Vibramycin Tablets 100 MG, 200 MG Syrup Uses Dosage Administration Side Effects Benefits Formula Ingredients Price Details

Vibramycin Tablets Syrup Uses Dosage Details

Vibramycin Tablets Syrup contains Doxycycline in it, which considered as a semi-synthetic, broad spectrum tetracycline antibiotic derived from methacycline. Meanwhile, Tetracyclines are derivatives of polycyclic naphthacenecarboxamide. They are bacteriostatic and effective against many gram-positive and gram-negative bacteria. It is the firs choice for prophylaxis of “travelers diarrhea”.

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Vibramycin Tablets Syrup Indications

Vibramycin Tablets Syrup use for the treatment of following Throat infections and other symptoms Like;

• Rocky Mountain spotted fever, typhus fever, and the typhus group;
• Q fever, rickettsialpox and tick fever caused by Rickettsiae;
• Respiratory infections caused by Mycoplasma pneumonia;
• Psittacosis caused by Chla mydia psittaci;
• Lymphogranuloma venereum, caused by Chla mydia trachomatis;
• Uncomplicated urethral, endocervical or rectal infections in adults caused by Chla mydia trachomatis;
• Trachoma caused by Chla mydia trachomatis although the infections agent is not always eliminated, as judged by immunofluorescence;
• Inclusion conjunctivitis caused by Chla mydia trachomatis may be treated with oral doxycycline alone or with a combination of topical agents;
• Acute epididymal-orchitis caused by Chla mydia trachomatis or Neisseria gonorrhoeae;
• Granuloma inguinale (donovanosis) caused by Calymmatobacterium granulomatous;
• Early (Stage 1 and 2 ) Lyme disease caused by Borrelia burgdorferr;
• Louse-bome relapsing fever caused by Borrelia recurrentis;
• Tick-borne relapsing fever caused by Borrelia recurrentis;
• Non-gonococcal urethritis (NGU) caused by Ureaplasma urealyticum (T-Mycoplasma).

On the other hand, Vibramycin Used For the treatment of infection caused by the following gram-negative microorganisms;

• Acinetobacter species;
• Bacteroides species;
• Fusobacterium species;
• Brucellosis caused by Brucella species (in conjunction with streptomycin);
• The plague caused by Yersinia pestis;
• Tularemia caused by Francisella tularensis;
• Bartonellosis caused by Bartonella bacilliformis;
• Campylobacter fetus.
• Because many strains of the following groups of microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended.

 

Meanwhile, Vibramycin Tablets Indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug;

• Shigella species;
• Uncomplicated gonorrhea caused by Neisseria gonorrhoeae;
• Respiratory infections caused by Haemophilus influenza.
• Respiratory and urinary infections caused by Klebsiella species;
• Escherichia coli;
• Enterobacter aerogenes;
• Moraxella catarrhalis.

On the other hand, Vibramycin also indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug;

• Streptococcus species: A certain percentage of strains of Streptococcus pyogenes and Streptococcus faecalis have been found to be resistant to tetracycline drugs.
• Tetracyclines should not be used for streptococcal infections unless the organism has been demonstrated to be sensitives.
• Anthrax due to Bacillus anthracis, including inhalational anthrax (post-exposure); to reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis.
• For upper respiratory infections due to group A beta-hemolytic streptococci, penicillin is the usual drug of choice, including prophylaxis of rheumatic fever. This includes;
• Upper respiratory tract infections caused by Streptococcus pneumoniae;
• Respiratory, skin and soft-tissue infections caused by Staphylococcus aureus. Tetracyclines are not the drug of choice in the treatment of staphylococcal infections.
• When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of:
• Actinomycosis caused by Actinomyces species;
• Infection caused by Clostridium species;
• Syphilis caused by Treponema pallidum and yaws caused by Treponema pertenue;
• Listeriosis caused by Listeria monocytogenes;
• Vincent’s infection (acute necrotizing ulcerative gingivitis) caused by Leptotrichia buccalis (formerly, Fusobacterium fusiform).

Adjunctive Treatment:

• In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides.
• In severe acne caused by Acne vulgaris, doxycycline may be useful adjunctive therapy.

Treatment of Prophylaxis:

The use for the prophylaxis and treatment of the following infections such as:

• Malaria caused by Plasmodium falciparum (in an area with chloroquine-resistant P. falciparum).
• Leptospirosis caused by genus Leptospira.
• Cholera caused by Vibrio cholera.

Prophylaxis

It mostly is indicated as prophylaxis in the following conditions Like;

• Scrub typhus caused by Rickettsia tsutsugamushi;
• Traveler’s diarrhea caused by enterotoxigenic Escherichia coli.

