Plavix Tablets Best Blood Thinner Medicine Uses Dosage Classification Side Effects Price

Plavix (Clopidogrel) Tablets Uses Dosage Side Effects Details

Plavix Tablets 75 mg: which contains Clopidogrel which is a familiar antiplatelet medicine used for the patients at high risk of heart disease and stroke. Similarly, when we talk about the classification of this drug it belongs to the Antiplatelet Agents drug class with Cardiovascular and Hematologic drug family. Therefore, Clopidogrel is a thienopyridine antiplatelet medicine which uses in thromboembolic disorders. So, as of of the best and rapid acting blood thinner used in any difficult situations where none of the drugs work effectively. But only expert pharmacist or doctors may compare the benefits and what are the side effects of plavix blood thinner? for a specific patient and than decide the exact dosage for the individual.

Other Useful Medicines: Hivate Cream Lotion Nasal Spray Uses Dosage Side Effects

There are many other tablets available in the market but the best two names are Plavix And Xarelto. Moreover, when we compare other blood thinner medicine like Plavix Vs Xarelto than we found that this is more affective than Xarelto as well as too much cheap for the patients. Here are all the details about all the other essential information about it.

Composition & Ingredients

• Each 75 MG Tablet contains Clopidogrel as (Hydrogen Sulfate) = 75 mg

Plavix Clopidogrel 75 MG Tablets Uses & Indications

Plavix Indications to adults for the prevention of atherothrombotic events in: But what is plavix tablets used for? is the big question and in which symptoms it can be used.

Used To Treat Recent MI, Recent Stroke, Or Established Peripheral Arterial Disease

Firstly, For patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease. Meanwhile, its use shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not). Consequently, the new MI (fatal or not) and other vascular death.

Acute Coronary Syndrome

• For patients with non-ST-segment elevation acute coronary syndrome (unstable angina/non-Q-wave myocardial infarction (MI). Including patients who are to be managed medically and those who are to be managed percutaneous coronary intervention (with or without stent) or CABG. It has shown to decrease the rate of a combined endpoint of cardiovascular death. MI or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia.
• For patients with ST-segment elevation acute myocardial infraction. Its use has shown to reduce the rate of death from any cause and the rate of a combined endpoint of death, re-infarction or stroke.

Atrial Fibrillation

In patients with atrial fibrillation (AF) at increased risk of vascular events who can take vitamin K antagonist (VKA) therapy. VKA has shown to be associated with a better clinical benefit than acetylsalicylic acid (ASA) alone or the combination of Plavix and ASA for the reduction of stroke. In patients with atrial fibrillation who have at least one risk factor for vascular events. And who cannot take VKA therapy (e.g. specific risk of bleeding, physician assessment that patient is unable to comply with INR (International normalized ratio monitoring or that VKA use is inappropriate). Generally indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events including strokes. Moreover in combination with ASA has shown to reduce the rate of the combined endpoint of stroke, myocardial infarction (MI). Non-CNS systemic embolism, or vascular death, largely through a reduction in stroke. In sudden attacks Plavix with Aspirin proves more effective in preventing another attack. But is increase the risk of bleeding.

Plavix Tablets Dosage And Administration

Plavix (Clopidogrel) Dosage in General for elderly or other ages patients.

Recent MI, Recent Stroke, Or Established Peripheral Arterial Disease

The Dosage forms should be given as a single daily dose of Clopidogrel 75 mg capsules.

Dosage for Acute Coronary Syndrome

For patients with non-ST-segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI), The capsules should initiated with a single 300-mg loading dose and then continued at Co Plavix 75/75 mg Tab use once daily. Acetylsalicylic acid (ASA) (75 mg up to 325 mg once daily) should initiated and continued in combination with this medicine. In CURE, most patients with Acute Coronary Syndrome also received heparin. For patients with ST-segment elevation acute myocardial infarction, the recommended dose is 75 mg once daily. Administered in combination with ASA, with or without thrombolytics. On the other hand, the dosage forms may be initiated with or without a loading dose (300mg used in CLARITY)

Dosage For Atrial Fibrillation

Moreover, the Dosage forms should given as a single daily dose of 75 mg. ASA (75-100 mg daily) should initiated and continued in combination with it.

Pharmacogenetics

CY2C19 poor metabolizer status is associated with diminished antiplatelet response to Plavix. A higher dose regimen (600 mg loading dose followed by 150 mg once daily) in poor metabolizers increases antiplatelet response. Consider the use of higher doses in patients who are poor CYP2C19 metabolizers. An appropriate dose regimen for this patient population has not established in clinical outcome trials.

