What Is Clexane Injections And What Are Its Uses Dosage Side Effects Price Details?
Clexane Injections: contains Enoxaparin Sodium. Enoxaparin Sodium is an anticoagulant agent which has antithirombotic properties. Enoxaparin Sodium Injection a low molecular weight heparin fraction. It prepared commercially from bovine lung and porcine intestinal mucosa. The generic name is enoxaparin sodium available in different packings. It belongs to the drug class of anticoagulants with low molecular weight heparins. It first found during studies in United States Of America in 1981 and first approved to used in medication in year 1991.More Useful Links: Amoxil Capsules Syrup Uses, Dosage, Side Effects Benefits Formula Price In Pakistan
Formula Ingredients & Composition
- Injections 20mg-2000/0.2 ml: <————-> Each 0.2 ml contains enoxaparin sodium 20 mg
- Inj 40 mg-4000/0.4 ml <———————> Each 0.4 ml contains enoxaparin sodium 40 mg
- Inj 60mg-6000/0.6 ml <———————> Each 0.6 ml contains enoxaparin sodium 60 mg
- Injection 80mg-8000/0.8 ml <—————> Each 0.8 ml contains enoxaparin sodium 80 mg
Clexane (Enoxaparin) Injections Uses & Indications
- Enoxaparin Sodium prophylaxis of venous thromboembolic disease. Meanwhile, In particular those may be associated with orthopedic or general surgery.
- Injection Enoxaparin Clexane prophylaxis of venous thromboembolism in medical patients bedridden due to acute illness. Including cardiac insufficiency, respiratory failure, severe infections, rheumatic diseases.
- For the treatment of deep vein thrombosis with or without pulmonary embolism.
- Used in prevention of thrombus formation in extracorporeal circulation during hemodialysis.
- Treatment of unstable angina and non-Q-wave myocardial infarction, administered concurrently with aspirin.
- Treatment of acute ST-segment Elevation Myocardial Infarction (STEMI) including patients to managed medically or with subsequent Percutaneous Coronary Intervention (PCI).
Clexane (Enoxaparin) Injections Dosage And Rout Of Administration
Clexane (Enoxaparin Sodium) Medications injection dosage and route of administration for dvt prophylaxis flying and other symptoms details are as under.General:
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Prophylaxis of Venous Thrombosis In Surgical Patients:
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Prophylaxis of Venous Thrombo Embolism in Medical Patients
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Treatment of Deep Vein Thrombosis With Or Without Pulmonary Embolism
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Prevention Of Extra Corporeal Thrombus During Hemodialysis
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Treatment Of Unstable Angina And Non-Q-Wave Myocardial Infarction:
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Treatment Of Accute ST-Segment Elevation Myocardial Infarction:
Inj Contradictions Details
Its contraindicated in patients with Hypersensitivity to this medicine heparin or its derivatives including other low molecular weight heparins. History of immune mediated heparin induced thrombocytopenia within the past 100 days or in the presence of circulating antibodies. Active major bleeding and conditions with a high risk of uncontrolled hemorrhage, including recent hemorrhagic stroke.Precautions & Warnings
General:
Low molecular weight heparins should not used interchangeably since they differ in their manufacturing process. Molecular weights, specific anti-Xa activities, units and dosage. This results in difference in pharmacokinetics and associated biological activities. And platelet specific to each proprietary medicinal product there required. There are some other conditions listed below.- Spinal/ Epidural Anesthesia
- Heparin Induced Thrombocytopenia
- Percutaneous Coronary Revascularization Procedures
Pregnant Women With Medical Prosthetic Heart Valves
The Clexane Use in Pregnancy for thromboprophylaxis in pregnant women with mechanical prosthetic heart valves has not adequately studied. Meanwhile, In a clinical study of pregnant women with mechanical prosthetic heart valves given Enoxaparin In Pregnancy (1 mg/kg bid) to reduce the risk of thromboembolism. Therefore, 2 of 8 women developed clots resulting in blockage of the valve and leading to maternal and fetal death. There have been isolated post marketing reports of valve thrombosis in pregnant women with mechanical prosthetic heart valves while receiving the medication for thromboprophylaxis. Pregnant women with mechanical prosthetic heart valves may at higher risk for thrombo embolism.All About Precautions For Its Use
Most importantly, Do not administer by the intramuscular route.- Hemorrhage
- As with any other anticoagulant therapy. Therefore, it should be used with caution in conditions with increased potential for bleeding.