Vibramycin Tablets Dosage

However, It must be remembered that the usual dosage and frequency of administration of Vibramycin Tablets Syrups differs from that of most other tetracyclines. Meanwhile, exceeding the recommended dose may result in an increased incidence of side effects. Therefore, therapy should be continued at least 24 to 48 hours after symptoms and fever have subsided. Meanwhile, when used in streptococcal infections, therapy should continue for 10 days. However, it is important to prevent the development of rheumatic fever or glomerulonephritis. On the other hand, the usual dose in adults is Vibramycin 200 mg on the first day of treatment (administered as single dose or as 100mg tab every 12 hours). In addition, it followed by a maintenance dose of Vibramycin 100 mg/day (administered as a single dose or as 50 mg every 12 hours). However, In the management of more severe infections. On the other hand, 200 mg daily should be given throughout the treatment period.

For Children Above 8 Years Of Age:

Firstly, The recommended Vibramycin dosage schedule for children weighting 45 kg or less is 4.4 mg/kg of body weight followed by 2.2 mg/kg of body weight on subsequent days. Meanwhile, for more severe infections up to 4.4 mg/kg of body weight may be used. Most importantly, for children over 45 kg, the usual adult dose should used.

Tick, And Louse Borne Relapsing Fevers And Louse Borne Typhus

Consequently, It has successfully treated with a single oral dose of cap 100 or 200 mg according to severity. However, As an alternative to reduce the risk of persistence or relapse of tick-borne relapsing fever, doxycycline 100 mg every 12 hours for seven days recommended.

Early Lyme Disease:

Vibramycin 100 mg orally twice daily for 14-60 days according to clinical signs, symptoms, and response.

Uncomplicated Urethral, Endocervical Or Rectal Infections:

Furthermore, adults caused by Chla mydia trachomatis the tab by mouth twice daily for seven days.

Acute Epididymo Orchitis:

Caused by C-trachomatis or N.gonorrhoeae. Ceftriaxone 250 mg IM or another appropriate cephalosporin in a single dose plus doxycycline 100 mg by mouth twice daily for 10 days.

Non-Gonococcal Urethritis (NGU)

Caused by C.Trachomatis or Ureaplasma urealyticum, 100 mg by mouth twice daily for seven days.

Lymphogranuloma Venereum

Caused by C.Trachomatis, 100 mg orally twice daily for a minimum of 21 days.

Uncomplicated Gonococcal Infections Of The Cervix, Rectum Or Urethra

However, Where gonococci remain fully sensitive. Vibramycin 100 mg by mouth twice daily for seven days plus co-treatment with an appropriate cephalosporin or quinolone recommended. Meanwhile, Such as the following Cefixime 400 mg orally in a single dose or Ceftriaxone 125 mg intramuscularly (IM) in a single dose or Ciprofloxacin 500 mg orally in a single dose or Ofloxacin 400 mg orally in a single dose.

Uncomplicated Gonococcal Infection Of The Pharynx

Consequently, Where gonococci remain fully sensitive. 100 mg by mouth twice daily for seven days, plus co-treatment with an appropriate cephalosporin or quinolone recommended. Such as Cefftiraxone 125 mg IM in a single dose or Ciprofloxacin 500 mg orally in a single dose or Ofloxacin 400 mg orally in a single dose.

Primary And Secondary Syphillis

On the other hand, Non-pregnant penicillin-allergic patients who have primary or secondary syphilis can be treated with the regimen: 100 mg orally twice daily for two weeks as an alternative to penicillin therapy.

Latent And Tertiary Syphilis

Furthermore, Non-pregnant penicillin-allergic patients who have tertiary or secondary syphilis can be treated with the following regimen. Most importantly, 100 mg orally twice daily for two weeks as an alternative to penicillin for less than one year. Otherwise, doxycycline should be administered for four weeks.

All Contraindications

Most importantly, Vibramycin contraindicated in patients who have shown hypersensitivity to doxycycline any of its ingredients or to any of the tetracyclines.

Important Information For Patients Before Using This Product

Most importantly, all patients taking it should advise:

• To avoid excessive sunlight or artificial ultraviolet light while receiving doxycycline and to discontinue therapy if phototoxicity e.g. skin eruption etc occurs. Sunscreen or sunblock should be considered.
• Drink Fluids liberally along with doxycycline to reduce the risk of esophageal irritation and ulceration.
• That the absorption of tetracyclines reduced when taking bismuth subsalicylate.
• Use of doxycycline might increase the incidence of vaginal candidiasis.

Drug Interactions With Other Medicines

Firstly, there have been reports of prolonged prothrombin time in patients taking warfarin and doxycycline. Because the tetracyclines have been shown to depress plasma prothrombin activity. On the other hand, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Meanwhile, Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving doxycycline in conjunction with penicillin. On the other hand, Absorption of tetracycline is impaired by antacids containing aluminum, calcium, magnesium by antacids containing these cations, iron-containing preparations, and bismuth salts.

