Clexane Injections Dosage, Administration, Uses, Side Effects Price Details

What Is Clexane Injections And What Are Its Uses Dosage Side Effects Price Details?

Clexane Injections: contains Enoxaparin Sodium. Enoxaparin Sodium is an anticoagulant agent which has antithirombotic properties. Enoxaparin Sodium Injection a low molecular weight heparin fraction. It prepared commercially from bovine lung and porcine intestinal mucosa. The generic name is enoxaparin sodium available in different packings. It belongs to the drug class of anticoagulants with low molecular weight heparins. It first found during studies in United States Of America in 1981 and first approved to used in medication in year 1991.
Clexane Injections 40mg 60mg 80mg inj uses dosage side effects price
Enoxaparin Sodium Clexane Injections (2000, 4000, 6000, 8000)

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Formula Ingredients & Composition

  • Injections 20mg-2000/0.2 ml: <————-> Each 0.2 ml contains enoxaparin sodium 20 mg
  • Inj 40 mg-4000/0.4 ml <———————> Each 0.4 ml contains enoxaparin sodium 40 mg
  •  Inj 60mg-6000/0.6 ml <———————> Each 0.6 ml contains enoxaparin sodium 60 mg
  • Injection 80mg-8000/0.8 ml <—————> Each 0.8 ml contains enoxaparin sodium 80 mg

Clexane (Enoxaparin) Injections Uses & Indications

  • Enoxaparin Sodium prophylaxis of venous thromboembolic disease. Meanwhile, In particular those may be associated with orthopedic or general surgery.
  • Injection Enoxaparin Clexane prophylaxis of venous thromboembolism in medical patients bedridden due to acute illness. Including cardiac insufficiency, respiratory failure, severe infections, rheumatic diseases.
  • For the treatment of deep vein thrombosis with or without pulmonary embolism.
  • Used in prevention of thrombus formation in extracorporeal circulation during hemodialysis.
  • Treatment of unstable angina and non-Q-wave myocardial infarction, administered concurrently with aspirin.
  • Treatment of acute ST-segment Elevation Myocardial Infarction (STEMI) including patients to managed medically or with subsequent Percutaneous Coronary Intervention (PCI).

Clexane (Enoxaparin) Injections Dosage And Rout Of Administration

Clexane (Enoxaparin Sodium) Medications injection dosage and route of administration for dvt prophylaxis flying and other symptoms details are as under.
General:
  • Prophylaxis of Venous Thrombosis In Surgical Patients:

However, In patients with a moderate risk of thromboembolism. e.g abdominal surgery. So, The recommended dose is 20mg/0.2 ml. Or 40mg/0.4 ml once daily by subcutaneous inj. Consequently, In general surgery the first dose should given 2 hours before the surgical procedure. On the other hand, In patients with a high risk of thromboembolism e.g. orthopedic surgery. Firstly, The recommended given subcutaneous inj 40mg/0.4 ml dose once daily. Meanwhile, it’s only initiated 12 hours prior to surgery. Or 30 mg dose twice daily initiated 12 to 24 hours after surgery. The treatment is usually prescribed for an average period of 7 to 10 days. Longer treatment duration may be appropriate in some patients. And it should be continued for as long as there is a risk of venous thrombi embolism. And until the patient is ambulatory. Continued therapy with Clexane 40mg/0.4 ml medication once daily for 3 weeks following the initial therapy has proven to be beneficial in orthopedic surgery. For special recommendations concerning dosing intervals for spinal/epidural anesthesia and coronary revascularization procedures.
  • Prophylaxis of Venous Thrombo Embolism in Medical Patients

Enoxaparin Sodium recommended dose is  40mg/0.4 ml once daily by subcutaneous of this product. Treatment with enoxaparin sodium is prescribed for a minimum of 6 days. And continued until the return to full ambulation, for a maximum of 14 days.
  • Treatment of Deep Vein Thrombosis With Or Without Pulmonary Embolism
Enoxaparin Sodium Injection Dose administered subcutaneously either as a single inj of 1.5mg/kg. Or as twice daily injections of 1mg/kg. In patients with complicated thromboembolic disorders a dose of 1mg/kg administered twice daily recommended. The Dose treatment usually prescribed for an average period of 10 days. Oral anticoagulant therapy should initiated when appropriate. And Enoxaparin Sodium Inj Dose treatment should continued until a therapeutic anticoagulant effect has achieved. (International Normalization Ratio 2 to 3)
  • Prevention Of Extra Corporeal Thrombus During Hemodialysis