Special Populations

Children: Safety and effectiveness in pediatric populations have not established. Elderly:     Plavix Dosage For Elderly there is no need of adjustment. Hepatic & Renal Impairment:   No dosage adjustment necessary.

Administration Guide For The Medicine

The medicine can administered with or without food. Take the tables with a glass of water and did not chew them.  

All Plavix 75mg Tablets Contraindications Details

Plavis Contraindications includes Hypersensitivity to the drug substance or any component of the product. On the other hand contraindications of the product also include Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

Warnings & Precautions Details

Plavix IV Use In Bleeding & Hematological Disorders

Due to the risk of bleeding and hematological undesirable effects, blood cell count determination and other appropriate testing should promptly considered. Then ever such suspected clinical symptoms arise during the course of treatment. Because of the increased risk of bleeding the concomitant administration of warfarin with it should undertaken with caution. As with other anti platelet agents, it should used with caution in patients who may be at risk of increased bleeding from trauma, surgery or other pathological conditions. If a patient is to undergo elective surgery and an antiplatelet effect is not desired clopidogrel should discontinued 5 to 7 days prior to surgery. Clopidogrel plavix iv prolongs bleeding time and should use with caution in patients who have lesions with a propensity to bleed. Drugs that might induce gastrointestinal lesions should use with caution in patients taking clopidogrel. Patients should told that it may take longer than usual to stop bleeding when they take it alone or in combination with ASA. And that they should report any unusual bleeding to their physician. Patients should inform physicians and dentists that they are taking clopidogrel before any surgery scheduled and before any new drug taken.

Use in Recent Ischemic Stroke

In patients with recent transient ischemic attack or stroke who are at high risk of recurrent ischemic events the combination of ASA and clopidogrel has shown to increase major bleeding. Therefore, such addition should undertaken with caution outside of clinical situations where the combination has proven to be beneficial.

Use In Thrombotic Thrombocytopenic Purpura (TTP)

Thrombotic, Thrombocytopenic Purpura TTP has been reported very rarely following the use of clopidogrel, sometimes after a short exposure. It characterized by thrombocytopenia and microangiopathic hemolytic anemia associated with either neurological findings, renal dysfunction or fever. TTP potentially fatal condition requiring prompt treatment including plasmapheresis.

Use In Acquired Haemophilia

Acquired hemophilia has been reported following use of clopidogrel. In cases of confirmed isolated activated Partial Thromboplastin Time (apt) prolongation with or without bleeding. Acquired hemophilia should considered. Patients with a confirmed diagnosis of acquired hemophilia should managed and treated by specialists. And clopidogrel should discontinued.

Use In Cytochrome P450 2C19 (CYP2C19)

Pharmacogenetics: In patients who are CYP2C19 poor metabolizers clopidogrel at recommended doses forms less of the active metabolite of clopidogrel. And has a smaller effect on platelet function. Poor metabolizers with acute coronary syndrome or undergoing percutaneous coronary intervention treated with clopidogrel at recommended doses may exhibit higher cardiovascular event rates than do patients with normal CYP2C19 function. Consider the use of higher clopidogrel dose in patient who are known CYP2C19 poor metabolizers.

For  Allergic Cross Reactivity

Patients should evaluated for history of hypersensitivity to another thienopyridine since allergic cross reactivity among thienopyridines has reported.

For Renal Impairment

Experience with clopidogrel limited in patients with severe renal impairment. Therefore clopidogrel should used with caution in this population.

Use In Hepatic Impairment

In the same vein, the experience is limited in patients with severe hepatic disease who may have bleeding diatheses. Clopidogrel should therefore used with caution in this population.

Brilinta Vs Plavix

However, Brilinta Vs Plavix categorized as the similar drugs. But brilinta cause more bleeding than plavix. On the other hand, there is a huge different when we talk about its Cost with plavix have a very low and affordable cost.

Excipients

Furthermore, the patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose galactose malabsorption should not take this medicine.

Medicine Use In Pregnancy

Plavix (Clopidogrel) 75 mg tab during Pregnancy there are no adequate and well controlled studies in pregnant women. So It should not use during pregnancy. Unless, in the opinion of physician there is a clear need of it. On the other hand, In Lactation it is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants. However, Decision should made whether to discontinue nursing or to discontinue the drug taking into account the importance of the drug to a nursing woman.

Plavix 75 MG Tablets Side Effects

Most importantly, these Side Effects for elderly and when use in long term have found after studies.