- Mechanical Prosthetic Heart Valves
- Hemorrhage in the Elderly
- Renal Impairment.
- Low Weight
- Obese Patients
- Monitoring of Platelet Counts.
Enoxaparin Drug Interactions Guide
Most importantly, it recommended that agents which affect hemostasis should discontinued prior to enoxaparin sodium therapy unless strictly indicated. These agents include medications such as:- Systemic salicylates, acetylsalicylic acid and NSAIDs including ketorolac.
- Dextran 40 ticlopidine and clopidogrel
- Systemic glucocorticoids
- Thrombolytics and anticoagulants
- Other anti platelet agents including glycoprotein.
Clexane (Enoxaparin) Use In Pregnancy
Most importantly, this product use in Pregnancy with animal studies not shown any evidence of fetotoxicity or teratogenicity. However, The pregnant rat the transfer of S-Enoxaparin Sodium in pregnancy across the maternal placenta to the fetus is minimal. Meanwhile, In humans no evidence that it crosses the placental barrier during the second trimester of pregnancy. So, No information available concerning the first and the third trimesters. Consequently, No adequate and well-controlled studies in pregnant women and because animal studies not always predictive of human response. Most importantly, This drug should used during pregnancy only if the physician established a clear need.Use In Lactation
Similarly, in lactating rats the concentration of S-Enoxaparin Sodium or its labelled metabolites in milk very low. However, It is not known whether unchanged it excreted in human breast milk. Consequently, The oral absorption of the product unlikely. However, as a precaution, lactating mothers receiving this medication should advised to avoid breastfeeding.Clexane (Enoxaparin) Inj Side Effects
Haemorrhages:
However, in clinical studies of Enoxaparin Side Effects, Hemorrhages are the most common Clexane Side Effects. Meanwhile, It included major hemorrhages, reported at most in 4.2% of the patients. On the other hand, some the cases have fatal. Similarly, as with other anticoagulants, hemorrhage may occur in the presence of associated risk factors such as. Organic lesions liable to bleed, invasive procedures or the concomitant use of medications affecting hemostasis.Vascular Disorders:
- Prophylaxis In Surgical Patients:
- Prophylaxis in Medical Patients:
- Treatment In Patients With DVT With Or Without PE:
- Treatment In Patients With Unstable Angina And Non-Q-Wave MI:
- Treatment In Patients With Acute STEMI:
Blood And Lymphatic System Disorders:
- Prophylaxis In Surgical Patients
- Prophylaxis In Medical Patients
- Treatment In Patients With DVT With Or Without PE
- Treatment In Patients With Unstable Angina And Non-Q-Wave MI
- Treatment In Patients With Acute STEMI
Other Clinically Relevant Side Effects:
- Immune System Disorders:
- Hepatobilary Disorders:
- Skin And Subcutaneous Tissue Disorders
- General Disorders And Administration Site Conditions
Its Over Dose Symptoms & Treatment Guide
Signs, Symptoms And Severity: Firstly, the accidental Over Dose after intravenous, extracorporeal or subcutaneous administration may lead to hemorrhagic complications. Meanwhile, following oral administration of even large dose. So, It unlikely that enoxaparin sodium will absorbed.What Are The Inj Product Storage Instructions After Used
Most importantly, the storage temperature must not exceed over 30 C. Do not freeze pre filled syringes. Always aware that keep all the medical products out of the reach of you kids present at home because it may harm there life. On the other hand also protect the injections from direct sunlight and heat.More Medications: Vastarel MR 35 MG Tablets Uses, Dosage, Side Effects Benefits Formula Ingredients Price Details
Clexane Injections (Enoxaparin) Price In Pakistan (Rs. 500 PKR) In India ( 401 INR) In USA $ 14 USD
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