Tab Motival Tablets Uses Dosage Side Effects For Anxiety & Sleep Details
Tab Motival Tablets 05 MG and 10 MG are basically the combinations and the formulation of Fluphenazine and Nortriptyline HCL. So, as you know Fluphenazine is an antipsychotic useful medicine which also known as neuroleptic medicine. And on the other hand, Nortriptyline HCL is a tricyclic anti-depressant of the dibenzo cycloheptene type which is an active metabolite of amitriptyline. It used to treat depression and for the management of chronic neurogenic pains.
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Motival Tablets Uses & Indications
Most importantly, the main question is what motival tablets used for? So the answer is that product usually used for the short-term treatment of patients suffering from moderate to symptoms of mixed anxiety and depression. On the other hand, doctors also use this medicine to treat several sleep disorders in different patients. On the other hand some times it also used in pigeons for several treatments.
Motival Tablet Dosage & Administration
Motival is generally administered in all the patients orally. Therefore, Antidepressant effects may not occur for 2 or more weeks after the initiation of motivating therapy. Meanwhile, Increasing the dose will not shorten this period but rather increase the incidence of adverse reactions.
Motival Tables For Adults:
The usual adult dose of motive is one .05/10-mg tablet three times daily; as an alternative regimen, the total daily dose may be given once a day, usually at bedtime. However, if the patients does not respond after four weeks an alternative treatment should be given. Meanwhile, a course of treatment with it should be limited to three neurological. Or cardiovascular complications, to which the elderly are especially vulnerable. In general, the lover does should be given to elderly patients than to younger adults. Consequently, the response should be monitored If the dosage should be gradually increased.
Tab 5 MG, 10 MG Contraindications
Most importantly, the medication is generally contraindicated in patients with:
- patients with a history of hypersensitivity to Motivate, any of the excipients, any other phenothiazine, or dibenzazepine.
- During the acute recovery period after myocardial infarction.
- Patients with suspected or established subcortical damage.
- In comatose or severely depressed states.
- In confusional states with excitation
- Patients with blood dyscrasias or liver damage.
- The first trimester of pregnancy.
- Patients under 18 years of age
Motival Tablets Use In Pregnancy and Lactation
Most importantly, this medicine contraindicated in the first trimester of pregnancy. In the later period, the product should administered only if clearly needed and under direct medical supervision. On the other hand, Neonates exposed to conventional or atypical antipsychotics, including fluphenazine during the third trimester of pregnancy are at risk of side effects including extrapyramidal or withdrawal symptoms that may ver in severity and education following the birth. They have been reports of agitation, hypertension, hypotension, tremor, somnolence, respiratory, distress, food intake, disorders.
Tab Drug Interactions Details
Most importantly, use motival tablets with caution in patients known to be poor CYP2D6 metabolizers.
Amphetaminic, anorectic agents: Concurrent administration may produce antagonistic pharmacological effects.
Antacids, antidiarrheal agents: Concurrent administration may produce antagonistic pharmacological effects. of antacids should spaced at least 1 hours before or 2-3 hours after the dose.
Antiarrhythmics (class) Concurrent administration of the product with quinidine, procainamide or similar agents may after the metabolism of nortriptyline, resulting in decreased total body clearance of this drug, and may cause dose-related additive effects on cardiac conduction.
Beta-Blockers: Plasma levels of fluphenazine hydrochloride and the beta-blocker may be increased. Dosage reduction of both drugs recommended. CNS Depressants, alcohol, analgesics:
On the other hand, The patient’s response to alcohol and other CNS depressants such as hypnotics, sedatives, or strong analgesics may be exaggerated while taking it combined use with narcotic analgesics may cause hypotension as well as CNS or respiratory depression.
Fluoxetine:
Meanwhile, Greater than tow fold increase in previously stable plasma levels of nortriptyline has occurred when fluoxetine medicine administered.
Methyphendrate:
Concurrent administration of tricyclic antidepressants with methylphenidate may cause paranoid. ideation.
Adverse Events:
A few adverse that have been reported with tricyclic antidepressants other than nortriptyline are include below because of the pharmacologic similar among the tricyclic antidepressant drug. Many of the events have reported with fluphenazine hydrochloride use at higher doses than those in this combination.
Blood and lymphatic system disorder:
Sublingual adenitis, agranulocytosis, aplastic anemia, leukopeni9a, eosinophilia, purpura, thrombocytopenia, and pancytopenia.
Immune system disorder:
Cross-sensitivity reaction with other tricyclic drugs, asthma, edema (general laryngeal, facial or of the tongue), anaphylactic reaction, (see skin subcutaneous tissue disorder).
Nervous system disorder: headache, confusion, drowsiness, dizziness, lethargy, delirium, numbness, tingling paresthesia of extremities, incoordination, ataxia, tremors, peripheral neuropathy, seizures, alteration in EEG patterns, alternation, is CDF proteins, tinnitus, cerebral edema, extrapyramidal symptoms, including pseudo parkinsonism, dystonia, dyskinesia, akathisia, oculogyric crisis, opisthodomos, and hyperreflexia (most often these extrapyramidal symptoms are reversible, however, they have persisted after long-term use in some patients); neuroleptic malignant syndrome, suicidal ideation, and suicidal behavior.
Renal and urinary disorder: Urinary retention, delayed micturition, polyuria bladder paralysis, urine frequency nocturia.
Pregnancy, puerperium, and perinatal condition: neonatal withdraw syndrome and extrapyramidal symptoms. Reproductive system and breast disorder: gynecomastia in the male, breast enlargement, galactorrhea in the female, testicular swelling, abnormal lactation, menstrual irregularities, false results on pregnancy tests, impotence, libido changes.
Overdose Symptoms & Treatment Guide
Overdose causes serious toxicity. The severity of the patient’s response to overdose generally conditioned by such factors as age, the amount ingested, amount absorbed, and the interval between ingestion and start of treatment. However, regardless of age, overdose should regarded as serious and potentially fatal and treated as a medical emergency.
The major signs and symptoms of toxic overdose with tricyclic antidepressants are primarily extensions of common adverse reactions. Symptoms of overdose may begin within several hours of ingestion.
- CNS symptoms
- Restlessness
- Drowsiness
- Sedation confusion
- Excitement
- Agitation
- Muscle rigidity
- Ataxia
- Hyperactive reflexes
- Choreographic movement
- Abnormal
- Eye movements.
Treatment: The drug should withdrawn and symptoms treated sportively in managing overdose, considering pharmacokinetics. On the other hand, Blood and urine levels of tricyclic antidepressants normally unreliable predictors of clinical management. As well as outcome and primarily useful for diagnosing overdose.
Most importantly, Intensive care procedures recommended, including establishing and maintaining a patent airway. As well as ensuring adequate oxygenation and ventilation and monitoring and support of the cardiovascular system.
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Motival Tablets Syrup Injection Capsules Price (Rs. 484 PKR) in India ( 380 INR) In USA ($ 7 USD)