Recommended Clexane Dose is 1mg/kg for patients with a high risk of hemorrhage. The dose should be reduced to 0.5mg/kg for double vascular access or 0.75ml/kg for single vascular access. During hemodialysis, the dose should introduce into the arterial line of the circuit at the beginning of the dialysis session. The effect of this dose is usually sufficient for a 4 hour session. However, if fibrin rings found for example after a longer than normal session a further dose of 0.5 to 1mg/kg may given.
  • Treatment Of Unstable Angina And Non-Q-Wave Myocardial Infarction:
Its recommended dose is 1mg/kg every 12 hours by subcutaneous injection, administered concurrently with oral aspirin. Treatment with enoxaparin sodium in these patients should prescribed for a minimum of 2 days and continued until clinical stabilization. The usual duration of treatment 2 to 8 days.
  • Treatment Of Accute ST-Segment Elevation Myocardial Infarction:
The recommended dosage for such patients is a single IV bolus of 30 mg plus a 1 mg/kg SC dose followed by 1mg/kg administered SC every 12 hours. When administered in conjunction with a thrombolytic, it should given between 15 minutes before and 30 minutes after the start of fibrinolytic therapy. All patients should receive acetylsalicylic acid as soon as they are identified as having STEMI. And maintained under 75 to 325 mg once daily. Unless contraindicated. The recommended duration of its treatment is 8 days. Or until hospital discharge whichever comes first. For patients managed with percutaneous coronary intervention. If the last product SC administration given less than 8 hours before balloon inflation. No additional dosing need if the last SC administration given more than 8 hours. Before balloon inflation an IV bolus of 0.3mg/kg of medication should administered.
Inj Contradictions Details
Its contraindicated in patients with Hypersensitivity to this medicine heparin or its derivatives including other low molecular weight heparins. History of immune mediated heparin induced thrombocytopenia within the past 100 days or in the presence of circulating antibodies. Active major bleeding and conditions with a high risk of uncontrolled hemorrhage, including recent hemorrhagic stroke.
Precautions & Warnings
General:
Low molecular weight heparins should not used interchangeably since they differ in their manufacturing process. Molecular weights, specific anti-Xa activities, units and dosage. This results in difference in pharmacokinetics and associated biological activities. And platelet specific to each proprietary medicinal product there required. There are some other conditions listed below.
  • Spinal/ Epidural Anesthesia
  • Heparin Induced Thrombocytopenia
  • Percutaneous Coronary Revascularization Procedures

Pregnant Women With Medical Prosthetic Heart Valves

The Clexane Use in Pregnancy for thromboprophylaxis in pregnant women with mechanical prosthetic heart valves has not adequately studied. Meanwhile, In a clinical study of pregnant women  with mechanical prosthetic heart valves given Enoxaparin In Pregnancy (1 mg/kg bid) to reduce the risk of thromboembolism. Therefore, 2 of 8 women developed clots resulting in blockage of the valve and leading to maternal and fetal death. There have been isolated post marketing reports of valve thrombosis in pregnant women with mechanical prosthetic heart valves while receiving the medication for thromboprophylaxis. Pregnant women with mechanical prosthetic heart valves may at higher risk for thrombo embolism.
All About Precautions For Its Use
Most importantly, Do not administer by the intramuscular route.
  • Hemorrhage
  • As with any other anticoagulant therapy. Therefore, it should be used with caution in conditions with increased potential for bleeding.
  • Mechanical Prosthetic Heart Valves
  • Hemorrhage in the Elderly
  • Renal Impairment.
  • Low Weight
  • Obese Patients
  • Monitoring of Platelet Counts.

Enoxaparin Drug Interactions Guide

Most importantly, it recommended that agents which affect hemostasis should discontinued prior to enoxaparin sodium therapy unless strictly indicated. These agents include medications such as:
  • Systemic salicylates, acetylsalicylic acid and NSAIDs including ketorolac.
  • Dextran 40 ticlopidine and clopidogrel
  • Systemic glucocorticoids
  • Thrombolytics and anticoagulants
  • Other anti platelet agents including glycoprotein.
There, If the combination indicated enoxaparin sodium should used with careful clinical and laboratory monitoring when appropriate.

Clexane (Enoxaparin) Use In Pregnancy

Most importantly, this product use in Pregnancy with animal studies not shown any evidence of fetotoxicity or teratogenicity. However, The pregnant rat the transfer of S-Enoxaparin Sodium in pregnancy across the maternal placenta to the fetus is minimal. Meanwhile, In humans no evidence that it crosses the placental barrier during the second trimester of pregnancy. So, No information available concerning the first and the third trimesters. Consequently, No adequate and well-controlled studies in pregnant women and because animal studies not always predictive of human response. Most importantly, This drug should used during pregnancy only if the physician established a clear need.