Clinical Studies Experience For Plavix Side Effects Elderly Long Term

Firstly, Clopidogrel has evaluated for safety in more than 44000 patients. Including over 12000 patients treated for 1 year or more. Meanwhile, tab 75mg per day was well tolerated without any significant side effects compared to Acetylsalicylic Acid (ASA 325) mg per day in CAPRIE. However, The overall tolerability of clopidogrel medicine in this study was similar to ASA regardless of age, gender and ethnicity. Similarly, the clinically relevant long term use of its adverse effects observed in CAPRIE, CURE, CLARITY, COMMIT and ACTIVE-A. On the other hand, Plavix And Diarrhea whenever discussed have a lot of connection as 75 is very affective and considered as the best medicine against diarrhea.

Central & Peripheral Nervous System Side Effects

Uncommon:   Headache, dizziness, paresthesia Rare:              Vertigo

Gastrointestinal System Side Effects

Common:        Dyspepsia, abdominal pain, diarrhoea Uncommon:     nausea, gastritis, flatulence, constipation, vomiting, gastric ulcer, duodenal ulcer

Platelet, Bleeding & Clotting Side Effects

Uncommon      Bleeding time increase, platelets decreased

 Skin & Appendages Side Effects

In CAPRIE, the most frequent events reported purpura/bruising and epistaxis. Uncommon:     Rash, Pruritus

White Cell & RES Side Effects

Uncommon:      Leucopenia, neutrophils decreased, eosinophilia

Post Marketing Experience

Firstly, the side effects have been ranked under heading of system organ class. Meanwhile, In some patients the side effects of fatigue or related type of condition also shown. However, Frequencies for the following adverse reactions are not known.

Blood And The Lymphatic System Disorders

Serious Cases of Bleeding

• Mainly Skin
• Musculo Skeletal

Retinal And Respiratory Tract Bleeding Epistaxis Hematuria and hemorrhage of operative wound. Cases of Bleeding with Fatal Outcome

• Agranulocytosis
• Aplastic Anemia
• Thrombotic Thrombocytopenic Purpura,
• Acquired Hemophilia A.

 Immune System Side Effects

• Anaphylactoid Reactions
• Serum Sickness

Cross reactive drug hypersensitivity among thienopyridines

Psychiatric Side Effects

• Confusion
• Hallucinations

Nervous System Disorders

• Taste Disturbances

Vascular Disorders

• Vasculitis
• Hypotension

Respiratory, Thoracic & Mediastinal Disorders

• Bronchospasm
• Interstitial Pneumonitis
• Eosinophilic Pneumonia

Gastrointestinal Disorders

• Colitis
• Pancreatitis
• Stomatitis

Hepato Biliary Disorders

• Hepatitis
• Acute Liver Failure

Skin And Subcutaneous Tissue Disorders

• Maculopapular or Erythematous Rash
• Urticaria
• Pruritus
• Angioedema
• Bullous Dermatitis
• Drug Induced Hypersensitivity Syndrome
• Drug rash with Eosinophilia
• Systemics Symptoms
• Eczema
• Lichen Planus

 Musculoskeletal, Connective Tissue & Bone Disorders

• Arthralgia,
• Arthritis,
• Myalgia

Renal & Urinary Disorders

• Glomerulopathy

 Overdose Symptoms & Treatment Guidelines

Signs & Symptoms

Firstly, the overdose following clopidogrel administration may lead to prolonged bleeding time and subsequent bleeding complications.

Treatment & Management

Most importantly, the appropriate therapy should considered if bleeding observed. Therefore, no antidote to the pharmacological activity of clopidogrel has found. However, If prompt correction of prolonged bleeding time required, platelet transfusion may reverse the effects of clopidogrel side effects.

Storage Guide For The Meds

Most importantly, Store Plavix (Clopidogrel) 75 mg tab between 15 to 30 C. On the other hand, you must keep all your medications out of the reach of your small kids. Consequently, also protect this medicine from moisture.

More Medicines: Dermazin Cream Ointment For Bed Sores Complications, Radiotherapy Burns And Infected Burn Wounds

Plavix (Clopidogrel) 75mg Tablets Price In Pakistan (418 PKR) & $ 5 USD In USA

 

Disclaimer

All the details of the medicine provided on this website Pharmacy Online Here are only for informational purposes and there is no intent to substitute for professional medical advice, diagnostic, and treatment purposes. Therefore, always get medical advice from any qualified healthcare provider doctor, or pharmacist for any questions about your medical conditions, symptoms, or disorder. So do not disregard the medical advice of your professional healthcare provider or delay it simply because of the information your read here on this website.  Note:– Always Use Any Type Of Medicines Only Under The Supervision Of A Professional Healthcare Provider, Doctor, Or Pharmacist.