What Is Vagibact Cream (Clindamycin Phosphate Ointment USP)?
Vagibact Cream contains the drug named Clindamycin which is a very effective antibiotic. Meanwhile, chemically clindamycin is identified as 7-deoxy, 7-chloro derivative of lincomycin, and antobiotic that elaborate by Streptomyces lincolnesis. It is effective much effective against gram positive organism and anaerobic bacteria.
What Is Clindamycin And What It Used For?
Firstly, i want to tell you that it is a antibiotic medication widely used all around the world for the treatment of several type of bacterial infections. It generally sold under the brand names of Vagibact, Clinacin, Dalacin and Cleocin in United States Of America, UK and most parts of the world. Mainly it used for the treatment of the symptoms of bone and joint infections, plevic inflammation, strep throat infections, otitis media, and pneumonia. Most importantly, it found way back in early 19s but first start using in medicines in USA in year 1966 with lincomycin medicine.
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Formula Ingredients & Composition
Each gram contains
- Clindamycin (as Phosphate UPS) 20 mg
Vagibact Cream Dosage And Method Of Administration
Clindamycin inhibits bacterial protein systhesis at the level of the bacterial ribosome. Meanwhile, the antibiotic binds preferentially to 50s ribosomal sub unit and affects the process of peptide chain initiation. Although it is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterial active Clindamycin. In addition, it has been shown to be active in vitro against the following organisms which have been associated with
- Bacterial vaginosis
- Gardnerella
- Mobilunous spp
- Bacteroides spp
- Mycoplasma Hominis
- Peptostreptococcus spp
Approximately 4% (range 0.8-8%) of the administered dose of Clindamycin (100 mg in 5g of cream) absorbed after vaginal administration.
Vagibact Cream Use In Pregnancy In Urdu Hindi
Pharmacokinetic Properties
Following a once a day intravaginal dose of 100 mg of the vaginal cream 2%, administered for 7 consecutive days to 5 woman with bacterial vaginoses, absorption was slower and less variable than that observed in healthy females. Approximately 4% (range 2% to 8%) of the dose absorbed systemically. These peak concentration attained approximately 14 hours post-dosing (range 4-24 hours). There noticed a little or no systemic accumulation of Clindamycin after repeated (7 day) vaginal dosing of this vaginal gel 2 %. The systemic half-life was 1.5 to 2.6 hours.
Vagibact Cream Gel Uses & Indications
Vagibact Cream (Clindamycin Phosphate Vaginal gel) used for Antibiotic for the treatment of bacterial vaginosis. It can be used in several other conditions as doctors and pharmacist may know better according to the patients conditions.
Vagibact Dosage Administration
- One patient should use Vagibact ointment (Clindamycin Phosphate Vaginal Gel) Dose of Approximately 5g of gel intravaginally at bedtime for 7 consecutive nights or as directed by the doctor or the pharmacist.
Its Overdosage Symptoms & Treatment Guide
Vaginally applied this product can be absorbed in sufficient amounts to produce systemic effects. Meanwhile, In the situation of overdosage, general symptomatic and supportive measures are indicated as required. On the other hand, you must contact your doctor or pharmacist immediately.
All Contraindications Details
Generally it is contra-indicated in patient previously found to be hypersensitive to preparation containing this medicine or any of the components of the ointment base. Therefore, It should not used in patients having Lincomycin sensitivity, inflamatory bowel disease, or antibiotic associated colitis.
Precautions & Warnings For Its Use
As there are no data available on the use of VAGIBACT Cream in patients younger than 12 years of age. So, It should not used in this population.
Vagibact Cream Uses In Pregnancy And Lactation
Reproduction studies have been performed in rats and mice using subcutaneous and oral doses of Clindamycin ranging from 20 to 600 mg/kg/day. And it have revealed no evidence of impaired fertility or harm to the fetus due to this medication. On the other hand, there no adequate and well controlled studies in pregnant woman during their first trimester. However because animal reproduction studies not always predictive of human in pregnant woman during second trimester. Meanwhile, it was effective in treating bacterial vaginosis, and no drug related medical events reported in the neonates. However as with any drug used during pregnancy, a careful risk benefit assessment should considered before using it. Meanwhile, It not known that it excreted in breast milk following the use of vaginally administered this medication
Vagibact Cream Side Effects
Like all the other medical products this Ointment gel (Clindamycin Vaginal ointment) also shown some side effects. Meanwhile, the following treatment-related adverse events reported:
- Cervivitis/vaginitis
- Vulvo-vaginal irritation
- Dizziness
- Headache
- Vertigo
- Heartburn
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Abdominal pain
- Rash
- Exanthema
- Urticaria
How To Use and Application of Vagibact Cream
Plastic applicator provided in pack designed to allow proper vaginal administration of the ointment. Firstly, Remove cap from cream tube. Secondly, pierce the seal of the tube by means of the pin on the top of the cap. On the other hand, Screw a plastic applicator on the threaded end of the tube. In addition, Rolling from the bottom, squeeze gently and force the medication into the applicator. At last, The applicator filled when the plunger reaches its predetermined stopping point.
Its Storage Instructions
Most importantly, Store the cream within 30 C temperature and also avoid to freeze the medicine. On the other hand, avoid to expose the medicine to direct sun light and protect from heat. In conclusion, and the most important thing to say that always keep your medicines out of the reach of your small children because that may be risking their life.
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Vagibact (Clindamycin Vaginal Cream) Price Details
- Price In Pakistan: 650 PKR
Price In India: 560 INR - Price In USA: 5 USD