Use In Lactation

Similarly, in lactating rats the concentration of S-Enoxaparin Sodium or its labelled metabolites in milk very low. However, It is not known whether unchanged it excreted in human breast milk. Consequently, The oral absorption of the product unlikely. However, as a precaution, lactating mothers receiving this medication should advised to avoid breastfeeding.  

Clexane (Enoxaparin) Inj Side Effects

Haemorrhages:

However, in clinical studies of Enoxaparin Side Effects, Hemorrhages are the most common Clexane Side Effects. Meanwhile, It included major hemorrhages, reported at most in 4.2% of the patients. On the other hand, some the cases have fatal. Similarly, as with other anticoagulants, hemorrhage may occur in the presence of associated risk factors such as. Organic lesions liable to bleed, invasive procedures or the concomitant use of medications affecting hemostasis.

Vascular Disorders:

  • Prophylaxis In Surgical Patients:
Very Common<———————> Hemorrhage Rare <——————————–> Retroperitoneal Hemorrhage
  • Prophylaxis in Medical Patients:
Common < ————————–> Hemorrhage
  • Treatment In Patients With DVT With Or Without PE:
Very Common <——————-> Hemorrhage Uncommon <———————-> Intracranial Hemorrhage, Retroperitoneal Haemorrhage
  • Treatment In Patients With Unstable Angina And Non-Q-Wave MI:
Common <————————> Haemorrhage Rare <——————————> Retroperitoneal Hemorrhage
  • Treatment In Patients With Acute STEMI:
Common <————————> Hemorrhage Uncommon <———————> Intracranial hemorrhage, retroperitoneal hemorrhage

Blood And Lymphatic System Disorders:

  • Prophylaxis In Surgical Patients
Very Common <———————–> Thrombocytosis Common <——————————> Thrombocytopenia
  • Prophylaxis In Medical Patients
Uncommon <————————–> Thrombocytopenia
  • Treatment In Patients With DVT With Or Without PE
Very Common <———————–> Thrombocytosis Common <——————————> Thrombocytopenia
  • Treatment In Patients With Unstable Angina And Non-Q-Wave MI
Uncommon <—————————> Thrombocytopenia
  • Treatment In Patients With Acute STEMI
Common <——————————> Thrombocytosis Thrombocytopenia Very Rare<—————————–> Immuno-allergic Thrombocytopenia *platelet increased . 400G/L

Other Clinically Relevant Side Effects:

  • Immune System Disorders:
Common <—————————-> Allergic Reaction Rare <———————————> Anaphylactic / anaphylactoid reaction
  • Hepatobilary Disorders:
Very Common <———————> Hepatic enzymes increase
  • Skin And Subcutaneous Tissue Disorders
Common <—————————-> Urticaria, Pruritus, erythema Uncommon <————————-> Bullous Dermatitis
  • General Disorders And Administration Site Conditions
Common <—————————> Injection Site haematoma, injection site pain and other reactions Uncommon <————————> Local irritation, skin necrosis at injection site

Its Over Dose Symptoms & Treatment Guide

Signs, Symptoms And Severity: Firstly, the accidental Over Dose after intravenous, extracorporeal or subcutaneous administration may lead to hemorrhagic complications. Meanwhile, following oral administration of even large dose. So, It unlikely that enoxaparin sodium will absorbed.
What Are The Inj Product Storage Instructions After Used
Most importantly, the storage temperature must not exceed over 30 C. Do not freeze pre filled syringes. Always aware that keep all the medical products out of the reach of you kids present at home because it may harm there life. On the other hand also protect the injections from direct sunlight and heat.

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Clexane Injections (Enoxaparin) Price In Pakistan (Rs. 500 PKR) In India ( 401 INR) In USA $ 14 USD

 

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Disclaimer

All the information about product uses, dosage side effects, formula, ingredients, indications, contraindications, drug interactions, warnings & precautions as well as it’s safe to use during pregnancy and lactation is purely based on the information available on the internet. And it is only provided here for general education and information purposes only. So do not take action about any of the information you found here because we do not guarantee the authenticity of each and every piece of information available on this website. All the information we produced is purely based on FDA-approved literature and does not substitute professional medical advice. This information is not intended to substitute medical advice, diagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical condition.

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