Laboratory Test Interactions:

False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.

Vibramycin Use In Fertility, Pregnancy And Lactation

Use in Pregnancy:

Firstly, Doxycycline has not been studied in pregnant patients. Therefore, it should not be used in pregnant women unless, in the judgment of the physician, the potential benefit outweighs the risk. However, results of animal studies indicate that tetracyclines cross the placenta, are found in fetal (often related to retardation of skeletal development). Evidence of embryotoxicity has also been noted in animals treated early in pregnancy.

Use In Lactation:

Meanwhile, As with other tetracyclines, doxycycline forms a stable calcium complex in any bone-forming tissue. However,  A decrease in the fibula growth rate has been observed in premature given oral tetracycline in doses of 25 mg/kg every six hours. Meanwhile, This reaction was shown to be reversible when the drug was discontinued. Consequently, Doxycycline should be avoided in nursing mothers, as tetracyclines including doxycycline are present in the milk of Lactating women who is taking a drug of this class.

Its Effects On Ability To Drive And Use Machines

Furthermore, The effect of doxycycline on the ability to drive or operate heavy machinery has not been studied. Meanwhile, there is no evidence to suggest that doxycycline may affect these abilities.

Vibramycin Tablets Syrups Side Effects

Most importantly, Following Vibramycin Side Effects observed in patients receiving tetracyclines, including doxycycline.

Blood And Lymphatic System Disorders

• Haemolytic
• Anaemia
• Neutropenia
• Thrombocytopenia
• Eosinophillia

Immune System Disorders

• Hypersensitivity (including anaphylactic shock
• Anaphylactic reaction
• Anaphylactoid reaction
• Angioedema
• Exacerbation of systemic lupus erythematosus
• Pericarditis
• Serum sickness
• Henoch-Schonlein purpura
• Hypotension
• Dyspnoea
• Tachycardia
• Peripheral edema and urticaria
• Drug reaction with Eosinophilia and Systemic
• Symptoms (DRESS)
• Jarisch-Herxheimer reaction

Endocrine Disorders

• Brown-black microscopic discoloration of thyroid glands

Metabolism and nutrition disorders

• Decreased appetite

Nervous system disorders

• Benign intracranial hypertension (pseudotumor cerebri)
• fontanelle bulging
• Headache

Ear and Labyrinth disorders

• Tinnitus

Vascular disorders

• Flushing

Gastrointestinal disorders

• Pancreatitis
• Pseudomembranous
• Colitis
• Clostridium difficile colitis
• Oesophageal ulcer
• Oesophagitis
• Enterocolitis
• On the other hand, Inflammatory lesions (with monilial overgrowth) in the anogenital region
• Dysphagia
• Abdominal pain
• Diarrhea
• Nausea / Vomiting
• Dyspepsia (heartburn / Gastritis)
• Glossitis
• It also use for tooth infection and discoloration

Hepatobiliary disorder

• Firstly, for Hepatotoxicity
• Hepatitis
• Lastly, for Hepatic Function abnormal

Skin and Subcutaneous tissue disorder

• Toxic epidermal necrolysis
• Stevens-Johnson Syndrome
• Erythema multiforme
• Dermatitis
• Exfoliative
• Photosensitivity reaction
• Skin hyperpigmentation
• Photoonycholysis
• Lastly, for Rash including maculopapular and erythematous rash

Musculoskeletal and connective tissue disorder

• Firstly for arthralgia
• Secondly for Myalgia

Renal and Urinary disorder

• Blood urea increased

 

Vibramycin Overdose Symptoms & Treatment

Moreover,  in case of medicine overdosage, immediately discontinue medication treat symptomatically and institute supportive measures. However, Dialysis does not alter serum half-life and thus would not be of benefit in treating cases of overdosage.

Storage Instructions

Most importantly, always note that keep all the medicines out of the reach of your children. On the other hand, store the Vibramycin tablets within 15 C to 30 C temperatures. Also, avoid exposure to heat or direct sunlight. Lastly, you must look for the medication expiry date printed on the packing. Meanwhile, if the medications are expired you must not use it because it may create a serious threat to your life.

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Vibramycin (Doxycycline) 100 MG, 200 MG Tablets Price (Rs. 55 PKR Per Strip)

 

Disclaimer

All the details of the medicine provided on this website Pharmacy Online Here are only for informational purposes and there is no intent to substitute for professional medical advice, diagnostic, and treatment purposes. Therefore, always get medical advice from any qualified healthcare provider doctor, or pharmacist for any questions about your medical conditions, symptoms, or disorder. So do not disregard the medical advice of your professional healthcare provider or delay it simply because of the information your read here on this website.  Note:– Always Use Any Type Of Medicines Only Under The Supervision Of A Professional Healthcare Provider, Doctor, Or Pharmacist.