combination of a useful drug which named Estrogens Conjugated. Estrogens considered very important in the development and maintenance of the female urogenital system and secondary sex characteristics. Meanwhile, Conjugates estrogens is a mixture of estrogens hormones, which obtained exclusively from natural sources, blended to represent the average composition of material derived from pregnant mares urine. On the other hand, the pharmacological effects of conjugated estrogens looks similar to those of endogenous estrogens.
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Premarin Tablets Injection Cream Uses & Indications
- Premarin Tablets, Injection, Cream use for the treatment of moderate to severe vasomotor symptoms due to menopause .
- Treatment of vulvar and atrophy due to menopause. Meanwhile, when prescribing solely for the treatment of symptoms of vulvar and atrophy , topical products should considered .
- Prevention of postmenopausal osteoporosis in women at risk of future fractures.
- Therapy should start as soon as possible after the onset of menopause.
- Treatment of hyposestrogenism due to hypogonadism, castration or primary ovarian failure.
- Treatment of breast cancer androgen-dependent carcinoma of the prostate (for palliation only) .
Premarin Dosage And Method Of Administration
The benefits and risks of estrogen therapy (ET )must always be carefully weighed. Including consideration of the emergence of risks as therapy continues. Meanwhile, Estrogens with or with out progestines should prescribed at the lowest effective doses. And also for the short duration consistent with treatment goals and risk for the individual women .
Tablets should be taken whole, do not divide, chew, or dissolve tablets in mouth.
Treatment of moderate to sever vasomotor symptoms or vulvar and vaginal atrophy associated with menopause.
Meanwhile, If an estrogen prescribed for a postmenopausal women with a uterus the additional of a progestin may be appropriate. However in some cases hysterectomized women with a history of endometriosis may need a progestin. Meanwhile, in week 52 trial using conjugated estrogens cream alone 0.5 mg twice weekly or 0.5 g 3 weeks on and 1 week off. There was no evidence of endometrial hyperplasia or endometrial carcinoma. Consider topical products when treating solely for vulvar and atrophy.
Prevention Of Postmenopausal Osteoporosis
Most importantly, when Prescribing solely for the prevention of postmenopausal osteoporosis. The therapy should only be considered for women at significant risk of osteoporosis and non estrogen medication should carefully considered.
Treatment Of Female Hypogonadism
- Administer cyclically .
Treatment Of Female Castration Or Primary Over Failure.
- Administer cyclically
Treatment Of Breast Cancer
- 10 mg three times daily,for a period of at least three months .
Use In Children
C E tablet’s Safety and effectiveness in pediatric patients have not been established. Meanwhile, Estrogen treatment of prepubertal girls induces premature breast development and cornification and may induce uterine bleeding .
Use In Elderly Patients
There have not been sufficient number of geriatric women involved in clinical studies utilizing it to determine whether those over 65 years of age .
The women Health Initiative Memory Study
In the whims of postmenopausal women 65 to 79 years of age there was increased risk of developing probable in women receiving estrongen alone when compared to placebo. But, it is not known whether this finding applies to younger postmenopausal women.
Premarin Tablets, Injection, Creams Contraindications
- Known or suspected pregnancy
- Undiagnosed abnormal or uterine bleeding .
- Known , suspected estrogen dependent neoplasa.
- Active or history of confirmed arterial thromboembolic disease
- Active or chronic liver dysfunction or disease .
- Known thrombophillic disorders .
- Hypersensitivity to any component of this medication.
- Breast cancer
Premarin Tablets Injection Creams Side Effects
Infections And Infestations
- Uncommon : Vaginitis, including several other candidiasis
Neoplasms Benign, Malignant And Unspecified
- Rare : Breast cancer, ovarian cancer, fibrocystic breast changes, growth potentiation of benign meningioma
- Very Rare : Endometrial cancer, enlargement of hepatic hemanglomas
Immune System Disorders
- Uncommon : Hypersensitivity
- Rare : Urticaria, angioedema, anaphylactic, anaphylactoid reaction
Metabolism And Nutrition Disorders
- Rare : Glucose intolerance
- Very Rare : Exacerbation of prophyria, hypocalcemai
Psychiatric Disorders
- Uncommon : Changes in libido, mood disturbances, depression, dementia 7
- Rare : Irritability
Nervous System Disorders
- Uncommon : Dizziness, headache, migraine, nervousness
- Rare : Cerebrovascular accident, stroke, exacerbation of epilepsy
- Very Rare : Exacerbation of chorea
Eye Disorders
- Uncommon : Intolerance to contact lenses
- Very Rare : Retinal vascular thrombosis
Cardiac Disorders
- Rare : Myocardial infarction
Vascular Disorders
- Uncommon : venous thrombosis, pulmonary embolism
- Rare : Superficial thrombophlebitis
Respiratory, Thoracic And Mediastinal Disorders
- Rare : Exacerbation of asthma
Gastrointestinal Disorders
- Uncommon : Nausea, bloating, abdominal pain
- Rare : Vomiting, pancreatitis, ischemic colitis
Hepatobiliary Disorders
- Uncommon : Gallbladder disease
- Very Rare : Chloestatic jaudice
Skin And Subcutaneous Tissue Disorders
- Common : Alopecia
- Uncommon : Chloasma, melasma, hirsutism, pruritus, rash
- Very Rare : Erythema multiforme, erythema nodosum
Musculoskeletal And Connective Tissue Disorders
- Common : Arthralgia, Leg cramps
Reproductive System And Breast Disorders
- Common : Abdominal uterine bleeding, breast pain, tenderness, enlargement, discharge, leukorrhea 60
- Uncommon: Change in menstrual flow, change in cervical ectropion and secretion
- Rare : Dysmenorrhea, pelvic pain, galactorrhea, increased size of uterine leiomyomata
- Very Rare : Endometrial hyperplasia
- Unknown : Gynecomastia in males
General Disorders And Administration Site Conditions
- Uncommon : Edema
Investigations
- Common : changes in weight (weight increased or decreased) and increased triglycerides 73
- Very Rare : increase in blood pressure
Premarin Cream Tablet Injection Drug Interactions
Date from a drug drug interaction study involving conjugated estrogen and medroxyprogesterone acetate indicate that the pharmacokinetic disposition of both drugs is not altered when the drugs are co administered. However, other clinical drug, drug interaction studies have not conducted with conjugated estrogens.
On the other hand, in vitro and in vivo studies shown that estrogens are metabolized partially by cytochrome P450 3A4. Therefore, induces or inhibitors of CYP3A4 may affect estrogen drug metabolism.
Interference with Laboratory And Other Diagnostic Tests
Laboratoy test interactions
Firstly, Increased platelet count decreased levels of antithrombin III. And increased plasminogen antigen and activity.
Consequently, Estrogens increase thyroid binding globulin leading to increased circulating total thyroid hormone as measured by protein bound iodine. Furthermore, Estrogens increased thyroid binding globluin leading to increased circulating total thyroid as measured by protein bound iodine. Meanwhile, other proteins may elevated in serum like. corticosteroid binding gloublin, sex hormone binding globulin leading to increased circulating corticosteroid and sex steroids, respectively. Moreover, free or biologically active hormone concentrations may decreased. On the other hand, increased plasma HDL and HDL2 cholesterol subfraction concentrations, reduced LDL cholesterol concentration, increased triglyceride levels, or impaired glucose tolerance. Furthermore, the response to metyrapone may be reduced.
Use In Pregnancy, Fertility and Laction
Premarin Vaginal Cream, tablets, injections should not use during pregnancy. Meanwhile if pregnancy occurs during medication with this ointment treatment should withdraw immediately.
On the other hand, it must not use during the lactation period. But, Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of breast milk . Furthermore, Detectable amounts of estrogens have identified in the milk of mother receiving the drug. Most importantly, caution should exercised when estrogens administered to a nursing woman.
Effects On Ability To Drive And Use Machines
Meanwhile, No studies on the effect of ability to drive or use machine have performed yet.
Overdosage Symptoms & Treatment Guide
Furthermore, the symptoms of over dosage of estrogen containing in adults and children may include nausea, vomiting, breast tenderness, dizziness, abdominal pain, drowsiness and fatigue. On the other hand, in some cases withdrawal bleeding may occur in females. Meanwhile, there is no specific antidote and further treatment. But if necessary should be symptomatic.
Medicine Storage Instructions
Firstly, always keep your medicines out of the reach of your children because it may become a threat to their lives. On the other hand, keep the medicine below 30 C temperature and store it on a cool but dry place. Furthermore, protect it from direct sun light and heat.
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Premarin Tablets Cream Ointment Injections Price (Rs. 2500 PKR )